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| 1 | Theoretical analyses and numerical experiments of variational assimilation for one-dimensional ocean temperature model with techniques in inverse problems显示文摘In the present work, the data assimilation problem in meteorology and physical oceanography is re-examined using the variational optimal control approaches in combination with regularization techniques in inverse problem. Here the estimations of the initial condition, boundary condition and model parameters are performed simultaneously in the framework of variational data assimilation. To overcome the difficulty of ill-posedness, especially for the model parameters distributed in space and time, an additional term is added into the cost functional as a stabilized functional. Numerical experiments show that even with noisy observations the initial conditions and model parameters are recovered to an acceptable degree of accuracy. | HUANG Sixun1,2, HAN Wei1 & WU Rongsheng2 1. P. O. Box 003, Nanjing 211101,China 2. Key Laboratory of Meso-Scale Severe Weather /MOE, Department of Atmospheric Sciences, Nanjing University, Nanjing 210093, China Correspondence should be addressed to Huang Sixun | 2004 | Science China Earth Sciences2004，47，7： | 18 |
| 2 | Vertical dynamic and thermodynamic characteristics of urban lower boundary layer and its relationship with aerosol concentration over Beijing显示文摘By utilizing observational data from a 325 m tower of the Institute of Atmospheric Physics (IAP), Chinese Academy of Sciences (CAS) on March 19-29, 2001 and August 11-25, 2003, a comprehensive study was conducted on the vertical dynamical and thermodynamic characteristics of the urban lower boundary layer (ULBL) and its relationship with aerosol concentration over Beijing. Firstly, a comparative analysis was made on the gradient data (wind, temperature and humidity), ultrasonic data (atmospheric turbulences) and air-quality observations at different tower heights (47, 120 and 280 m). Secondly, a diagnosis was made to reveal the major features of normalized variances of velocity and temperature, turbulence kinetic energy as well as their relationship with aerosol concentrations. Furthermore, the characteristics of the ULBL vertical structure and the TSP concentration/distribution variations during a sand/dust weather process were also analyzed. The outcome of the study showed that under unstable stratification, the normalized variances of velocity (σu/u*, σv/u*, σw/u*) and temperature (σT/T*) at 47 and 120 m heights fit the Monin-Obukhov similarity (MOS) framework and the fitting formulas were given out accordingly. According to the stratification parameter (z′/L), the stable ULBL could be divided into 2 zones. With z′/L<0.1, it was a weakly stable zone and MOS framework was applicable. The other was a highly stable zone with z′/L>0.1 and the normalized velocity variances tended to increase along with higher stability, but it remained constant for normalized temperature variances. At daytime, the near-surface layer includes two heights of 47 and 120 m, while 280 m has been above it. The ULBL analysis in conjunction with a sand/dust weather process in Beijing in March 2001 indicated that the maximum concentration of Total Suspended Particulates (TSP) at 320 m reached 913.3 μg/m3 and the particles were transported from the upper to lower ULBL, which was apparently related to the development process of a low-level jet and its concomitant strong sinking motion. | ZHOU Mingyu, YAO Wenqing, XU Xiangde & YU Haiqing State Key Laboratory on Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China National Marine Environment Forecasting Center, Beijing 100081, China National Meteorological Center, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 11 |
