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| 1 | 北祁连早古生代花岗质岩浆作用及构造演化显示文摘北祁连山中段花岗岩锆石SHRIMP定年结果表明,柯柯里岩体的斜长花岗岩和石英闪长岩的年龄分别为512Ma和501 Ma,野马咀和金佛寺花岗岩的年龄分别为508Ma和424Ma。结合区内其它花岗岩体的定年资料,根据花岗岩的岩石地球化学特征及岩体产出的构造位置、区域地质资料等,我们认为,早古生代北祁连洋板块向南俯冲,至少引发了两期花岗质岩浆作用,第一次岩浆作用形成柯柯里斜长花岗岩(512Ma)、野马咀花岗岩(508Ma)和柯柯里石英闪长岩(501 Ma),第二次花岗质岩浆作用形成牛心山花岗岩(477Ma)。由于往南俯冲的板块受到柴达木板块向北俯冲的影响,俯冲受阻,继而俯冲极性发生变化,转向北俯冲,形成了民乐窑沟(463Ma)等花岗岩侵入体。大约440Ma之后,洋盆闭合,柴达木陆块和阿拉善陆块对接碰撞,形成北祁连造山带。由于造山带根部岩石圈发生折沉作用,造山带上不同的块体伸展、滑塌,形成一系列碰撞后花岗岩如金佛寺花岗岩(424Ma)及牛心山岩体的石英闪长岩(435Ma)等。 | 吴才来 徐学义 高前明 李向民 雷敏 郜源红 Ronald B FROST Joseph L WOODEN | 2010 | 岩石学报2010，26，4： | 132 |
| 2 | 南阿尔金茫崖地区花岗岩类锆石SHRIMP U-Pb定年、Lu-Hf同位素特征及岩石成因显示文摘南阿尔金茫崖地区早古生代花岗岩锆石SHRIMP U-Pb定年结果表明,阿克提山花岗岩为264±1Ma,柴水沟花岗岩分别为404±5Ma、406±4Ma,其中的辉绿岩为454±4Ma,常春沟花岗岩分别为411±5Ma、406±3Ma,茫崖镇北石英闪长岩为466±5Ma,阿卡龙山花岗岩为469±6Ma。锆石Lu-Hf同位素分析表明,εHf(t)值大多数为正值,少数继承性锆石为负值,反映了它们的源岩以新生地壳为主,同时,也混有少量的古大陆壳的成分。结合区域地质特征和各岩体的岩石地球化学特征,将南阿尔金茫崖地区早古生代花岗质岩浆活动划分为3期,第一期(465~469Ma)岩石组合为石英闪长岩+花岗闪长岩+花岗岩,具有岛弧火成岩的地球化学属性,其形成可能与洋壳的俯冲作用有关;第二期(404~411Ma)岩石组合为花岗闪长岩+二长花岗岩+正长花岗岩,具有A型花岗岩的地球化学特征,可能与板块碰撞后造山带块体均衡调整有关,第三期(264Ma)岩石组合为石英闪长岩+二长花岗岩+正长花岗岩,也具有I型花岗岩的特征,可能与阿尔金断裂的活动有关。 | 吴才来 郜源红 雷敏 秦海鹏 刘春花 李名则 B Ronald FROST Joseph L WOODEN | 2014 | 岩石学报2014，30，8： | 56 |
| 3 | 都兰花岗岩锆石SHRIMP定年及柴北缘超高压带花岗岩年代学格架显示文摘柴北缘超高压带东端都兰地区花岗岩锆石SHRIMP U-Pb定年结果表明,野马滩东岩体的年龄为(406.6±3.5)Ma,巴立给哈滩西岩体的年龄分别为(407.3±4.3)和(397±6)Ma,水文站北岩体的年龄分别为(404.5±4.0)和(397.0±3.7)Ma,水文站南岩体的年龄为(380.5±5.0)Ma,察察公麻岩体的年龄分别为(382.5±3.6)和(372.5±2.8)Ma.从年龄上看,这些花岗岩明显地分为两期:早期的为407-397 Ma,晚期的为383-373 Ma.它们主要为准铝质-弱过铝质的石英闪长岩、花岗闪长岩和二长花岗岩.岩石地球化学研究表明,大多数样品为钙碱性系列,少数样品为钙性或碱钙性系列,其中,早期花岗岩的87Sr/86Sr比值(0.7082-0.7110)和模式年龄(T2DM=1.41-1.90 Ga)高于晚期花岗岩(0.7072-0.7091,T2DM=1.07-1.38 Ga),但晚期花岗岩的εNd(t)值(0.6- -3.0)高于早期花岗岩(-3.2- -9.3),表明早期花岗岩可能起源于早中元古代的大陆壳;而晚期花岗岩起源于晚中元古代玄武质地壳.结合区域地质构造特征,可以认为,早期花岗岩的形成与俯冲板块的断离并折返有关,而晚期花岗岩的形成与造山带岩石圈地幔拆沉作用有关. | 吴才来 郜源红 李兆丽 雷敏 秦海鹏 李名则 刘春花 Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | 中国科学:地球科学2014，44，10： | 27 |
| 4 | Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle. | WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | Science China Earth Sciences2014，57，12： | 21 |
| 5 | Gastrointestinal complications of diabetes mellitus显示文摘Diabetes mellitus affects virtually every organ system in the body and the degree of organ involvement depends on the duration and severity of the disease,and other co-morbidities.Gastrointestinal(GI) involvement can present with esophageal dysmotility,gastro-esophageal reflux disease(GERD),gastroparesis,enteropathy,non alcoholic fatty liver disease(NAFLD) and glycogenic hepatopathy.Severity of GERD is inversely related to glycemic control and management is with prokinetics and proton pump inhibitors.Diabetic gastroparesis manifests as early satiety,bloating,vomiting,abdominal pain and erratic glycemic control.Gastric emptying scintigraphy is considered the gold standard test for diagnosis.Management includes dietary modifications,maintaining euglycemia,prokinetics,endoscopic and surgical treatments.Diabetic enteropathy is also common and management involves glycemic control and symptomatic measures.NAFLD is considered a hepatic manifestation of metabolic syndrome and treatment ismainly lifestyle measures,with diabetes and dyslipidemia management when coexistent.Glycogenic hepatopathy is a manifestation of poorly controlled type 1 diabetes and is managed by prompt insulin treatment.Though GI complications of diabetes are relatively common,awareness about its manifestations and treatment options are low among physicians.Optimal management of GI complications is important for appropriate metabolic control of diabetes and improvement in quality of life of the patient.This review is an update on the GI complications of diabetes,their pathophysiology,diagnostic evaluation and management. | Babu Krishnan Shithu Babu Jessica Walker Adrian B Walker Joseph M Pappachan | 2013 | World Journal of Diabetes2013，4，3： | 10 |
