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| 1 | Recent Progress on Two-dimensional Electrocatalysis显示文摘Due to their unique electronic and structural properties triggered by high atomic utilization and easy surface modification,two-dimensional(2D)materials have prodigious potential in electrocatalysis for energy conversion technology in recent years.In this review,we discuss the recent progress on two-dimensional nanomaterials for electrocatalysis.Five categories including metals,transition metal compounds,non-metal,metal-organic framework and other emerging 2D nanomaterials are successively introduced.Finally,the challenges and future development directions of 2D materials for electrocatalysis are also prospected.We hope this review may be helpful for guiding the design and application of 2D nanomaterials in energy conversion technologies. | FANG Wensheng HUANG Lei ZAMAN Shahid WANG Zhitong HAN Youjia XIA Bao Yu | 2020 | Chemical Research in Chinese Universities2020，36，4： | 7 |
| 2 | Sirt3-MnSOD axis represses nicotine-induced mitochondrial oxidative stress and mtDNA damage in osteoblasts显示文摘 | Yong Li Chen Yu Guangsi Shen Guangfei Li Junkang Shen Youjia Xu Jianping Gong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 6 |
| 3 | The histopathological features of the explanted lungs from an end-stage COVID-19 patient显示文摘Although the pathological findings of coronavirus disease 2019(COVID-19)associated with acute respiratory distress syndrome(ARDS)have been reported in previous studies,the data of histopatho-logical features of end-stage COVID-19 lungs are still lacking.We have previously reported the clini-cal features and managements of three COVID-19 patients with irreversible deterioration of pulmonary function who received lung transplantation(LT)after being supported by extracorporeal membrane oxygenation(ECMO)[1]. | Kai Li Youjia Yu Ding Li Changxing Luan Li Hu Jie Wang Jingjing Ding Yanfang Yu Hang Yang Jingyu Chen Feng Chen Chuan Su | 2020 | Forensic Sciences Research2020，5，4： | 1 |
| 4 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 5 | A geraniol synthase regulates plant defense via alternative splicing in tea plants显示文摘Geraniol is an important contributor to the pleasant floral scent of tea products and one of the most abundant aroma compounds in tea plants;however,its biosynthesis and physiological function in response to stress in tea plants remain unclear.The proteins encoded by the full-length terpene synthase(CsTPS1)and its alternative splicing isoform(CsTPS1-AS)could catalyze the formation of geraniol when GPP was used as a substrate in vitro,whereas the expression of CsTPS1-AS was only significantly induced by Colletotrichum gloeosporioides and Neopestalotiopsis sp.infection.Silencing of CsTPS1 and CsTPS1-AS resulted in a significant decrease of geraniol content in tea plants.The geraniol content and disease resistance of tea plants were compared when CsTPS1 and CsTPS1-AS were silenced.Down-regulation of the expression of CsTPS1-AS reduced the accumulation of geraniol,and the silenced tea plants exhibited greater susceptibility to pathogen infection than control plants.However,there was no significant difference observed in the geraniol content and pathogen resistance between CsTPS1-silenced plants and control plants in the tea plants infected with two pathogens.Further analysis showed that silencing of CsTPS1-AS led to a decrease in the expression of the defense-related genes PR1 and PR2 and SA pathway-related genes in tea plants,which increased the susceptibility of tea plants to pathogens infections.Both in vitro and in vivo results indicated that CsTPS1 is involved in the regulation of geraniol formation and plant defense via alternative splicing in tea plants.The results of this study provide new insights into geraniol biosynthesis and highlight the role of monoterpene synthases in modulating plant disease resistance via alternative splicing. | Hao Jiang Mengting Zhang Feng Yu Xuehui Li Jieyang Jin Youjia Zhou Qiang Wang Tingting Jing Xiaochun Wan Wilfried Schwab Chuankui Song | 2023 | Horticulture Research2023，10，10： | 0 |
| 6 | Recent advances in the study of sepsis-induced depression显示文摘Progress in medicine such as the use of anti-infective drugs and development of the advanced life support equipment has greatly improved the survival rate of patients with sepsis.However,the incidence of sepsis-relateddiseases is increasing.These include severe neurologic and psychologic disorders,cognitive decline,anxiety,depression,and post-traumatic stress disorder.Cerebral dysfunction occurs via multiple interacting mechanisms,with different causative pathogens having distinct effects.Because sepsis-related diseases place a substantial burden on patients and their families,it is important to elucidate the underlying pathophysiologic mechanisms todevelop effective treatments. | Yunyun Wang Youjia Zhu Mi Tian Yao Wang Xu Pei Junliang Jiang Yu He Ye Gong | 2023 | Journal of Intensive Medicine2023，3，3： | 0 |