| 3 | Possible mechanism of the effect of convection over Asian-Australian “land bridge” on the East Asian summer monsoon onset显示文摘The Asian-Australian “land bridge” is an area with the most vigorous convection in Asian monsoon region in boreal spring, where the onset and march of convection are well associated with the onset of East Asian summer monsoon. The convection occurs over Indo-China Peninsula as early as mid-April, which exerts critical impact on the evolution of monsoon circulation. Before mid-April there are primarily sensible heatings to the atmosphere over Indo-China Peninsula and Indian Peninsula, so the apparent heating ratios over them decrease with height. However, after mid-April it changes into latent heating over Indo-China Peninsula due to the onset of convection, and the apparent heating ratio increases with height in mid- and lower troposphere. The vertical distribution of heating ratio and its differences between Indo-China Peninsula and Indian Peninsula are the key factors leading to the splitting of boreal subtropical high belt over the Bay of Bengal. Such mechanism is strongly supported by the fact that the evolution of the vertical heating ratio gradient above Indo-China Peninsula leads that of 850 hPa vorticity over the Bay of Bengal. Convections over Indo-China Peninsula and its surrounding areas further increase after the splitting. Since then, there is a positive feedback lying among the convective heating, the eastward retreat of the subtropical high and the march of monsoon, which is a possible mechanism of the advance of summer monsoon and convection from Indo-China Peninsula to South China Sea. | HE Jinhai1, WEN Min2, DING Yihui3 & ZHANG Renhe2 1. Jiangsu Key Laboratory of Meteorological Disaster (KLME), Nanjing Institute of Meteorology, Nanjing University of Informa- tion Science and Technology, Nanjing 210044, China 2. State Key Laboratory of Severe Weather (LaSW), Chinese Academy of Meteorological Sciences, Beijing 100081, China 3. National Climate Center, Chinese Meteorological Administration, Beijing 100081, China | 2006 | Science China Earth Sciences2006，49，11： | 10 |
| 4 | A semi-implicit semi-Lagrangian global nonhydrostatic model and the polar discretization scheme显示文摘The Global/Regional Assimilation and PrEdiction System(GRAPES) is a newly developed global non-hydrostatic numerical prediction model,which will become the next generation medium-range opera-tional model at China Meteorological Administration(CMA).The dynamic framework of GRAPES is featuring with fully compressible equations,nonhydrostatic or hydrostatic optionally,two-level time semi-Lagrangian and semi-implicit time integration,Charney-Phillips vertical staggering,and complex three-dimensional pre-conditioned Helmholtz solver,etc.Concerning the singularity of horizontal momentum equations at the poles,the polar discretization schemes are described,which include adoption of Arakawa C horizontal grid with ν at poles,incorporation of polar filtering to maintain the computational stability,the correction to Helmholtz equation near the poles,as well as the treatment of semi-Lagrangian interpolation to improve the departure point accuracy,etc.The balanced flow tests validate the rationality of the treatment of semi-Lagrangian departure point calculation and the polar discretization during long time integration.Held and Suarez tests show that the conservation proper-ties of GRAPES model are quite good. | YANG XueSheng1,CHEN JiaBin2,HU JiangLin1,CHEN DeHui1,SHEN XueShun1,ZHANG HongLiang1 1 State Key Laboratory of Severe Weather,Chinese Academy of Meteorological Sciences,Beijing 100081,China 2 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics,Institute of Atmospheric Physics,Beijing 100029,China | 2007 | Science China Earth Sciences2007，50，12： | 9 |