| 6 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 7 | 溃疡性结肠炎显示文摘溃疡性结肠炎(ulcerativecolitis,uc)是一种消化道炎症性疾病,病变主要位于结直肠。UC好发于青年人,发达国家的人群患病率较高。UC表现为结直肠弥漫性、连续性浅表炎症,以及相应的组织学改变。下消化道内镜或影像检查可以明确诊断。目前尚未发现UC的明确病因,其发病机制与遗传易感个体的结肠内环境变化有关,具有慢性、终身、易复发的病程特点。 | Alexander C Ford Paul Moayyedl Steven B Hanauer Joseph B Kirsner 谭蓓 吴东 | 2017 | 英国医学杂志中文版2017，20，7： | 7 |
| 8 | Can tranexamic acid change preoperative anemia management during total joint arthroplasty?显示文摘AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of patients presented with preoperative anemia. No patients in either group required a blood transfusion or had an acute postoperative complication. For nonanemic patients, the average change in hemoglobin was 1.85 ± 0.79 g/d L. For anemic patients, the average change in hemoglobin was 1.09 ± 0.58 g/d L. Between the two groups, the hemoglobin difference of 0.76 g/d L was significant(P < 0.001). CONCLUSION: TXA administration results in low transfusion and complication rates and may be a useful adjunct for TJA patients with preoperative anemia. | Duy L Phan Joseph B Rinehart Ran Schwarzkopf | 2015 | World Journal of Orthopedics2015，6，7： | 5 |
| 9 | TG13 flowchart for the management of acute cholangitis and cholecystitis显示文摘 | Fumihiko Miura Tadahiro Takada Steven M. Strasberg Joseph S. Solomkin Henry A. Pitt Dirk J. Gouma O. James Garden Markus W. Büchler Masahiro Yoshida Toshihiko Mayumi Kohji Okamoto Harumi Gomi Shinya Kusachi Seiki Kiriyama Masamichi Yokoe Yasutoshi Kimura | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，1： | 4 |
| 10 | Mission impossible completed:unlocking the nomenclature of the largest and most complicated subgenus of Cortinarius,Telamonia显示文摘So far approximately 144,000 species of fungi have been named but sequences of the majority of them do not exist in the public databases.Therefore,the quality and coverage of public barcode databases is a bottleneck that hinders the study of fungi.Cortinarius is the largest genus of Agaricales with thousands of species world-wide.The most diverse subgenus in Cortinarius is Telamonia and its species have been considered one of the most taxonomically challenging in the Agaricales.Its high diversity combined with convergent,similar appearing taxa have earned it a reputation of being an impossible group to study.In this study a total of 746 specimens,including 482 type specimens representing 184 species were sequenced.Also,a significant number of old types were successfully sequenced,105 type specimens were over 50 years old and 18 type specimens over 100 years old.Altogether,20 epi-or neotypes are proposed for recently commonly used older names.Our study doubles the number of reliable DNA-barcodes of species of C.subgenus Telamonia in the public sequence data-bases.This is also the first extensive phylogenetic study of the subgenus.A majority of the sections and species are shown in a phylogenetic context for the first time.Our study shows that nomenclatural problems,even in difficult groups like C.subgenus Telamonia,can be solved and consequently identification of species based on ITS barcodes becomes an easy task even for non-experts of the genus. | Kare Liimatainen Tuula Niskanen Bálint Dima Joseph F.Ammirati Paul M.Kirk Ilkka Kytövuori | 2020 | Fungal Diversity2020，，5： | 4 |
| 11 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 12 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 13 | Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction显示文摘 | Jeffrey L Anderson John F Carlquist Joseph B Muhlestein Benjamin D Horne Sidney P Elmer | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 14 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 15 | Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa显示文摘This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their classification.