|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation显示文摘The transcription factor CONSTANS(CO)integrates day-length information to induce the expression of florigen FLOWERING LOCUS T(FT)in Arabidopsis.We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter,and the N-terminal tandem B-box domains form a homomultimeric assembly.However,the mechanism and biological function of CO multimerization remained unclear.Here,we report that CO takes on a head-to-tail oligomeric configuration via its B-boxes to mediate FT activation in long days.The crystal structure of B-boxesCOreveals a closely connected tandem B-box fold forming a continuous head-to-tail assembly through unique CDHH zinc fingers.Mutating the key residues involved in CO oligomerization resulted in a non-functional CO,as evidenced by the inability to rescue co mutants.By contrast,a transgene encoding a human p53-derived tetrameric peptide in place of the B-boxesCOrescued co mutant,emphasizing the essential role of BboxesCO-mediated oligomerization.Furthermore,we found that the four TGTG-bearing cis-elements in FT proximal promoter are required for FT activation in long days.Our results suggest that CO forms a multimer to bind to the four TGTG motifs in the FT promoter to mediate FT activation. | Xiaolin Zeng Xinchen Lv Rui Liu Hang He Shiqi Liang Lixian Chen Fan Zhang Liu Chen Yuehui He Jiamu Du | 2022 | Journal of Integrative Plant Biology2022，64，3： | 2 |
| 2 | Fine-grained analysis of cellular smartphone usage characteristics based on massive network traffic显示文摘Increased adoption of smartphones leads to the explosive growth of mobile network traffic. Understanding the traffic characteristics of mobile network is important for Internet service providers(ISPs) to optimize network resources. In this paper, we conduct a detailed measurement study on the hyper text transfer protocol(HTTP) traffic characteristics of cellular network among different operating systems(OSs) as well as different device-types. Firstly, we propose a probability-based method to identify the installed OS of each smartphone. Then we analyze the traffic characteristics of these smartphones in terms of OS and device-type based on a dataset across 31 days(a billing cycle). Finally, we identify the installed apps of each smartphone and compare the usage of apps on the dimensions of OS and device-type. Our measurement study provides insights for network operators to strategize pricing and resource allocation for their cellular data networks. | Gui Xiaolin Liu Jun Li Chenyu Lv Qiujian Lei Zhenming | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，3： | 1 |
| 3 | The effects and mechanisms of high loading dose rosuvastatin therapy before percutaneous coronary intervention in patients with acute coronary syndrome显示文摘 | Jun Luo Jiang Li Xiangqian Shen Xinqun Hu Zhenfei Fang Xiaolin Lv Shenghua Zhou | 2012 | International Journal of Cardiology2012，，： | 1 |
| 4 | Serum amyloid A: A new potential serum marker correlated with the stageof breast cancer显示文摘 | Guojun Zhang Xudong Sun Hong Lv Xiaolin Yang Xixiong Kang | 2012 | Oncology Letters2012，，4： | 1 |
| 5 | Probabilistic Top-k Query:Model and Application on Web Traffic Analysis显示文摘Top-k ranking of websites according to traffic volume is important for Internet Service Providers(ISPs) to understand network status and optimize network resources. However, the ranking result always has a big deviation with actual rank for the existence of unknown web traffic, which cannot be identified accurately under current techniques. In this paper, we introduce a novel method to approximate the actual rank. This method associates unknown web traffic with websites according to statistical probabilities. Then, we construct a probabilistic top-k query model to rank websites. We conduct several experiments by using real HTTP traffic traces collected from a commercial ISP covering an entire city in northern China. Experimental results show that the proposed techniques can reduce the deviation existing between the ground truth and the ranking results vastly. In addition, we find that the websites providing video service have higher ratio of unknown IP as well as higher ratio of unknown traffic than the websites providing text web page service. Specifically, we find that the top-3 video websites have more than 90% of unknown web traffic. All these findings are helpful for ISPs understanding network status and deploying Content Distributed Network(CDN). | Xiaolin Gui Jun Liu Qiujian Lv Chao Dong Zhenming Lei | 2016 | China Communications2016，13，6： | 1 |