| 5 | Urban effects and summer thunderstorms in a tropical cyclone affected situation over Guangzhou city显示文摘With data mainly from Guangzhou mesonet Automatic Weather Stations(AWS),Guangzhou Doppler Radar and satellite TBB data,characteristics and evolution of the urban heat island(UHI) over Guang-zhou City were analyzed in a tropical cyclone affected situation for early August 2005.In particular,two thunderstorms occurring during this period respectively at the night of 4 August and in the afternoon of 7 August were investigated to study the relationships between the development of thunderstorms and the UHI.Results showed that two thunderstorms were associated with the UHI effects.UHI induced local air convergence and initiated the thunderstorm convections.Both cases showed a general agreement in time and space for the locations of maximum UHI,convergence,convection,and pre-cipitation.Convection was found to be more favorable to developing in time periods and locations with stronger intensity of UHI.Analysis also showed that,due to the urban effects,both thunderstorms got strengthened when moving over Guangzhou City,with maximum radar echoes observed right over the urban area and precipitation located within the city.All these features reveal that two thunderstorms were urban-induced storms. | MENG WeiGuang1,3,YAN JingHua1 & HU HaiBo2 1 Institute of Tropical and Marine Meteorology,Chinese Meteorological Administration(CMA),Guangzhou 510080,China 2 Institute of Urban Meteorology,CMA,Beijing 100089,China 3 State Key Laboratory of Severe Weather,Chinese Academy of Meteorological Sciences,Beijing 100081,China | 2007 | Science China Earth Sciences2007，50，12： | 8 |
| 6 | Rapid detection of sepsis complicating acute necrotizing pancreatitis using polymerase chain reaction显示文摘INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis and the therapeutic measuses taken by the clinicians ,the patients can pass through the critical carry stages ,and then the septic complication caused by rtanslocated bacteria, mostly gram-negative microbes from the intestines ensues[1]. | Wei Zhong Zhang1 Tian Quan Han2 Yao Qing Tang2 Sheng Dao Zhang2 1Department of Surgery. Huangyan First Hospital, Huangyan 318020, Zhejiang Province. China 2Department of Surgery. Ruijin Hospital. Shanghai Second Medical University. Shanghai 200025. ChinaDr. Wei Zhong Zhang, graduated from Shanghai Second MedicalUniversity receiving master degree of surgery in 1999 he is devoted to basic and clinical investigation on severe acute pancreatitis and has one paper published. | 2001 | World Journal of Gastroenterology2001，7，2： | 7 |
| 7 | Effect of BMI on outcomes of surgical treatment for tibial plateau fractures: A comparative retrospective case series study显示文摘 | Yasar Mahsut Dincel All Oner Yavuz Arikan Sever Caglar Rasit Ozcafer Mehmet Akif Gulec | 2018 | Chinese Journal of Traumatology2018，21，2： | 7 |
| 8 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 9 | Changes in the spatial scale of Beijing UHI and urban development显示文摘The seasonal and interannual variations of Beijing urban heat island (UHI) are investigated in this paper using the temperature data from 1960 to 2000 at 20 meteorological stations in the Beijing region, and then the relationship between the intensity and spatial scale of UHI and Beijing urbanization indices is analyzed and discussed. Main conclusions are the followings. First, Beijing UHI shows obvious seasonal variations, and it is strongest in winter, next in spring and autumn, and least in summer. The seasonal variation of the UHI mainly occurs in the urban area. The UHI intensity at the center of Beijing is more than 0.8℃ in winter, and only 0.5℃ in summer. Second, the intensity of Beijing HUI exhibits a clear interannual warming trend with its mean growth rate (MGR) being 0.3088℃/10 a. The MGR of HUI is largest in winter, next in spring and autumn, and least in summer, and the urban temperature increase makes a major contribution to the growth of HUI intensity. Third, since the Reform and Opening, the urbanization indices have grown several ten times or even one hundred times, the intensity of HUI has increased dramatically, and its spatial scale also expanded distinctively along with the expansion of urban architectural complexes. Fourth, the interannual variation of urbanization indices is very similar with that of HUI intensity, and their linear correlation coefficients are significant at a more than 0.001 confidence level. | YU Shuqiu, BIAN Lingen & LIN Xuechun State Key Laboratory on Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China National Climate Center, China Meteorological Administration, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 5 |
