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| 1 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 2 | FDI and economic growth: the role of local financial markets显示文摘 | Laura Alfaro Areendam Chanda Sebnem Kalemli-Ozcan Selin Sayek | 2003 | Journal of International Economics2003，，1： | 6 |
| 3 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 4 | Validating a dust production model by field experiment in Mu Us Desert, China显示文摘Field experiments of dust production have been seldom performed in Chinese deserts that are identified as one of main dust sources in the world, and such an experiment to validate a dust production model (DPM) has not been made in China until now. Saltation flux, dust emission flux, surface features and meteorological parameters (U*, Z0, Ri, etc.) were investigated in Mu Us Desert of China to verify the DPM model and accumulate dust emission data during the spring of 2002. It indicates that observed saltation fluxes from 0.07 to 8.00 g·m?1·s?1 are in good agreement with the ones predicted by the DPM model when the constant of the saltation flux equation is tuned to about 2.61, which corresponds to wind fric- tion velocities from 0.26 to 0.35 m·s?1. Unfortunately, during three local dust emission events, the observed dust fluxes are from 1 to 3 μg· m?2· s?1, lower than the modeled ones, implying that the model needs to be improved further under lower wind velocity. In comparison with data from a sandy soil with physical crust and a loam soil, saltation fluxes of the loose sandy soil in Mu Us Desert are obviously higher, which suggests that deserts and sandy land with desertification are major dust sources in northern China. | MEI Fanmin J. Rajot S. Alfaro L. Gomes ZHANG Xiaoye WANG Tao | 2006 | Chinese Science Bulletin2006，51，7： | 3 |
| 5 | 显示文摘 | Sola A Alfaro V Vinas JL | 2004 | Pflugers Arch2004，447，4： | 1 |
| 6 | Obstetrical hysterectomy, Evolution and change显示文摘 | URIBE ELIAS R ACOSTA ALFARO M A | 1996 | Ginecol Obster Mer1996，64，： | 1 |
| 7 | Genetic relations- hips among Orobanche pecies as revealed by PAPD analysis显示文摘 | Roman B Alfaro C Torres AM | 2003 | Ann Bot(Lond)2003，91，6： | 1 |
| 8 | Clear lens extraction and implantation of negative-power posterior chamber intraocular lenses to correct extreme myopia显示文摘 | Jimenez Alfaro I Miguelez S Bueno JL | | 0，，： | 1 |
| 9 | Preoperative iden- tification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement显示文摘 | ROCHA E ALFARO M J PARAMO J A | 2008 | Thromb Haemost2008，59，： | 1 |
| 10 | Theoretical framework for assessment of risks posed to Canadian forests by invasive insect species显示文摘 | Fuentealba A Alfaro R Bauce | 2013 | Forest Ecology and Management2013，302，： | 1 |
| 11 | Interface automata显示文摘 | Alfaro Ld Henzinger T A | | 0，，05： | 1 |
| 12 | Robust tuning of 2 DoF five-parameter PID controllers for inverse response controlled processes 显示文摘 | Alfaro V M Vilanova R | 2013 | Journal of Process Control2013，23，： | 1 |
| 13 | Performancemeasurement system for business processes显示文摘 | ALFARO J ORTIZ A POLER R | 2007 | ProductionPlanning and Control2007，18，8： | 1 |
| 14 | Contrast sensitivity after posterior chamber pbaloc intraoc- ular lens implantation for high myopia 显示文摘 | JIMENEZ ALFARO I GOMEZ TEKKERIA G BUENO JL PUY P | 2001 | J Refract Surg2001，17，： | 1 |
| 15 | Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8显示文摘 | Feijoo E Alfaro C Mazzolini G | 2005 | Int J Cancer2005，116，2： | 1 |
| 16 | Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons 显示文摘 | Cerpa W Godoy J A Alfaro I | 2008 | J Biol Chem2008，283，9： | 1 |
| 17 | Brucellar spondylitis:review of35 cases and literature survey显示文摘 | Solera J Lozano E Alfaro EM | 1999 | Clin Infect Dis1999，29，4： | 1 |
| 18 | Dendritic cells take up and present antigens from viable and apoptotic polymor- phonuclear leukocytes显示文摘 | Alfaro C Suarez N Ofiate C | 2011 | PLoS ONE2011，6，29： | 1 |
| 19 | Meshless methods with application to metal forming显示文摘 | Alfaro I | 2006 | Computer Methods in Applied Mechanics and Engineering2006，，195： | 1 |
| 20 | A boosting approach for understanding out-of-control signals in multivariate control charts 显示文摘 | Alfaro E Alfaro J G:mez M | 2009 | International Journal of Production Research2009，47，24： | 1 |
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