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,RBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate ranks.Wherever new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative morphs.The new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,Neomassaria,Neomassarina,Neotruncatella,Paracapsulospora and Pseudophaeosphaeria.The new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,An.thailandica,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaeronema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,Co.nymphatus,Co.pseudobulliardioides,Co.tenuifulvescens,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,De.cirsii,Diaporthe aseana,Di.garethjonesii,Distoseptispora multiseptata,Dis.tectonae,Dis.tectonigena,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,H.oblongispora,Hermatomyces subiculosa,Juncaceicola italica,Lactarius dirkii,Lentithecium unicellulare,Le.voraginesporum,Leptosphaeria cirsii,Leptosphaeria irregularis,Leptospora galii,Le.thailandica,Lindgomyces pseudomadisonensis,Lophiotrema bambusae,Lo.fallopiae,Meliola citri-maximae,Minimelanolocus submersus,Montagnula cirsii,Mortierella fluviae,Muriphaeosphaeria ambrosiae,Neodidymelliopsis ranunculi,Neomassaria fabacearum,Neomassarina thailandica,Neomicrosphaeropsis cytisi,Neo.cytisinus,Neo.minima,Neopestalotiopsis cocoe¨s,Neopestalotiopsis musae,Neoroussoella lenispora,Neotorula submersa,Neotruncatella endophytica,Nodulosphaeria italica,Occultibambusa aquatica,Oc.chiangraiensis,Ophiocordyceps hemisphaerica,Op.lacrimoidis,Paracapsulospora metroxyli,Pestalotiopsis sequoiae,Peziza fruticosa,Pleurotrema thailandica,Poaceicola arundinis,Polyporus mangshanensis,Pseudocoleophoma typhicola,Pseudodictyosporium thailandica,Pseudophaeosphaeria rubi,Purpureocillium sodanum,Ramariopsis atlantica,Rhodocybe griseoaurantia,Rh.indica,Rh.luteobrunnea,Russula indoalba,Ru.pseudoamoenicolor,Sporidesmium aquaticivaginatum,Sp.olivaceoconidium,Sp.pyriformatum,Stagonospora forlicesenensis,Stagonosporopsis centaureae,Terriera thailandica,Tremateia arundicola,Tr.guiyangensis,Trichomerium bambusae,Tubeufia hyalospora,Tu.roseohelicospora and Wojnowicia italica.New combinations are given for Hermatomyces mirum and Pallidocercospora thailandica.A neotype is proposed for Cortinarius fulvescens.Reference specimens are given for Aquaphila albicans,Leptospora rubella,Platychora ulmi and Meliola pseudosasae,while new host or distribution records are provided for Diaporthe eres,Di.siamensis,Di.foeniculina,Dothiorella iranica,Do.sarmentorum,Do.vidmadera,Helvella tinta and Vaginatispora fuckelii,with full taxonomic details.An asexual state is also reported for the first time in Neoacanthostigma septoconstrictum.This paper contributes to a more comprehensive update and improved identification of many ascomycetes and basiodiomycetes. | Kevin D.Hyde Sinang Hongsanan Rajesh Jeewon D.Jayarama Bhat Eric H.C.McKenzie E.B.Gareth Jones Rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake Mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-Neto Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Patinjareveettil Manimohan Ausana Mapook Tuula Niskanen Chada Norphanphoun Moslem Papizadeh Rekhani H.Perera Chayanard Phukhamsakda Christian Richter AndréL.C.Mde A.Santiago E.Ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.M.D.S.Tennakoon Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali Mohammad A.Amoozegar Lidia Silva Araujo-Neta Joseph F.Ammirati Abhishek Baghela R.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima Rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando Mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul M.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu Robert Lücking Gianfranco Medardi Peter E.Mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil Raj Mateus A.Reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli Marc Stadler Mohammad Reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu | 2016 | Fungal Diversity2016，，5： | 2 |
| 16 | Apolipoprotein E in Alzheimer’s disease and other neurological disorders显示文摘 | Philip B Verghese Joseph M Castellano David M Holtzman | 2011 | Lancet Neurology2011，，3： | 2 |
| 17 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 18 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 19 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 20 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
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