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| 1 | 拟南芥CBF4基因位点的单核苷酸多态性(SNP)变化与抗旱表型的相应性显示文摘以生长于不同生态气候条件下的17个拟南芥(Arabidopsisthaliana )核心生态型为材料,分析了它们的相对抗旱性和抗旱转录因子CBF4 基因的单核苷酸多态性(SNP)。结果表明,不同的拟南芥生态型具有差异明显的抗旱性。与拟南芥Columbia生态型相比,25av、203av和244av生态型的CBF4基因位点具有高密度的SNP和插入/缺失(Indel),多态性的频率为每35.8 bp 1个SNP,每143 bp 1个Indel。Tajima'S D统计学检验结果显示各区域都不显著,说明该区域核苷酸变化符合中性突变假说,较高的核苷酸多样性是净化选择的结果。基因非编码区的多态性是编码区的4倍,表明编码区承受着更大的选择压力。在编码区,SNP的频率为每96.4 bp 1个SNP,其中1034位(以GenBank No.AB015478序列第19 696位的核苷酸为1)碱基变化:G圮T,引起第205位氨基酸变化:gly圮val。而203av形成的haplotype 6具有4个特异的SNP变化,其中5'端非编码区3个:27位的A圮G,129位的A圮C,171位的G圮A;3'端非编码区1个:1106位的A圮C。抗旱性鉴定结果表明203av拟南芥是抗旱性最强的一个生态型, 研究认为haplotype 6与它较强的抗旱性表型相应。 | 郝岗平 吴忠义 陈茂盛 曹鸣庆 Dominique Brunnel Georges Pelletier 黄丛林 杨清 | 2004 | 农业生物技术学报2004，12，2： | 16 |
| 2 | 锆基非晶合金的动态弛豫机制和高温流变行为显示文摘非晶合金的动态弛豫机制对于理解其塑性变形,玻璃转变行为,扩散机制以及晶化行为都至关重要.非晶合金的力学性能与动态弛豫机制的本征关联是该领域当前重要科学问题之一.本文借助于动态力学分析(DMA),探索了Zr50Cu40Al10块体非晶合金从室温到过冷液相区宽温度范围内的动态力学行为.通过单轴拉伸实验,研究了玻璃转变温度附近的高温流变行为.基于准点缺陷理论(quasi-point defects theory),对两种力学行为的适用性以及宏观力学行为变化过程中微观结构的演化规律进行描述.研究结果表明,准点缺陷理论可以很好地描述非晶合金损耗模量α弛豫的主曲线.基于非晶合金的内耗行为,玻璃转变温度以下原子运动的激活能Uβ为0.63 eV.与准点缺陷浓度对应的关联因子χ在玻璃转变温度以下约为0.38,而在玻璃转变温度以上则线性增大.Zr50Cu40Al10块体非晶合金在玻璃转变温度附近,随温度和应变速率的不同而在拉伸实验中显示出均匀的或不均匀的流变行为.非晶合金的高温流变行为不仅可以通过扩展指数函数和自由体积理论来描述,还可以通过基于微剪切畴(shear micro-domains,SMDs)的准点缺陷理论来描述. | 郝奇 乔吉超 Jean-Marc Pelletier | 2020 | 力学学报2020，52，2： | 10 |
| 3 | Evolution and predictive factors of thyroid disorder due to interferon alpha in the treatment of hepatitis C显示文摘AIM:To study predictive factors of thyroid dysfunction associated with interferon-alpha(IFNα) therapy in chronic hepatitis C(CHC) and to describe its long-term evolution in a large population without previous thyroid dysfunction.METHODS:We performed a follow-up of thyroid function and detection of thyroid antibodies in 301 patients treated for CHC with IFNα from 1999 to 2004.RESULTS:Thyroid disorder developed in 30/301(10%) patients with a mean delay of 6 ± 3.75 mo:13 patients had hyperthyroidism,11 had hypothyroidism,and 6 had biphasic evolution.During a mean follow-up of 41.59 ± 15.39 mo,9 patients with hyperthyroidism,3 with hypothyroidism,and 4 with biphasic evolution normalized thyroid function in 7.88 ± 5.46 mo.Recovery rate of dysthyroidism was not modified by treatment discontinuation,but was better for patients with negative thyroid antibodies before antiviral treatment(P = 0.02).Women had signif icantly more dysthyroidism(P = 0.05).Positive thyroid peroxidase and thyroglobulin antibodies were more frequent before antiviral treatment in patients who developed dysthyroidism(P < 