| 10 | Analysis to significant climate change in aerosol influence domain of Beijing and its peripheral areas by EOF mode显示文摘Using the total ozone mapping spectrometer (TOMS) aerosol optical depth (AOD)data and the sunshine duration, fog days, Iow cloud cover (LCC), etc. meteorological data in 1979-2000 in North China, as well as empirical orthogonal function (EOF) mode statistical analyses method, the winter aerosol distributive character of Beijing and peripheral city agglomeration and its influence effect on regional climate are investigated in this paper, especially the relation between aerosol influence effect and distinct change regions of eigenvectors of EOF mode. It is found from analyzing the regional distribution of the long-term averaged winter TOMS AOD that there is a large-scale relatively stable high value zone of aerosol concentration in the valley of the Beijing and peripheral U-shape megarelief. A high correlation area of AOD between Beijing and its southern peripheral exists in winter, and in this significant region of aerosol interaction, there is 'in-phase' character of the interannual variations of winter AOD, fog days, and LCCs. It indicates that the variations of aerosol in Beijing and its peripheral areas have impacts on interannual changes of fog days and LCCs in this area. The EOF analyses of the meteorological data further reveal the climate change regions and long-term trends of winter sunshine duration-reducing, and LCC- and fog days-increasing in North China. The areas of significant changes of the first EOF eigenvectors (FEE) of sunshine duration, fog days, LCCs almost superpose on corresponding marked regions of interdecadal differences between the 1990s and 1980s, and all accord with the S-N zonal high value pattern and high correlation region of winter AOD in Beijing and its peripheral areas. Interannual variations of their associated time coefficients (ATC) are in phase with that of regional mean AOD, and both of them have a secular rising trend. Results by EOF mode analyses depict the regional climatic change principal character of winter sunshine duration-reducing, and LCC- and fog days-increasing in peripheral areas to the south of Beijing, and reveal the regional influence effect of aerosol, i.e. the high value zone of long-term averaged winter AOD, significant change regions of FEE of sunshine duration, fog days, and LCC all lie in peripheral city agglomeration to the south of Beijing. These distributive features above suggest that there exists a regional strengthening trend of aerosol climatic effect within influence domain in peripheral city agglomeration to the south of Beijing. | SHI Xiaohui, XU Xiangde, ZHANG Shengjun & DING Guoan State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China Nanjing University of Information Science and Technology, Nanjing 210044, China | 2005 | Science China Earth Sciences2005，48，z2： | 5 |
| 11 | 聚合物抛光垫修整和抛光的研究显示文摘通过试验了解聚合物抛光垫的修整和抛光原理,分别用尼龙、聚碳酸酯和聚氨酯在含3%氧化铝颗粒的抛光液中与铜销对磨,测定修整后的抛光垫的表面性能,测量抛光试验中抛光垫的磨损和摩擦因数。结果表明,聚碳酸酯和聚氨酯抛光垫的接触角随表面粗糙度的增大而增大,尼龙则趋向于相反的规律;修整后的表面粗糙度对尼龙和聚碳酸酯抛光垫磨损机制的影响要大于对聚氨酯抛光垫磨损机制的影响;之前的研究表明,在化学机械抛光过程中,摩擦会引起材料的转移,在研究中,更进一步地考察了修整和抛光过程中材料转移的效应;与尼龙和聚碳酸酯相比,聚氨酯的化学、材料和摩擦学性能更为稳定。这使得聚氨酯成为化学机械抛光中较独特的材料。 | G. Xu P. Severs R. Dinsmore S. Meurer H. Liang 朱丽娜(译) 康嘉杰(译) 王海斗(校) | 2008 | 中国表面工程2008，21，3： | 5 |
| 12 | 生态文明建设若干战略研究显示文摘为实现我国从'工业文明'到'生态文明'的转变,2013年中国工程院联合国家开发银行股份有限公司和清华大学开展了'生态文明建设若干战略问题研究'重大咨询研究项目。研究从战略层面探索生态文明建设的三大支柱(资源节约、生态安全和环境保护)如何与新型工业化、城镇化、农业现代化相融合等重大战略问题。研究提出了国土生态安全与水土资源配置格局、生态文明建设中的能源可持续发展战略、生态保护和建设战略、环境保护战略、新型工业化战略、新型城镇化战略、农业现代化战略、绿色消费与文化教育战略、绿色交通运输战略;提出了'十三五'时期生态文明建设目标与重点任务以及生态文明建设政策保障,为国家加快推进生态文明建设提供决策支撑。 | The Comprehensive Research Group for Research on Several Strategic Issues on Eco-Civilization Construction | 2015 | 中国工程科学2015，17，8： | 4 |