| 7 | Exosome Biomarkers in Cardiovascular Diseases and their Prospective Forensic Application in the Identification of Sudden Cardiac Death显示文摘Sudden cardiac death(SCD)is a common cause of death due to the high prevalence and mortality of cardiovascular disease(CVD).Currently,the forensic identification of SCD relies on traditional histomorphological examination,lacking stable biomarkers with high specificity and sensitivity.Previous studies have shown that exosomes(Exos)are ideal vectors and the application of Exos provides novel insight as the diagnostic biomarkers and treatment of CVD,and is hot research filed in biomedicine.This review briefly describes the biology of Exos,including the biogenesis of Exos and the mechanisms of action.The research progresses on Exos multi‑omics,i.e.,genomics,proteomics and metabolomics,and their roles in the diagnosis of different types of CVD,especially coronary heart disease and cardiomyopathy,are summarized.In addition,the current difficulties of applications of Exos in forensic identification of SCD and the prospective forensic applications in the future are highlighted.The aim of this review is to summarize the current advances of Exos in CVD in a disease‑oriented manner,and to provide a reference for future forensic pathological identification of SCD,as well as the early diagnosis of SCD in clinic. | Ye Wang Jie Wang Li Hu Shuainan Huang Yue Cao Youjia Yu Feng Chen | 2022 | Journal of Forensic Science and Medicine2022，8，4： | 0 |
| 8 | Sudden Cardiac Death Due to Long QT Syndrome显示文摘Identification of sudden cardiac death(SCD)with a structurally normal heart remains an important challenge in forensic pathology.Long QT syndrome(LQTS)is known as an inherited or acquired channelopathy,which is characterized with prolonged QT interval,and is likely to cause SCD in young adults.In this circumstance,no specific pathological change in the heart can be found anatomically or histologically in the LQTS victims.Thus,postmortem LQTS diagnosis is mainly based on clinical manifestations and genetic testing.Here,we reported a 26‑year‑old woman who was found dead at home with a history of unexplained syncope.Her clinical records and an electrocardiograph(ECG)obtained 3 months before her death showed a QTc interval of 539 ms which implicates the diagnosis of LQTS.Although the autopsy and pathological examination findings lacked specificity,we noticed enhanced lipofuscin accumulation in cardiomyocytes,which might be related to LQTS.After excluding potential diseases and injuries,we made the postmortem diagnosis as LQTS according to ECG,clinical history,and forensic postmortem findings.In conclusion,we provided clinical and pathological features of an SCD case due to LQTS,which might enrich the understanding of forensic postmortem SCD diagnosis with nonstructural cardiac diseases. | Jiayi Wu Wei Tang Kai Zhang Kai Li Jianwen Wang Youjia Yu Feng Chen | 2022 | Journal of Forensic Science and Medicine2022，8，4： | 0 |
| 9 | Co_2O_3-doping Effect on the Formation of 3CaO 3Al_2O_3 CaSO_4显示文摘The Co2O3-doping effect on the formation of 3CaO-3Al2O3-CaSO4 from CaCO3-Al2O3-CaSO4-2H2O mixtures was investigated by means of SO2 emission behavior, chemical analysis, X-ray diffraction, differential thermal analysis and scanning electron microscopy. The experimental results show that Co2O3 addition increases the reactivity of the CaCO3-Al2O3-CaSO4-2H2O system significantly, by reducing SO2 emissions in combustion and f-CaO contents in the clinkers, promoting the nucleation and growth of 3CaO-3Al2O3-CaSO4, and intensifying the formation of 3CaO-3Al2O3-CaSO4. Moreover, Co2O3 addition lowers the formation temperature of 3CaO-3Al2O3-CaSO4 by 18 ℃, and similarly increases the thermal stability of it at a wider temperature range. | 郭惠玲 谢峻林 TAN Chang YU Youjia RAO Chengcheng | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，2： | 0 |
| 10 | Risk factors for postpartum posttraumatic stress disorder after emergency admission显示文摘BACKGROUND:Postpartum posttraumatic stress disorder(PTSD)can occur in women who give birth after emergency admission.The identification of risk factors for this condition is crucial for developing effective preventive measures.This retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency admission.METHODS:Medical records of women who gave birth after emergency admission were collected between March 2021 and April 2023.The patients’general conditions and perinatal clinical indicators were recorded.The puerperae were divided into PTSD group and control group based on symptom occurrence at six weeks postpartum.Multivariate logistic regression analysis was performed to identify risk factors.RESULTS:A total of 276 puerperae were included,with a PTSD incidence of 20.3% at six weeks postpartum.Multivariate logistic regression analysis identified emergency cesarean section(odds ratio[OR]=2.102;95%confidence interval[CI]:1.114-3.966,P=0.022),admission to the emergency department after midnight(12:00 AM)(OR=2.245;95%CI:1.170-4.305,P<0.001),and cervical dilation(OR=3.203;95%CI:1.670–6.141,P=0.039)as independent risk factors for postpartum PTSD.Analgesia pump use(OR=0.500;95%CI:0.259–0.966,P=0.015)was found to be a protective factor against postpartum PTSD.CONCLUSION:Emergency cesarean section,admission to the emergency department after midnight,and cervical dilation were identified as independent risk factors for postpartum PTSD,while analgesic pump use was a protective factor.These findings provide insights for developing more effective preventive measures for women who give birth after emergency admission. | Fengxia Du Jun Zha Yan Li Lichao Fang Shuyu Xia Youjia Yu | 2024 | World Journal of Emergency Medicine2024，15，2： | 0 |
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