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| 1 | Variation of temporal and spatial patterns of NO_2 in Beijing using OMI and mobile DOAS显示文摘Control policies such as 'odd-and-even license plate rule' were implemented by the Chinese government to restrict traffic and suspend factory production in Beijing and neighboring cities during the Asia-Pacific Economic Cooperation summit. We use ozone monitoring instrument(OMI), mobile differential optical absorption spectroscopy(DOAS), and multi-axis differential optical absorption spectroscopy(MAX-DOAS) to measure the variation of the spatial and temporal patterns of NO2 column densities from October 24, 2014 to November 22, 2014. It is found that the NO2 column densities during the episode of control policies are significantly lower than those during other periods, and the emission flux of NO2 calculated by mobile DOAS is also lower than the results from other periods. Some daily low NO2 column densities occur with the northwest wind direction. We then compare the relationship between OMI and mobile DOAS NO2 column density observations, and the results of mobile DOAS are approximately 2.7 times larger than the OMI values. The largest discrepancy occurs in the northern part of Beijing city. In other parts, the two instruments have a better correlation coefficient(R2) of 0.61. The low NO2 column densities that occur during the episode of control policies are affected by the control policies as well as meteorological conditions. | Ang Li Jie Zhang Pinhua Xie Zhaokun Hu Jin Xu Fusheng Mou Fengcheng Wu Jianguo Liu Wenqing Liu | 2015 | Science China Chemistry2015，58，9： | 5 |
| 2 | Distribution and anti-HBV effects of antisense oligodeoxynu-cleotides conjugated to galactosylated poly-L-lysine显示文摘AIM: To describe distribution of the phosphorothioated antisense oligodeoxynucleotides (PS-asODNs) conjugated to galactosylated poly-L-lysine (Gal-PLL) in mice, and to observe their effects on expression of HBV gene in the 2.2.15 cells and transgenic mice.METHODS: According to the result of direct sequencing of PCR amplified products, a 16 mer phosphorothioate analogue of the antisense oligodeoxynucleotides (PS-asODNs) directed against the HBV U5-like region was conjugated to the hepatotropic Gal-PLL molecules. Its distribution was demonstrated using asODNs labeled with ^32p at the 5' terminus with a T4-polynucleotide Kinase. Its inhibition effect on HBV expression was observed in the transfected 2.2.15 cells and transgenic mice.RESULTS: The Gal-PLL and asODNs could form stable complex at a molar ratio of 2:1. As shown in the HBV-transfected 2.2.15 cells, the inhibition effects of asODNs alone and asODNs conjugated to Gal-PLL, at 10μmol/L for both, on HBsAg and HBeAg production were different,the former being 70 % and 58 %, respectively, and the latter being 96 % and 82 %, respectively. A more pronounced reduction was also observed in viral DNA load in the culture supernatant for the test with Gal-PLL-asODNs. Among many mouse organs, livers retained more asODNs molecules after administration. The preferential concentration in liver was found to be 52.14 % for Gal-PLL-asODNs, as high as 2.38-fold of that for asODNs (21.9 %). Both elements decreased gradually in liver, with 2.9 % of the former, 5.99 % of the latter retained 24 hours after the administration. The injection interval, therefore, was recommended to be 24 hours. In the transgenic mice, serum HBsAg decreased significantly (P<0.01) at the 12th day after administrating Gal-PLL- asODNs, the serum HBV DNA turned negative in 4 of the 6 mice.CONCLUSION: Antisense oligodeoxynucleotides conjugated to Gal-PLL can be concentrated in liver and intaked by hepatocytic cells. This may result in specific inhibition of expression and replication of HBV in vitro and in vivo. | Su-JunZheng SenZhong Jian-JunZhang FengCheng HongRen Cun-LiangDeng | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 3 | A Novel Unsupervised Change Detection Method with Structure Consistency and GFLICM Based on UAV Images显示文摘With the rapid development of Unmanned Aerial Vehicle(UAV)technology,change detection methods based on UAV images have been extensively studied.However,the imaging of UAV sensors is susceptible to environmental interference,which