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| 1 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 2 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 3 | Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions显示文摘AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) execution.METHODS:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was made.The following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for comparison.RESULTS:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both explorations.Three anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both groups.CONCLUSION:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session. | Juan J Vila Marcos Kutz Silvia Goi Miriam Ostiz Edurne Amorena Carlos Prieto Cristina Rodriguez Ignacio Fernández-Urien Francisco J Jiménez | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 4 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 5 | Optimization of sensitivity in long period fiber gratings with overlay deposition显示文摘 | Ignacio D V Ignacio R Matias I R | 2005 | Optics Express2005，13，1： | 1 |
| 6 | New method to assess barley nitrogen nutrition status based on image colour analysis Comparison with SPAD-502显示文摘 | MIGUEL P RUBEN O IGNACIO I | 2009 | Computers and Electronics in Agriculture2009，65，2： | 1 |
| 7 | A comparative study of high-accuracy frequency estimation methods显示文摘 | Ignacio S Carlos P Jesus I | 2000 | Mechanical Systems and Signal Processing2000，14，5： | 1 |
| 8 | Tadalafil Enhances the Inhibitory Effects of Tamsulosin on Neurogenic Contractions of Human Prostate and Bladder Neck显示文摘 | Javier Angulo Pedro Cuevas Argentina Fernández José M. La Fuente Antonio Allona Ignacio Moncada I?igo Sáenz de Tejada | 2012 | The Journal of Sexual Medicine2012，，9： | 1 |
| 9 | The design of rainfall networks in time and space显示文摘 | IGNACIO R I JOSE M M | 1974 | Water Resources Research1974，10，： | 1 |
| 10 | The new LNG-releasing IUS: a new opportunity to reduce the burden of unintended pregnancy显示文摘 | Ignacio Cristobal José-Luis Neyro I?aki Lete | 2015 | European Journal of Obstetrics and Gynecology2015，，： | 1 |
| 11 | First peptide vaccine providing protection against viral infection in the target animal:studies of canine parvovirus in dogs显示文摘 | JAN P M LANGEVELD I J IGNACIO C | 1994 | J Virol1994，68，7： | 1 |
| 12 | Partial liver volume radioembolization induces hypertrophy in the spared hemiliver and no major signs of portal hypertension显示文摘 | Nerea Fernández‐Ros Nuno Silva Jose Ignacio Bilbao Mercedes I?arrairaegui Alberto Benito Delia D’Avola Macarena Rodriguez Fernando Rotellar Fernando Pardo Bruno Sangro | 2014 | HPB2014，，3： | 1 |
| 13 | Nannochloropsis (Eustigmatophyceae) as source of commercially valuable pigment显示文摘 | Lubian L M Olimpio Montero Ignacio Moreno-Garrido Huertas I E Cristina Sobrino Manuel Gonzalez-del Valle Griselda Pares | 2000 | Journal of AppliedPhycology2000，12，： | 1 |
| 14 | Spatial and temporal trends of PCBs (polychlorinated biphenyls) in mussel from Galician coast (1998 - 2008) 显示文摘 | CARRO N GARCIA I IGNACIO M | 2010 | Environment International2010，36，8： | 1 |
| 15 | Structural gender differences in perceived social support 显示文摘 | Mafia PM Ignacio I Juan MB | 2003 | Pers Individ Differ2003，35，8： | 1 |
| 16 | Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification显示文摘 | Travis William D Brambilla Elisabeth Noguchi Masayuki Nicholson Andrew G Geisinger Kim Yatabe Yasushi Ishikawa Yuichi Wistuba Ignacio Flieder Douglas B Franklin Wilbur Gazdar Adi Hasleton Philip S Henderson Douglas W Kerr Keith M Petersen I | 2013 | Archives of Pathology & Laboratory Medicine2013，，5： | 1 |
| 17 | 前列腺癌根治术后终末期勃起功能障碍和压力性尿失禁的管理,通过单一反式阴囊切口做同步双植入:手术技术和结果显示文摘前列腺癌根治术(RP)后压力性尿失禁(SUI)和终末期勃起功能障碍(ED),可降低生活患者的生存质量(QoL)。我们描述一个手术技术,有关经阴囊切口人工尿道括约肌(AUS)和充气阴茎假体(IPP)的同步双植入。有RP后的中度至重度SUI(〉每天3片尿垫)和终末期ED的患者,被选择做双植入。做一个阴囊上部横切口,随后分离尿道球部和植入AUS。通过同一切口,暴露海绵体,植入IPP。其次在腹膜外植入贮液囊,在阴囊内植入泵。短期,术中和术后并发症;尿控状态和勃起功能; 病人满意度和生活质量被记录下来。共有32例患者进行双植入术。早期AUS相关的并发症有:AUS贮液囊移位及尿道侵蚀。发生一例远端海绵体挤压。无假体感染的发生。超过96%的患者社会功能良好,排尿(每日≤1尿垫)和 〉 95%有足够勃起来性交。该研究的局限性是患者数量少,缺少采用会阴途径安置AUS的对照,只有12个月随
访。使用单一阴囊切口IPP和AUS双重植入技术,对RP后SUI和ED患者,是一种安全和有效的选择。更大患者数量的进一步的研究是必要的。 | Juan I Martinez-Salamanca Estefania Linares Espinos Ignacio Moncada Luis Del Portillo Joaquin Carballido | 2015 | Asian Journal of Andrology2015，17，5： | 1 |
| 18 | Development of alcoholic and malolactic fermentations in highly acidic and phenolic apple musts显示文摘 | Gloria del Campo I?aki Berregi José Ignacio Santos Maite Due?as Ana Irastorza | 2007 | Bioresource Technology2007，，8： | 1 |
| 19 | Ammonium oxidation kinetics in the presence of nitrification inhibitor DCD andDMPP at various temperatures显示文摘 | Ignacio I Muro J Azp ilikueta M | 2003 | Australian Journal of Soil Research2003，41，： | 1 |
| 20 | AC and DC technology in microgrids: A review显示文摘 | Estefanía Planas Jon Andreu José Ignacio Gárate I?igo Martínez de Alegría Edorta Ibarra | 2014 | Renewable and Sustainable Energy Reviews2014，，： | 1 |
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