| 6 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 7 | c-Fos expression in rat brainstem following intake of sucrose or saccharin显示文摘To examine whether the activation of brainstem neurons during intake of a sweet tastant is due to orosensory signals or post-ingestive factors,we compared the distribution of c-Fos-like immunoreactivity(c-FLI)in the nucleus of the solitary tract(NST)and parabrachial nucleus(PBN)of brainstem following ingestion of 0.25 M sucrose or 0.005 M saccharin solutions.Immunopositive neurons were localized mainly in the middle zone of the PBN and four rostral-caudal subregions of the NST.Intake of sucrose increased the number of FLI neurons in almost every subnucleus of the PBN(F_((2,13))=7.610,P=0.023),in addition to the caudal NST at the level of the area postrema(F_((2,13))=10.777,P=0.003)and the NST intermediate zone(F_((2,13))=7.193,P=0.014).No significant increase in the number of c-Fos positive neurons was detected in response to saccharin ingestion,although there was a trend towards a modest increase in a few select NST and PBN nuclei.These results suggest that the PBN and NST may be involved in sweet taste perception and modulation of sweet tastant intake,but the significantly enhanced intensity of Fos expression induced by sucrose indicates that PBN/NST neuronal activity is driven by the integrated effects of sweet taste sensation and post-ingestive signals. | Ke Chen Jianqun Yan Jinrong Li Bo Lv Xiaolin Zhao | 2011 | Frontiers of Medicine2011，5，3： | 0 |
| 8 | How variable progenitor clones construct a largely invariant neocortex显示文摘The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable;yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex. | Zhongfu Shen Jiajun Yang Qiangqiang Zhang Kuiyu Wang Xiaohui Lv Xiaolin Hu Jian Ma Song-Hai Shi | 2024 | National Science Review2024，11，1： | 0 |
| 9 | Co-activation for enhanced K-ion storage in battery anodes显示文摘The relative natural abundance of potassium and potentially high energy density has established potassium-ion batteries as a promising technology for future large-scale global energy storage.However,the anodes'low capacity and high dis charge platform lead to low energy density,which impedes their rapid development.Herein,we present a possible co-activation mechanism between bismuth(Bi)and tin(Sn)that enhances K-ion storage in battery anodes.The co-activated Bi-Sn anode delivered a high capacity of634 mAh g^(-1),with a discharge plateau as low as 0.35 V,and operated continuously for 500 cycles at a current density of 50 mA g^(-1),with a high Coulombic efficiency of 99.2%.This possible co-activation strategy for high potassium storage may be extended to other Na/Zn/Ca/Mg/Al ion battery technologies,thus providing insights into how to improve their energy storage ability. | Yanhong Feng Yawei Lv Hongwei Fu Mihir Parekh Apparao MRao He Wang Xiaolin Tai Xianhui Yi Yue Lin Jiang Zhou Bingan Lu | 2023 | National Science Review2023，10，7： | 0 |
| 10 | National incidence of joint dislocation in China:a retrospective survey of 512,187 individuals显示文摘Background:Joint dislocations significantly impact public health.However,a comprehensive study on the incidence,distribution,and risk factors for joint dislocations in China is lacking.We conducted the China National Joint Dislocation Study,which is a part of the China National Fracture Study conducted to obtain the national incidence and risk factors for traumatic fractures,and to investigate the incidence and risk factors for joint dislocations.Methods:For this national retrospective epidemiological study,512,187 participants were recruited using stratified random sampling and probability-proportional-to-size method from January 19 to May 16,2015.Participants who sustained joint dislocations of the trunk,arms,or legs(skull,sternum,and ribs being excluded)in 2014 were personally interviewed to obtain data on age,educational background,ethnic origin,occupation,geographic region,and urbanization degree.The joint-dislocation incidence was calculated based on age,sex,body site,and demographic factors.The risk factors for different groups