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| 1 | Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species显示文摘Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich flora.In the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune habitats.This invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic char-acteristics.The aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive spe-cies.We addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode level.Methods In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought resistance.Important Findings The results support our initial hypothesis:although A.longifolia clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native species.Natives relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water loss.We corroborate that woody native species(i)have a conservative water-saving strategy and minor seasonal variations relative to invasive species,(ii)use enriched water sources during drought periods,indicating different water sources and root systems com-paring with invasive species and(iii)present drought leaf morpho-functional adaptations related with limiting water loss.Comparing the physiological performance of invasive and native species can offer causal explanations for the relative success of alien plant invasions on sand dunes ecosystems. | Cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia Cristina Máguas | 2018 | Journal of Plant Ecology2018，11，1： | 4 |
| 2 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 3 | Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification显示文摘● AIM: To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema(CME) after phacoemulsification.● METHODS: Group sequential observational comparative study. After phacoemulsification, patients received two months for topical treatment of either diclofenac sodium, bromfenac or nepafenac. All patients received concomitant topical tobramycin 0.3% and topical prednisolone 1%. We measured CME using optical coherence tomography(OCT) central foveal thickness, macular thickness and total macular volume.● RESULTS: We enrolled 243 patients from January to June 2015, and 35% received diclofenac, 32.9% bromfenac and 32.1% nepafenac. When we compared pre-operative to three weeks to two months, bromfenac was more effective in reducing foveal volume(21.3 and 35.4 mm3, respectively), compared with the diclofenac(1.3 and 11.5 mm3, respectively), and the nepafenac group, became more edematous 6.4 and 5.3, respectively. Totally 133 patients completed the post-surgical satisfaction questionnaire. Patients complained of eye stickiness in 13.8% whom we gave nepafenac, versus 10.3% whom we gave diclofenac sodium, and in 0 whom we gave bromfenac.● CONCLUSION: Bromfenac is the best tolerated and is more effective than diclofenac and nepafenac in reducing CME after phacoemulsification. | Ana Maria Chinchurreta Capote Mercedes Lorenzo Soto Francisco Rivas Ruiz Enrique Caso Peláez Alicia Garcia Vazquez Group OftaCosta Antonio Ramos Suárez | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 2 |
| 4 | Dynamics of Droplets of Biological Fluids on Smooth Superhydrophobic Surfaces under Electrostatic Actuation显示文摘 | Ana Sofia Moita Catarina Laurencia Joana Anastacio Ramos Duarte Miguel Franca Prazeres Antonio Luis Nobre Moreira | 2016 | Journal of Bionic Engineering2016，13，2： | 2 |
| 5 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 6 | Osteopenia: a bone disorder associated with diabetes mellitus显示文摘 | Valéria M.G. Duarte Ana M.O. Ramos Luciana A. Rezende Ulisvaldo B.O. Macedo José Brand?o-Neto Maria G. Almeida Adriana A. Rezende | 2005 | Journal of Bone and Mineral Metabolism2005，，1： | 1 |
| 7 | Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress显示文摘 | María Vicario Mar Guilarte Carmen Alonso Pinchang Yang Cristina Martínez Laura Ramos Beatriz Lobo Ana González Meritxell Guilà Marc Pigrau Esteban Saperas Fernando Azpiroz Javier Santos | 2010 | Brain Behavior and Immunity2010，，7： | 1 |
| 8 | Carment Tejedo显示文摘 | Pilar Sancho Ana Piancho Pedro Ramos | 2004 | Waste Management2004，，24： | 1 |
| 9 | Progress in the development of animal models of acute kidney injury and its impact on drug discovery显示文摘 | Ana B Sanz Marí a Dolores Sanchez-Ni? o Catalina Martí n-Cleary Alberto Ortiz Adriá n M Ramos | 2013 | Expert Opinion on Drug Discovery2013，，7： | 1 |
| 10 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 11 | Synergistic action of azoreductase and laccase leads to maximal decolourization and detoxification of model dye-containing wastewaters显示文摘 | Sónia Mendes Ana Farinha Christian G. Ramos Jorge H. Leit?o Cristina A. Viegas Lígia O. Martins | 2011 | Bioresource Technology2011，，21： | 1 |
| 12 | Quality mainte- nance improvement of Pleurotus ostreatus mushroom by modified atmos- phere packaging 显示文摘 | Maria Sapata Ana Ramos Armando Ferreira | 2009 | Acta Scientiarum Polonorum2009，8，2： | 1 |
| 13 | BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)显示文摘 | Carlos Santamaría María C. Chillón Ramón García-Sanz Cristina Pérez María D. Caballero María V. Mateos Fernando Ramos Alfonso García Coca José M. Alonso Pilar Giraldo Teresa Bernal José A. Queizán Juan N. Rodríguez Noemí Puig Ana Balanzategui María E. Sar | 2010 | Annals of Hematology2010，，5： | 1 |
| 14 | Kinetic evaluation of the pyrolysis of polyethylene waste显示文摘 | Paula A Costa Filomena J Pinto Ana M Ramos | 2007 | Energy&Fuels2007，21，5： | 1 |
| 15 | Stability to gastrointes-tinal enzymes and structure-activity relationship of [be-ta]-casein-peptides with antihypertensive properties显示文摘 | Ana Q Contreras MM Ramos M | | 0，，： | 1 |
| 16 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 17 | Impacto da idade no tratamento e resultados após enfarte agudo do miocárdio em particular nos muito idosos显示文摘 | Ana Teresa Timóteo Ruben Ramos Alexandra Toste Ana Lousinha José Alberto Oliveira Maria Lurdes Ferreira Rui Cruz Ferreira | 2011 | Revista Portuguesa de Cardiologia2011，，12： | 1 |
| 18 | Green synthesis of colloidal silver nanoparticles using natural rubber latex extracted from Hevea brasiliensis显示文摘 | Eder José Guidelli Ana Paula Ramos Maria Elisabete D. Zaniquelli Oswaldo Baffa | 2011 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2011，，1： | 1 |
| 19 | In vivo growth inhibition of sarcoma 180 by latex proteins from Calotropis procera显示文摘 | Jefferson S. Oliveira Letícia V. Costa-Lotufo Daniel P. Bezerra Nylane M. N. Alencar José Delano B. Marinho-Filho Ingrid Samantha T. Figueiredo Manoel O. Moraes Claudia Pessoa Ana Paula N. N. Alves Márcio V. Ramos | 2010 | Naunyn - Schmiedeberg’s Archives of Pharmacology2010，，2： | 1 |
| 20 | Combining heuristic procedures and simulation models for balancing a PC camera assembly line显示文摘 | Ana R Mendes Ana L Ramos Ana S Simaria | 2005 | Computers & Industrial Engineering2005，49，3： | 1 |
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