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| 1 | Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis显示文摘BACKGROUND Liver cirrhosis is a significant source of morbidity and mortality worldwide.The disease is usually indolent and asymptomatic early in its course while many cirrhotic patients are diagnosed late when severe complications occur.A major challenge is to diagnose advanced fibrosis as early as possible,using simple and non-invasive diagnostics tools.Thrombocytopenia represents advanced fibrosis and portal hypertension(HTN)and most non-invasive scores that predict liver fibrosis incorporate platelets as a strong risk factor.However,little is known about the association between longitudinal changes in platelet counts(PTC),when still within the normal range,and the risk of cirrhosis.AIM To explore whether platelet counts trajectories over time,can predict advanced liver fibrosis across the different etiologies of liver diseases.METHODS A nested case-control study utilizing a large computerized database.Cirrhosis cases(n=5258)were compared to controls(n=15744)matched for age and sex at a ratio of 1:3.All participants had multiple laboratory measurements prior to enrollment.We calculated the trends of PTC,liver enzymes,bilirubin,international normalized ratio,albumin and fibrosis scores(fibrosis-4 and aspartate transaminase-to-platelet ratio index)throughout the preceding 20 years prior to cirrhosis diagnosis compared to healthy controls.The association between PTC,cirrhosis complications and fibrosis scores prior to cirrhosis diagnosis was investigated.RESULTS The mean age in both groups was 56(SD 15.8).Cirrhotic patients were more likely to be smokers,diabetic with chronic kidney disease and had a higher prevalence of HTN.The leading cirrhosis etiologies were viral,alcoholic and fatty liver disease.The mean PTC decreased from 240000/μL to 190000/μL up to 15 years prior to cirrhosis diagnosis compared to controls who’s PTC remained stable around the values of 240000/μL.This trend was consistent regardless of sex,cirrhosis etiology and was more pronounced in patients who developed varices and ascites.Compared to controls whose values remained in the normal range,in the cirrhosis group aspartate aminotransferase and alanine aminotransferase,increased from 40 U/L to 75 U/L and FIB-4 increased gradually from 1.3 to 3 prior to cirrhosis diagnosis.In multivariable regression analysis,a decrease of 50 units in PTC was associated with 1.3 times odds of cirrhosis(95%CI 1.25-1.35).CONCLUSION In the preceding years before the diagnosis of cirrhosis,there is a progressive decline in PTC,within the normal range,matched to a gradual increase in fibrosis scores. | Neta Gotlieb Naama Schwartz Shira Zelber-Sagi Gabriel Chodick Varda Shalev Oren Shibolet | 2020 | World Journal of Gastroenterology2020，26，38： | 3 |
| 2 | ‘Cancer associated fibroblasts’ – more than meets the eye显示文摘 | Shalom Madar Ido Goldstein Varda Rotter | 2013 | Trends in Molecular Medicine2013，，： | 2 |
| 3 | Increased serum levels of YKL-40 in patients with inflammatory bowel disease显示文摘 | Ioannis E. Koutroubakis Efthymia Petinaki Philippos Dimoulios Emmanouel Vardas Maria Roussomoustakaki Antonios N. Maniatis Elias A. Kouroumalis | 2003 | International Journal of Colorectal Disease2003，，3： | 2 |