leads to great differences of same object between UAV images.Overcoming the discrepancy difference between UAV images is crucial to improving the accuracy of change detection.To address this issue,a novel unsupervised change detection method based on structural consistency and the Generalized Fuzzy Local Information C-means Clustering Model(GFLICM)was proposed in this study.Within this method,the establishment of a graph-based structural consistency measure allowed for the detection of change information by comparing structure similarity between UAV images.The local variation coefficient was introduced and a new fuzzy factor was reconstructed,after which the GFLICM algorithm was used to analyze difference images.Finally,change detection results were analyzed qualitatively and quantitatively.To measure the feasibility and robustness of the proposed method,experiments were conducted using two data sets from the cities of Yangzhou and Nanjing.The experimental results show that the proposed method can improve the overall accuracy of change detection and reduce the false alarm rate when compared with other state-of-the-art change detection methods. | Wensong LIU Xinyuan JI Jie LIU Fengcheng GUO Zongqiao YU | 2022 | Journal of Geodesy and Geoinformation Science2022，5，1： | 2 |
| 4 | The protective mechanism of Yisheng Injection against hepatic ischemia reperfusion injury in mice显示文摘Hepatic ischemia/reperfusion injury may cause acuteinflammatory, significant organ damage or dysfunction, andremains an important problem for liver transplantation.Our previous in vivo and in vitro studies demonstrated thatYisheng injection (YS), a traditional Chinese medicine, hadprotective effect on ischemia/reperfusion injury. In thisstudy, we examined whether YS had protective effect forhepatic ischemia/reperfusion injury and explored itsprotective mechanism. | FengCheng You-PingLi Jing-QiuCheng LiFeng Sheng-FuLi | 2004 | World Journal of Gastroenterology2004，10，8： | 2 |
| 5 | Recommendation system for localized products in ven- ding machines显示文摘 | LIN Fengcheng YU Hsinwen HSU Chihhao | 2011 | Expert Systems with Applications2011，38，8： | 1 |
| 6 | Evaluation of disintegrating time of rapidly disintegrating tablets by a paddle method 显示文摘 | Li Que Wei Wu Xiao Fengcheng | 2006 | Pharm Dev Technol2006，11，3： | 1 |
| 7 | Production of biscuits by substitution with different ratios of yellow pea flour显示文摘To promote the commercialization of yellow pea flour(YPF)due to its nutritional benefits.Four biscuits with different YPF ratio(10%–50%)were conducted to explore the optimal addition percentage.The effects of YPF on the rheological and baking performance of biscuits were performed.The results showed that the substitution ratio of YPF and milling methods had a critical impact on the rheological properties of dough.The dough stability decreased graduallywhile a softening degree increased with YPF ratio increased.In a term of biscuits,the dimensions of length(L),width(W),thickness(T)and color(L*)of biscuits reduced as YPF addition ratio increased,while colors(a*and b*)and hardness apparently increased.In addition,milling methods had a great influence on the texture and sensory evaluation of four biscuits.The dimensions and color parameters of biscuits from fine flours were larger than that from coarse flours,whereas hardness from fine flours was relatively softer,indicating flour with fine particle size could accelerate the extension and expansion of dough network,and improve Maillard reaction during baking.The highest sensory score for short and tough biscuits was obtained given at YPF ratio of 30%without compromising the qualities of biscuits. | Jikai Zhao Xin Liu Xiang Bai Fengcheng Wang | 2019 | Grain & Oil Science and Technology2019，2，4： | 1 |
| 8 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 9 | Arabinose substitution degree in xylan positively affects lignocellulose enzymatic digestibility after various NaOH/H 2 SO 4 pretreatments in Miscanthus显示文摘 | Fengcheng Li Shuangfeng Ren Wei Zhang Zhengdan Xu Guosheng Xie Yan Chen Yuanyuan Tu Qing Li Shiguang Zhou Yu Li Fen Tu Lin Liu Yanting Wang Jianxiong Jiang Jingping Qin Shizhong Li Qiwei Li Hai-Chun Jing Fasong Zhou Neal Gutterson Liangcai Peng | 2012 | Bioresource Technology2012，，： | 1 |