0.0003 and P = 0.0003,respectively).In a multivariate model,low fibrosis was found to be a predictive factor of dysthyroidism(P = 0.039).CONCLUSION:In this monocentric population of CHC,dysthyroidism,especially hyperthyroidism,developed in 10% of patients.Low fibrosis was found to be a predictive factor of dysthyroidism.Thyroid disorder recovered in 16/30 patients(53%) and recovery was better in the non-autoimmune form. | Moana Gelu-Simeon Aurore Burlaud Jacques Young Gilles Pelletier Catherine Buffet | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 4 | ATHK1基因调节拟南芥渗透胁迫信号转导过程显示文摘以拟南芥ATHK1基因T-DNA插入所产生的缺失突变体和野生型WS(Wassilewskija)生态型为材料,分析了它们在生理和基因表达方面的差异。结果表明突变体的离体叶片失水率明显大于野生型;在30%PEG-6000胁迫后,野生型和ATHK1突变体的细胞膜离子外渗率比胁迫前分别增加了50%和80%。PEG胁迫48 h时突变体的萎蔫程度明显大于野生型WS。以上结果说明ATHK1突变体的抗渗透胁迫能力低于野生型,即ATHK1基因参与了拟南芥适应逆境的调节反应。利用DDRT-PCR技术研究二者在PEG胁迫36 h后的基因表达差异,分离到9个在野生型中被PEG诱导表达而在突变体中未被诱导的参与逆境应答的基因片段,其中包括MAPKKK18和丝氨酸/苏氨酸蛋白激酶基因,即ATHK1基因失活引起下游基因响应渗透胁迫的能力减弱,进一步说明ATHK1基因参与拟南芥适应逆境的调节反应,并且ATHK1可能在逆境信号转导组分MAPK的上游起作用,很可能是植物体中的渗透感受器。 | 郝岗平 吴忠义 陈茂盛 曹鸣庆 Georges Pelletier 黄丛林 杨清 | 2004 | 植物生理与分子生物学学报2004，30，5： | 8 |
| 5 | 拟南芥抗旱转录因子CBF4基因区域的核苷酸多样性及其分子进化分析显示文摘以生长于不同气候条件下的 17个拟南芥核心生态型为材料 ,分析了它们的抗旱转录因子CBF4基因区域的序列多态性。结果表明 :拟南芥CBF4基因区域具有高密度的单核苷酸多态性 (SNP)和插入缺失 (Indel) ,多态性频率为每 35 8bp一个SNP ,每 14 3bp一个Indel,基因非编码区的多态性是编码区的 4倍 ;在编码区 ,SNP的频率为每 96 4bp一个SNP ,其中发现 2 5av、2 0 3av和 2 4 4av 3个生态型CBF4基因区域 10 34位 (以GenBank登录号AB0 15 4 78序列第 196 96位的核苷酸为 1)碱基变化 :G T ,引起第 2 0 5位氨基酸变化 :gly val。核苷酸多样性统计分析显示 ,该基因内部大范围内存在连锁不平衡 (linkagedisequilibrium ,LD) ,5′端非编码区有一个重组。与拟南芥等的研究结果类似 ,选择压力对不同的区域作用不同。 3′端非编码区核苷酸多样性程度最高 ,是平衡性选择的结果 ,编码区核苷酸变化符合中性突变假说 ,而 | 郝岗平 吴忠义 曹鸣庆 Georges Pelletier Dominique Brunel 黄丛林 杨清 | 2004 | Acta Genetica Sinica2004，31，12： | 7 |
| 6 | Main α relaxation and slow β relaxation processes in a La30Ce30Al15Co25 metallic glass显示文摘Dynamic relaxation processes are fundamental to understand the mechanical and physical properties of metallic glasses. In the current work, mechanical relaxations in a La30Ce30Al15Co25 bulk metallic glass were probed by dynamic mechanical analysis. In contrast to many metallic glasses, La30Ce30Al15Co25 metallic glass shows a pronounced slow β relaxation peak. Physical aging below the glass transition temperature Tgleads to an increase of the apparent activation energy and a decrease of the slow β relaxation magnitude. The correlation between the slow β relaxation and the main α relaxation is discussed. | J.C. Qiao Y.H. Chen R. Casalini J.M. Pelletier Y. Yao | 2019 | Journal of Materials Science & Technology2019，35，6： | 4 |