| 4 | Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation显示文摘AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective 'Fibroscore Study' in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as 'fast fi brosers' and 116 as 'slow fi brosers'; 13% of the 'fast fi brosers' carried the PT20210 mutation as compared with 5.5% of the 'slow fi brosers', with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for 'fast' liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients. | Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 5 | Mutant p53-a potential player in shaping the tumor-stroma crosstalk显示文摘A plethora of studies suggest that the non-transformed cellularand non-ceHular comp on ents of the tumor,collectively known as the tumor microenvironment,have a significa nt impact on the tumorigenic process.It was suggested that the microenvironment,which initially restricts tumor development,is recruited by the tumor and main tains a crosstalk that further promotes cancer progression. | Yan Stein Ronit Aloni-Grinstein Varda Rotter | 2019 | Journal of Molecular Cell Biology2019，11，7： | 2 |
| 6 | Accurate Assessment of Patient Effective Radiation Dose and Associated Detriment Risk From Radiofrequency Catheter Ablation Procedures显示文摘 | Kostas Perisinakis John Damilakis Nicholas Theocharopoulos Emmanouel Manios Panayiotis Vardas Nicholas Gourtsoyiannis | 2001 | Circulation: Journal of the American Heart Association2001，，1： | 2 |
| 7 | Metabolic engineering of astaxanthin production in tobacco flowers显示文摘 | VARDA M MARK H IRIS P | 2000 | Nat Biotechnol2000，18，： | 1 |
| 8 | Amiod- atone as a first - choice drug for restoring sinus rhythm in patients with artrial fibrillation; a randomized controlled study显示文摘 | Vardas PE Koehiadakis GE Igoumenidis NE | 2000 | Chest2000，117，6： | 1 |
| 9 | 2010 Focused Up date of ESC Guidelines on device therapy in heart failure显示文摘 | Dickstein K Vardas P E Auricchio A | 2010 | Euro pean Heart Journal2010，31，21： | 1 |
| 10 | Bradykinin in the treatment of arterial hy- pertension :friend or foe显示文摘 | Marketou ME Vardas PE | 2012 | Hellenic J Cardiol2012，53，2： | 1 |
| 11 | The epidemiology of respiratory syncytial virus (RSV) infections in South African children显示文摘 | VARDAS E BLAAUW D MCANERNEY J | 1999 | S Aft Med J1999，89，10： | 1 |
| 12 | Overview of brain polyamine-stress-response: Regulation,development, and modulation by lithium and role in cell survival显示文摘 | Gad MG Varda HG | 2003 | Cellular and Molecular Neurobiology2003，23，3： | 1 |
| 13 | Amiodarone as a first-choice for restoring sinus rhythm in patients with atrial fibrillation:a randomized,controlled study显示文摘 | VARDAS PE KOCHIADAKIS GE IGOUMENIDIS NE | 2000 | Chest2000，117，6： | 1 |
| 14 | Metabolic engineering of astaxanthin production in tobacco flowers显示文摘 | VARDA M MARK H IRIS P | 2000 | Nature Biotechnology2000，18，8： | 1 |
| 15 | Twenty-four-hour ambulatory blood pressure monitoring in infants and toddlers显示文摘 | Varda N M Gregoric A | 2005 | Pediatr Nephrol2005，20，6： | 1 |
| 16 | Sequence analysis of the nudeocapsid gene of measles virus isolates from south Africa identifies a new genotype显示文摘 | Kreis S Vardas E Whistler T | 1997 | J Gen Virol1997，78，7： | 1 |
| 17 | External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents显示文摘 | Vardas E Ginliano AR Goldstone S | 2011 | J Infect Dis2011，203，： | 1 |
| 18 | Balthazar computed tomography severity index is superior to Ranson criteria and APACHE Ⅱ and Ⅲ scoring systems in predicting acute pancreatitis outcome显示文摘 | Chatzicostas C Roussomoustakaki M Vardas E | 2003 | J Clin Gastroenterol2003，36，3： | 1 |
| 19 | Guide- lines for cardiac pacing and cardiac resynehronization therapy 显示文摘 | Vardas PE Auricehio A Blanc JJ et ah The task force for cardiac pacing and cardiac resynehronization therapy of the European Society of Cardiology | 2007 | Eur Heart J2007，28，18： | 1 |
| 20 | The ESC committee for practice guidelines(CPG) 显示文摘 | Dickstein K Vardas PE Auricchio A | 2013 | Eur Heart J2013，34，10： | 1 |
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