| 13 | Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME显示文摘AIM To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadecapeptide BPC 157, which was in trials for ulcerative colitis and currently for multiple sclerosis, in rats with esophagocutaneous fistulas. Previously, BPC 157 therapies have promoted the healing of intestinal anastomosis and fistulas, and esophagitis and gastric lesions, along with rescued sphincter function. Additionally, BPC 157 particularly interacts with the NOsystem. In the 4 d after esophagogastric anastomosis creation, rats received medication(/kg intraperitoneallyonce daily: BPC 157(10 μg, 10 ng), L-NAME(5 mg), or L-arginine(100 mg) alone and/or combined or BPC 157(10 μg, 10 ng) in drinking water). For rats underwent esophagogastric anastomosis, daily assessment included progressive stomach damage(sum of the longest diameters, mm), esophagitis(scored 0-5), weak anastomosis(m L H2 O before leak), low pressure in esophagus at anastomosis and in the pyloric sphincter(cm H2O), progressive weight loss(g) and mortality. Immediate effect assessed blood vessels disappearance(scored 0-5) at the stomach surface immediately after anastomosis creation. RESULTS BPC 157(all regimens) fully counteracted the perilous disease course from the very beginning(i.e., with the BPC 157 bath, blood vessels remained present at the gastric surface after anastomosis creation) and eliminated mortality. Additionally, BPC 157 treatment in combination with L-NAME nullified any effect of L-NAME that otherwise intensified the regular course. Consistently, with worsening(with L-NAME administration) and amelioration(with L-arginine), either L-arginine amelioration prevails(attenuated esophageal and gastric lesions) or they counteract each other(L-NAME + L-arginine); with the addition of BPC 157(L-NAME + L-arginine + BPC 157), there was a marked beneficial effect. BPC 157 treatment for esophagogastric anastomosis, along with NOS-blocker L-NAME and/or NOS substrate L-arginine, demonstrated an innate NO-system disability(as observed with L-arginine effectiveness). BPC 157 distinctively affected corresponding events: worsening(obtained with L-NAME administration that was counteracted); or amelioration(L-arginine + BPC 157-rats correspond to BPC 157-rats).CONCLUSION Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. | Zeljko Djakovic Ivka Djakovic Vedran Cesarec Goran Madzarac Tomislav Becejac Goran Zukanovic Domagoj Drmic Lovorka Batelja Anita Zenko Sever Danijela Kolenc Alen Pajtak Nikica Knez Mladen Japjec Kresimir Luetic Dinko Stancic-Rokotov Sven Seiwerth Predrag Sikiric | 2016 | World Journal of Gastroenterology2016，22，41： | 3 |
| 14 | Characteristics of climate change in the “significant impact zone” affected by aerosols over eastern China in warm seasons显示文摘Through analysis of the distribution pattern and changing characteristics of atmospheric aerosols over the East Asia region during warm seasons in recent 20 a and beyond as well as their possible interac- tive relationship with a variety of meteorological elements, it is found that the high-value zone of aerosol optical depth derived from the Total Ozone Mapping Spectrometer (TOMS), its significant negative correlation zones in terms of sunshine duration (SD) and surface air temperature (SAT) and its significant positive correlation zones with low-level cloud amount (LCC) are co-located in the South China region during warm periods. Based on this finding, the region is referred to as a 'significant impact zone' (SI zone) affected by aerosols. Then, a comparative analysis is made on variation differ- ences of observed SAT, SD and LCC, etc. in different regions. It is also found that the LCC is increased and the SD is decreased within the 'SI zone' over eastern China during the warm season. These characteristics are more evident than those beyond the zone, while the warming trend within the zone is evidently weaker than