| 7 | In vivo selective inhibition of mitogen‐activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes显示文摘 | Jean‐PierrePelletier Julio C.Fernandes JulieBrunet FlorinaMoldovan DenisSchrier CraigFlory JohanneMartel‐Pelletier | 2003 | Arthritis & Rheumatism2003，，6： | 2 |
| 8 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 9 | Increasing United States Hospital Admissions for Acute Pancreatitis, 1988–2003显示文摘 | Peter J. Fagenholz Carlos Fernández-Del Castillo N. Stuart Harris Andrea J. Pelletier Carlos A. Camargo | 2007 | Annals of Epidemiology2007，，7： | 2 |
| 10 | Influence of viscoelasticity on the tribological behaviour of carbon black filled nitrile rubber (NBR) for lip seal application显示文摘 | J.-M. Degrange M. Thomine Ph. Kapsa J.M. Pelletier L. Chazeau G. Vigier G. Dudragne L. Guerbé | 2005 | Wear2005，，1： | 2 |
| 11 | Risk Factors of Pancreatic Fistula and Delayed Gastric Emptying after Pancreaticoduodenectomy with Pancreaticogastrostomy显示文摘 | Emilie Lermite Patrick Pessaux Olivier Brehant Carlos Teyssedou Isabelle Pelletier Sandrine Etienne Jean-Pierre Arnaud | 2007 | Journal of the American College of Surgeons2007，，4： | 2 |
| 12 | Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product显示文摘 | NAKAGAMA H HEINRICH G PELLETIER J | 1995 | Mol Cell Biol1995，15，3： | 1 |
| 13 | Effect of porcine growth hormone-releasing factor (1-29) NH2 and thyrotropin-factor on pig growth performance显示文摘 | Dubreuil P Couture Y Pelletier G | 1990 | Can J Anim Sci1990，70，： | 1 |
| 14 | A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI显示文摘 | Pelletier JP Raynauld JP Abram F | 2008 | Osteoarthritis Cartilage2008，16，3： | 1 |
| 15 | Glu- cocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal hu-man chondrocytes显示文摘 | DiBattista J A Martel Pelletier J Wosu L O | 1991 | J Clin Endocrinol Metab1991，72，2： | 1 |
| 16 | Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases 显示文摘 | Chen SC Pelletier DB Ao P | 1995 | Cell Growth Differ1995，6，6： | 1 |
| 17 | Generation of a high-energy electron tail by strong Langmuir turbulence in a plasma 显示文摘 | PELLETIER G | 1982 | Phys Rev Lett1982，49，11： | 1 |
| 18 | A tandem three-phase reaction for preparing secondary amines with minimal side products显示文摘 | Pelletier J C Khan A Tang Z L | 2002 | Organic Letters2002，4，26： | 1 |
| 19 | 16SrDNA Amplification for Phylogenetic Study显示文摘 | WEISBNRG W G BAMS S M PELLETIER D A | 1991 | J Bacteriol1991，173，： | 1 |
| 20 | Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology显示文摘 | Pelletier JP Martel-Pelletier J | 2003 | Ann Rheum Dis2003，62，2： | 1 |
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