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| 1 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 2 | Pelvic floor muscle injuries 6 weeks post partum—an intra‐ and inter‐rater study显示文摘 | Jette St?r‐Jensen Franziska Siafarikas Gunvor Hilde Ingeborg H. Br?kken Kari B? Marie Ellstr?m Engh | 2013 | Neurourol Urodyn2013，，7： | 1 |
| 3 | Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso显示文摘 | Peter E. Meissner Germain Mandi Frank P. Mockenhaupt Steffen Witte Boubacar Coulibaly Ulrich Mansmann Claudia Frey Heiko Merkle Juergen Burhenne Ingeborg Walter-Sack Olaf Müller | 2007 | Acta Tropica2007，，1： | 1 |
| 4 | Hematopoietic NF-kappaB1 deficiency resuhs in small atheroselerotic lesions with an inflammatory phenotype 显示文摘 | Kanters E Gijbels M J Ingeborg van der Made | 2004 | Blood2004，103，3： | 1 |
| 5 | The impact of bilateral sagittal split osteotomy on mandibular width and morphology 显示文摘 | Ingeborg M Watzke 1M Heinrich A | 2002 | J Oral Maxillofac Surg2002，60，5： | 1 |
| 6 | De- tection of noroviruses in shellfish in the Netherlands显示文摘 | INGEBORG L A JEROEN J H C NATHALIE A J M | 2006 | Interna- tional Journal of Food Microbiology2006，108，： | 1 |
| 7 | Supplemental Calcium Attenuates the Colitis-Related Increase in Diarrhea, Intestinal Permeability, and Extracellular Matrix Breakdown in HLA-B27 Transgenic Rats1-3显示文摘 | Schepens Marloes A A Schonewille Arjan J Vink Carolien van Schothorst Evert M Kramer Evelien Hendriks Thijs Brummer Robert-Jan Keijer Jaap van der Meer Roelof Bovee-Oudenhoven Ingeborg M J | 2009 | The Journal of Nutrition2009，，8： | 1 |
| 8 | Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions 显示文摘 | Michael L Uli B Ingeborg M | 2008 | Critical Care2008，12，6： | 1 |
| 9 | Effectiveness of Midodrine treatment in patients with recurrent vasovagal syncope not responding to non-pharmacological treatment(STAND-trial)显示文摘 | Romme J J C M Dijk N V Ingeborg K G | | 0，，11： | 1 |
| 10 | Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions 显示文摘 | Michael Uli C Ingeborg M | 2008 | Crit Care2008，12，6： | 1 |
| 11 | The impact of bilateral sagittal split osteotomy on mandibular width and morphology显示文摘 | Ingeborg M Watzke 1M Heinrich A | | 0，，05： | 1 |
| 12 | Human papillomavirus16 E6 polymorphisms in cervical lesions from different Europe-an populations and their correlation with human leukocyte anti-gen class II haplotypes 显示文摘 | Ingeborg Z Ruth T Joannis M | 2001 | International Journal of Cancer2001，94，： | 1 |
| 13 | Nicotinic acid adenine dinucleotide phosphate(NAADP+) is an essential regulator of T-lymphocyte Ca2+-signaling显示文摘 | Ingeborg B Barry V L P Georg W M | 2000 | J Cell Biol2000，150，： | 1 |
| 14 | In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients显示文摘 | Ingo Müller Birgit Kustermann-Kuhn Christina Holzwarth Gesa Isensee Martin Vaegler Klaus Harzer Ingeborg Kr?geloh-Mann Rupert Handgretinger Gernot Bruchelt | 2006 | Experimental Hematology2006，，10： | 1 |
| 15 | The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome显示文摘 | Ingeborg Heymann-M?nnikes Rudolf Arnold Irmela Florin Christoph Herda Siebke Melfsen Hubert M?nnikes | 2000 | The American Journal of Gastroenterology2000，，4： | 1 |
| 16 | Towards a multiscale model of colorectal cancer显示文摘Colorectal cancer (CRC) is one of the best characterised cancers, with extensive data documenting the sequential gene mutations that underlie its development. Complementary datasets are also being generated describing changes in protein and RNA expression, tumour biology and clinical outcome. Both the quantity and the variety of information are inexorably increasing and there is now an accompanying need to integrate these highly disparate datasets. In this article we aim to explain why we believe that mathematical modelling represents a natural tool or language with which to integrate these data and, in so doing, to provide insight into CRC. | Ingeborg MM van Leeuwen Carina M Edwards Mohammad Ilyas Helen M Byrne | 2007 | World Journal of Gastroenterology2007，13，9： | 1 |
| 17 | Dietary Fructooligosaccharides Affect Intestinal Barrier Function in Healthy Men 显示文摘 | Sandra J M Ten Bruggencate Ingeborg M J | 2006 | Journal of Nutrition2006，，136： | 1 |
| 18 | EZH2 expression is as- sociated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast显示文摘 | Ingeborg M Bachmann OJ Halvorsen KC | 2006 | J Clin Oncol2006，24，2： | 1 |
| 19 | Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study显示文摘 | Andreas Stang Hermann Pohlabeln Klaus M. Müller Ingeborg Jahn Klaus Giersiepen Karl-Heinz J?ckel | 2006 | Lung Cancer2006，，1： | 1 |
| 20 | Relationship between glycolysis and exopolysaccharides biosynthesis in lactococcus lactis 显示文摘 | ANA RAMOS INGEBORG C B WILEM M D V | 2001 | Applied and environmental microbiology2001，，： | 1 |
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