were examined using multiple logistic regression.Results:One hundred and nineteen participants sustained 121 joint dislocations in 2014.The population-weighted incidence rate of joint dislocations of the trunk,arms,or legs was 0.22(95%confidence interval[CI]:0.16,0.27)per 1000 population in 2014(men,0.27[0.20,0.34];women,0.16[0.10,0.23]).For all ages,previous dislocation history(male:OR 42.33,95%confidence interval[CI]:12.03-148.90;female:OR 54.43,95%CI:17.37-170.50)and alcohol consumption(male:OR 3.50,95%CI:1.49-8.22;female:OR 2.65,95%CI:1.08-6.50)were risk factors for joint dislocation.Sleeping less than 7 h/day was a risk factor for men.Compared with children,women aged≥15 years(female 15-64 years:OR 0.16,95%CI:0.04-0.61;female≥65 years:OR 0.06,95%CI:0.01-0.41)were less likely to sustain joint dislocations.Women with more than three children were at higher dislocation risk than women without children(OR 6.92,95%CI:1.18-40.78).Conclusions:The up-to-date data on joint dislocation incidence,distribution,and risk factors can be used as a reference for national healthcare,prevention,and management in China.Specific strategies for decreasing alcohol consumption and encouraging adequate sleeping hours should be developed to prevent or reduce dislocation incidents.Trial Registration:Chinese Clinical Trial Registry,ChiCTR-EPR-15005878. | Hongzhi Lv Wei Chen Zhiyong Hou Siming Jia Yanbin Zhu Bo Liu Xiao Chen Guang Yang Lei Liu Tao Zhang Haili Wang Bing Yin Song Liu Jialiang Guo Xiaolin Zhang Yichong Li Yingze Zhang | 2022 | Chinese Medical Journal2022，，14： | 0 |
| 11 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 12 | Interaction of AcMADS68 with transcription factors regulates anthocyanin biosynthesis in red-fleshed kiwifruit显示文摘In red-fleshed kiwifruit,anthocyanin pigmentation is a crucial commercial trait.The MYB-bHLH-WD40(MBW)complex and other transcription factors regulate its accumulation.Herein,a new SEP gene,AcMADS68,was identified as a regulatory candidate for anthocyanin biosynthesis in the kiwifruit by transcriptome data and bioinformatic analyses.AcMADS68 alone could not induce the accumulation of anthocyanin both in Actinidia arguta fruit and tobacco leaves.However,in combination with AcMYBF110,AcMYB123,and AcbHLH1,AcMADS68 co-overexpression increased anthocyanin biosynthesis,whereas its silencing reduced anthocyanin accumulation.The results of the dual-luciferase reporter,firefly luciferase complementation,yeast two-hybrid and co-immunoprecipitation assays showed that AcMADS68 could interact with both AcMYBF110 and AcMYB123 but not with AcbHLH1,thereby co-regulating anthocyanin biosynthesis by promoting the activation of the target genes,including AcANS,AcF3GT1,and AcGST1.Moreover,AcMADS68 also could activate the promoter of AcbHLH1 surported by dual-luciferase reporter and yeast one-hybrid assays,thereby further amplifying the regulation signals from the MBW complex,thus resulting in enhanced anthocyanin accumulation in the kiwifruit.These findings may facilitate better elucidation of various regulatory mechanisms underlying anthocyanin accumulation and contribute to the quality enhancement of red-fleshed kiwifruit. | Yanfei Liu Guowen Lv Yaqi Yang Kangxun Ma Xiaolin Ren Mingjun Li Zhande Liu | 2023 | Horticulture Research2023，10，2： | 0 |
| 13 | On the combination of data augmentation method and gated convolution model for building effective and robust intrusion detection显示文摘Deep learning(DL)has exhibited its exceptional performance in fields like intrusion detection.Various augmentation methods have been proposed to improve data quality and eventually to enhance the performance of DL models.However,the classic augmentation methods cannot be applied to those DL models which exploit the system-call sequences to detect intrusion.Previously,the seq2seq model has been explored to augment system-call sequences.Following this work,we propose a gated convolutional neural network(GCNN)model to thoroughly extract the potential information of augmented sequences.Also,in order to enhance themodel’s robustness,we adopt adversarial training to reduce the impact of adversarial examples on the model.Adversarial examples used in adversarial training are generated by the proposed adversarial sequence generation algorithm.The experimental results on different verified models show that GCNN model can better obtain the potential information of the augmented data and achieve the best performance.Furthermore,GCNN with adversarial training can enhance robustness significantly. | Yixiang Wang Shaohua lv Jiqiang Liu Xiaolin Chang Jinqiang Wang | 2018 | Cybersecurity2018，1，1： | 0 |