that outside it. Studies show that since recent 20 a, under the influence of aerosols, the LCC tend to increase substantially with a clear decrease of SD and an unnoticeable warming trend within the 'SI zone'. Comparing with the climate change beyond the zone, the difference is significant. Therefore, the effects of atmospheric aerosols on climate is possibly one of the contri- butions to the difference of climate change existed between the southern and northern parts of the Eastern China during a warm season. | SHI XiaoHui1, XU XiangDe1, XIE LiAn2 1 State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China 2 Department of Marine, Earth and Atmospheric Sciences, North Carolina State University, Raleigh NC27695-8208, USA | 2008 | Science China Earth Sciences2008，51，5： | 2 |
| 15 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 16 | Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME显示文摘AIM To counteract/reveal celecoxib-induced toxicity and NO system involvement. METHODS Celecoxib(1 g/kg b.w. ip) was combined with therapy with stable gastric pentadecapeptide BPC 157(known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg ip) and L-arginine(100 mg/kg ip), as well as NOS blockade [N(G)-nitro-L-arginine methyl ester(L-NAME)](5 mg/kg ip) given alone and/or combined immediately after celecoxib. Gastrointestinal, liver, and brain lesions and liver enzyme serum values in rats were assessed at 24 h and 48 h thereafter. RESULTS This high-dose celecoxib administration, as a result of NO system dysfunction, led to gastric, liver, and brain lesions and increased liver enzyme serum values. The L-NAME-induced aggravation of the lesions was notable for gastric lesions, while in liver and brain lesions the beneficial effect of L-arginine was blunted. L-arginine counteracted gastric, liver and brain lesions. These findings support the NO system mechanism(s), both NO system agonization(L-arginine) and NO system antagonization(L-NAME), that on the whole are behind all of these COX phenomena. An even more complete antagonization was identified with BPC 157(at both 24 h and 48 h). A beneficial effect was evident on all the increasingly negative effects of celecoxib and L-NAME application and in all the BPC 157 groups(L-arginine + BPC 157; L-NAME + BPC 157; L-NAME + L-arginine + BPC 157). Thus, these findings demonstrated that BPC 157 may equally counteract both COX-2 inhibition(counteracting the noxious effects of celecoxib on all lesions) and additional NOS blockade(equally counteracting the noxious effects of celecoxib + L-NAME). CONCLUSION BPC 157 and L-arginine alleviate gastrointestinal, liver and brain lesions, redressing NSAIDs' post-surgery application and NO system involvement. | Domagoj Drmic Danijela Kolenc Spomenko Ilic Lara Bauk Marko Sever Anita Zenko Sever Kresimir Luetic Jelena Suran Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，29： | 2 |
| 17 | Early prediction of anastomotic leakage after colorectal surgery by measuring peritoneal cytokines: Prospective study显示文摘 | Burak U?ra? Murat Giri? Ye?im Erbil Murat G?kp?nar Gamze ??tlak Halim ??sever Alp Bozbora Serdar ?ztezcan | 2007 | International Journal of Surgery2007，，1： | 2 |
| 18 | 阿柏西普治疗雷珠单抗效果不佳的CNV伴难治性色素上皮脱离的疗效(英文)显示文摘目的:评估雷珠单抗反应欠佳患者治疗早期转为阿柏西普治疗疗效。方法:该研究包括38例湿性年龄相关性黄斑变性(W-AMD)患者。18例反应欠佳患者改用玻璃体内阿柏西普(IVA)每月3次疗法,其余20例反应欠佳患者持续进行玻璃体内雷珠单抗(IVR)治疗,每月增加3次使用。所有改变均行荧光素血管造影术(FA)和光学相干断层扫描成像术(OCT)评估。结果:患者术前平均视力(VA)和黄斑中心厚度(CMT)分别为0.84±0.47 logM AR和360±84μm。经过6次IVR或3次IVR联合3次IVA治疗1mo后,两组患者视力分别为1.1±0.14(P=0.11)logM AR和0.48±0.37(P=0.019)logM AR,黄斑中心厚度分别为300±79μm(P=0.002)和271±51μm(P=0.002)。结论:对于雷珠单抗治疗反应欠佳患者,减少重复性治疗早期转为使用阿柏西普疗法对于视力康复是更好的选择。 | Sever Ozkan Horozoglu Fatih | 2017 | 国际眼科杂志2017，17，10： | 2 |
| 19 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 20 | The anglo-scandinavian cardiac outcomes trial lipid lowering arm: extended observations 2 years after trial closure显示文摘 | Sever PS Poulter NR Dahlof B | 2008 | Eur Heart J2008，29，4： | 1 |
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