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| 1 | Cancer in inflammatory bowel disease显示文摘Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Many of the molecular alterations responsible for sporadic colorectal cancer, namely chromosomal instability, microsatellite instability, and hypermethylation, also play a role in colitis-associated colon carcinogenesis. Colon cancer risk in inflammatory bowel disease increases with longer duration of colitis, greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel. Chemoprevention includes aminosalicylates, ursodeoxycholic acid, and possibly folic acid and statins. To reduce CRC mortality in IBD, colonoscopic surveillance with random biopsies remains the major way to detect early mucosal dysplasia. When dysplasia is confirmed, proctocolectomy is considered for these patients. Patients with small intestinal Crohn’s disease are at increased risk of small bowel adenocarcinoma. Ulcerative colitis patients with total proctocolectomy and ileal pouch anal- anastomosis have a rather low risk of dysplasia in the ileal pouch, but the anal transition zone should be monitored periodically. Other extra intestinal cancers, such as hepatobiliary and hematopoietic cancer, have shown variable incidence rates. New endoscopic and molecular screening approaches may further refine our current surveillance guidelines and our understanding of the natural history of dysplasia. | Steven H Itzkowitz | 2008 | World Journal of Gastroenterology2008，14，3： | 33 |
| 2 | AGA Technical Review on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease显示文摘 | Francis A. Farraye Robert D. Odze Jayne Eaden Steven H. Itzkowitz | 2010 | Gastroenterology2010，，2： | 5 |
| 3 | Customers and cash: How relationships affect suppliers’ cash holdings显示文摘 | Jennifer Itzkowitz | 2013 | Journal of Corporate Finance2013，，： | 4 |
| 4 | Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study显示文摘 | Roopali Bansal Gupta Noam Harpaz Steven Itzkowitz Sabera Hossain Sierra Matula Asher Kornbluth Carol Bodian Thomas Ullman | 2007 | Gastroenterology2007，，4： | 3 |
| 5 | Precancerous lesions in inflammatory bowel disease显示文摘 | Noam Harpaz Stephen C. Ward Claudia Mescoli Steven H. Itzkowitz Alexandros D. Polydorides | 2013 | Best Practice & Research Clinical Gastroenterology2013，，2： | 3 |
| 6 | Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis显示文摘 | Thomas Ullman Victoria Croog Noam Harpaz David Sachar Steven Itzkowitz | 2003 | Gastroenterology2003，，5： | 2 |
| 7 | Customers and cash: how relationships affect suppliers' cash holdings 显示文摘 | Itzkowitz J | 2013 | Journal of Corporate Finance2013，，19： | 1 |
| 8 | AGA Medical Position Statement on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease显示文摘 | Francis A. Farraye Robert D. Odze Jayne Eaden Steven H. Itzkowitz | 2010 | Gastroenterology2010，，2： | 1 |
| 9 | Muein gene expression in colonic tissues and cell 11nes显示文摘 | Ogata S Uehara H Chen A Itzkowitz SH | 1992 | Cancer Res1992，52，： | 1 |
| 10 | Pancreaticoduodenectomy in Elderly Adults: Is It Justified in Terms of Mortality, Long‐Term Morbidity, and Quality of Life?显示文摘 | Fabian Gerstenhaber Julie Grossman Nir Lubezky Eran Itzkowitz Ido Nachmany Ronen Sever Menahem Ben‐Haim Richard Nakache Joseph M. Klausner Guy Lahat | 2013 | J Am Geriatr Soc2013，，8： | 1 |
| 11 | Customers and cash: How relationships affect suppliers’ cash holdings显示文摘 | Jennifer Itzkowitz | 2013 | Journal of Corporate Finance2013，，： | 1 |
| 12 | Gastroenterology, feacal DNA versus fecal oc- cult blood for colorectal-cancer screening in an average risk population显示文摘 | IMPERIALE T F RANSOHOFF D F ITZKOWITZ S H | 2004 | N Engl J Med2004，351，： | 1 |
| 13 | Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis:a cohort study显示文摘 | Gupta RB Harpaz N Itzkowitz S | | 0，，04： | 1 |
| 14 | Fecal DNA versus fecal occult blood for colorectal - cancer screening in an average - risk population显示文摘 | Imperiale T F Ransohoff D F Itzkowitz S H | 2004 | N Engl J Med2004，351，26： | 1 |
| 15 | Intestinal inflammation and cancer显示文摘 | ULLMAN TA ITZKOWITZ SH | 2011 | Gastroenterology2011，140，： | 1 |
| 16 | Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer显示文摘 | Tomer Cooks Ioannis S. Pateras Ohad Tarcic Hilla Solomon Aaron J. Schetter Sylvia Wilder Guillermina Lozano Eli Pikarsky Tim Forshew Nitzan Rozenfeld Noam Harpaz Steven Itzkowitz Curtis C. Harris Varda Rotter Vassilis G. Gorgoulis Moshe Oren | 2013 | Cancer Cell2013，，5： | 1 |
| 17 | MUC1 expression in prostate carcinoma:correlation with grade and stage显示文摘 | Kirschenbaum A Itzkowitz S H Wang J P | 1999 | Mol Urol1999，3，3： | 1 |
| 18 | Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors显示文摘 | Masayuki Fukata Anli Chen Arunan S. Vamadevan Jason Cohen Keith Breglio Suneeta Krishnareddy David Hsu Ruliang Xu Noam Harpaz Andrew J. Dannenberg Kotha Subbaramaiah Harry S. Cooper Steven H. Itzkowitz Maria T. Abreu | 2007 | Gastroenterology2007，，6： | 1 |
| 19 | Expression of Tn , sialosyl- Tn , and T antigens in human colon cancer 显示文摘 | Itzkowitz SH Yuan M Montgomery CK | 1989 | Cancer Res1989，49，1： | 1 |
| 20 | <ce:link locator='fx1'/> Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study显示文摘 | Roopali Bansal Gupta Noam Harpaz Steven Itzkowitz Sabera Hossain Sierra Matula Asher Kornbluth Carol Bodian Thomas Ullman | 2007 | Gastroenterology2007，，4： | 1 |
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