| 14 | On the combination of data augmentation method and gated convolution model for building effective and robust intrusion detection显示文摘Deep learning(DL)has exhibited its exceptional performance in fields like intrusion detection.Various augmentation methods have been proposed to improve data quality and eventually to enhance the performance of DL models.However,the classic augmentation methods cannot be applied to those DL models which exploit the system-call sequences to detect intrusion.Previously,the seq2seq model has been explored to augment system-call sequences.Following this work,we propose a gated convolutional neural network(GCNN)model to thoroughly extract the potential information of augmented sequences.Also,in order to enhance themodel’s robustness,we adopt adversarial training to reduce the impact of adversarial examples on the model.Adversarial examples used in adversarial training are generated by the proposed adversarial sequence generation algorithm.The experimental results on different verified models show that GCNN model can better obtain the potential information of the augmented data and achieve the best performance.Furthermore,GCNN with adversarial training can enhance robustness significantly. | Yixiang Wang Shaohua lv Jiqiang Liu Xiaolin Chang Jinqiang Wang | 2020 | Cybersecurity2020，3，1： | 0 |
| 15 | Immunogenicity and safety of a booster COVID-19 vaccination in patients with chronic liver disease:A multicenter study显示文摘Aim:Patients with chronic liver disease(CLD),especially cirrhosis,are at a high risk of severe illness or death from coronavirus disease-2019(COVID-19)and may have a suboptimal immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine.This study aimed to evaluate the safety and immunogenicity of the COVID-19 booster vaccination in patients with CLD.Methods:The study protocol was prospectively registered at ClinicalTrials.gov(No.NCT05204602)after approval by the Ethics Committee.Adult participants with CLD were enrolled in this multicenter prospective study.They completed two doses of the inactivated COVID-19 vaccine and received booster doses at least 6 months later.Adverse reactions were recorded within 14 days after the booster dose.Serum samples of the enrolled patients were collected before and after booster vaccination and tested for SARS-CoV-2 receptor-binding domain(RBD)immunoglobulin G and neutralizing anti-bodies.The chi-squared or Fisher's exact test was used to compare categorical data,and the Mann-Whitney U test was used to compare continuous variables.Two-sided p<0.05 were considered statistically significant.Results:In total,63 patients were enrolled from four hospitals in China,including 29 patients with cirrhosis.The median age of all patients was 55 years,and 61.9%(39/63)were male.The vaccines were well tolerated;most adverse reactions were mild and transient,and injection site pain(6.4%;4/63)and fatigue(3.2%,2/63)were the most frequent local and systemic adverse events.Following the booster vaccination,our results showed that in the whole cohort,the levels and positive rates of anti-RBD IgG and neutralizing antibodies were significantly higher than baseline levels(all p<0.05).Conclusions:The inactivated COVID-19 booster vaccine was safe and significantly increased antibody levels and positivity rates following standard vaccination regimens in patients with CLD,especially those with cirrhosis. | Jitao Wang Jingwen Ai Huiling Xiang Yanliang Zhang Zhiyun Hou Qiran Zhang Jiaojian Lv Shubo Chen Chuan Liu Qianqian Li Jing Liang Faren Xie Shujun Jiang Nina Zhang Aiguo Zhang Xiaolin Lan Xuying Zhang Jinlong Li Dengxiang Liu Wenchuan Wang Wei Rao Zhang Qun Qiuju Tian Xiaolong Qi Wenhong Zhang | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 16 | Application Technology of Tebuconazole WG against Sheath Blight 75% Trifloxystrobin · Rice Blast and Rice显示文摘 | Zhang Shun Zeng Delin Yang Shouli Lei Dehua Lv Liang Chang Xiangqian Yang Xiaolin Yuan Bin | 2013 | Plant Diseases and Pests2013，4，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员