| 10 | Three lignocellulose features that distinctively affect biomass enzymatic digestibility under NaOH and H 2 SO 4 pretreatments in Miscanthus显示文摘 | Wei Zhang Zili Yi Jiangfeng Huang Fengcheng Li Bo Hao Ming Li Shufen Hong Yezi Lv Wei Sun Arthur Ragauskas Fan Hu Junhua Peng Liangcai Peng | 2012 | Bioresource Technology2012，，： | 1 |
| 11 | DON reduction of wheat grain without compromising the lab-scale milling properties of flour显示文摘Wheat branwas investigated to be themost commonly contaminated raw material by mycotoxins.However,there are no economical and practical pretreatment methods for industrial on-line application until now.The effect of light debranning on deoxynivalenol(DON)removal,polyphenol oxidase(PPO)activity and flour quality from lab-scale milling were performed.For on-line production,the DON concentration in wheat decreased 15.89%at debranning ratio of 1.2%.For lab experiment,the maximum DON removal for wheat and flour was 23.35%and 21.95%,respectively.However,the PPO activity,browning of dough sheet and flour qualities in lab scale exhibited no significant variation.Light debranning(1.2%)prior to milling could be efficiently applied to on-line wheat production. | Jikai Zhao Xin Liu Fengcheng Wang | 2019 | Grain & Oil Science and Technology2019，2，3： | 1 |
| 12 | Evaluation of disintegra ting time of rapidly disintegrating tablets by a paddle method 显示文摘 | Li Que Wei Wu Xiao Fengcheng | 2006 | Pharm Dcv Techrwl2006，11，3： | 1 |
| 13 | Mathematical modeling of multi-plant order allocation problem and solving by genetic algorithm with matrix rep- resentation 显示文摘 | Yang Fengcheng Chen Kuentai Wang Mingtzong | 2010 | The International Journal of Advanced Manufacturing Technology2010，51，912： | 1 |
| 14 | Si- multaneous Measurement of Velocity and Temperature Fluctuations in Thermal Boundary Layer in a Drag- Reducing Surfactant Solution Flow 显示文摘 | LI Fengcheng WANG Dezhong Kawaguchi Y | 2004 | Experiments in Fluids2004，36，13： | 1 |
| 15 | Numerical And Ex- perimental Investigation of T-rbulent Characteristics in a Drag-Reducing Flow With Surfactant Additives 显示文摘 | YU Bo LI Fengcheng Kawaguchi Y | 2004 | In- ternational Journal of Heat and Fluid Flow2004，25，96： | 1 |
| 16 | Preparation and evaluation of molecularly imprinted solid-phase micro-extraction fibers for selective extraction of phthalates in an aqueous sample显示文摘 | Juan He Ruihe Lv Haijun Zhan Huizhi Wang Jie Cheng Kui Lu Fengcheng Wang | 2010 | Analytica Chimica Acta2010，，1： | 1 |
| 17 | Mathematical modeling of multi-plant order allocation problem and solving by genetic algorithm with matrix representation 显示文摘 | YANG FENGCHENG CHEN KUENTAI WANG MINGTZONG | 2010 | In- ternational Journal of Advanced Manufacturing Technology2010，51，： | 1 |
| 18 | Docosahexaenoic acid is superior to eicosapentaenoic acid as the essential fatty acid for growth of grouper, Epinephelus malabaricus 显示文摘 | Wu FengCheng Ting YunYuan Chen HoungYung | 2002 | Journal of Nutrition2002，132，1： | 1 |
| 19 | Temperature field reconstruction method for aero engine exhaust using the colored background oriented Schlieren technology显示文摘The detection of the jet temperature field in an aircraft engine tail is an effective way to reflect the running state of an engine. To solve the complicated detection process of current laser diagnostic methods, the colored background oriented Schlieren(CBOS) method was proposed to obtain a tail jet temperature field. First, the background Schlieren image with three-color points was collected for the exhaust gas temperature(EGT) field of the engine. Then the refractive index field of the engine exhaust was obtained according to the proposed CBOS method. Finally, the three-dimensional EGT field was reconstructed through the refractive index field. The simulation and the experimental results show the feasibility and effectiveness of the proposed method. | SONG Fengcheng WU Jun ZHU Yuheng XU Haitao LI Yanling YU Zhijing | 2022 | Optoelectronics Letters2022，18，4： | 1 |
| 20 | Mathematical modeling of multi-plant order allocation problem and solving by genetic algorithm with matrix representation显示文摘 | Yang Fengcheng Chen Kuentai Wang Mingtzong | | 0，，09： | 1 |
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