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| 1 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 2 | Colorectal cancer and 18FDG-PET/CT:What about adding the T to the N parameter in loco-regional staging?显示文摘AIM:To evaluate whether FDG-positron emission tomography(PET)/computed tomography(CT)may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS:Thirty four consecutive patients(20 men and 14 women;mean age:63 years)with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages(≤T2,T3,T4).Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS:Thirty five/37(94.6%)adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%(95%CI:87%-100%).All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION:Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer. | Pier Paolo Mainenti Delfina Iodice Sabrina Segreto Giovanni Storto Mario Magliulo Giovanni Domenico De Palma Marco Salvatore Leonardo Pace | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 3 | Vitamin D Status and Mortality Risk in CKD: A Meta-analysis of Prospective Studies显示文摘 | Stefan Pilz Simona Iodice Armin Zittermann William B. Grant Sara Gandini | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 4 | Safety and effectiveness of sorafenib in patients with hepatocellular carcinoma in clinical practice显示文摘 | Giovan Giuseppe Di Costanzo Raffaella Tortora Luca Iodice Alfonso Galeota Lanza Filippo Lampasi Maria Teresa Tartaglione Francesco Paolo Picciotto Silvana Mattera Massimo De Luca | 2012 | Digestive and Liver Disease2012，，9： | 2 |
| 5 | Increased hepatitis C viral load and reactivation of liver disease in HCV RNA-positive patients with onco-haematological disease undergoing chemotherapy显示文摘 | Nicola Coppola Mariantonietta Pisaturo Salvatore Guastafierro Gilda Tonziello Antonello Sica Valentina Iodice Caterina Sagnelli Maria Giovanna Ferrara Evangelista Sagnelli | 2011 | Digestive and Liver Disease2011，，1： | 2 |
| 6 | Air-Filled vs Water-Filled Intragastric Balloon: a Prospective Randomized Study显示文摘 | Cristiano Giardiello Alessandro Borrelli Eufemia Silvestri Valentina Antognozzi Giuseppe Iodice Michele Lorenzo | 2012 | Obesity Surgery2012，，12： | 1 |
| 7 | Non-erythropoietic eryth-ropoietin derivatives protect from light-induced and genetic photore-ceptor degeneration显示文摘 | Colella P Iodice C Di Vicino U | 2011 | Hum Mol Genet2011，20，11： | 1 |
| 8 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，3： | 1 |
| 9 | Time efficiency of self-ligating vs conventional brackets in orthodontics: Effect of appliances and ligating systems显示文摘 | Paduano S Cioffi I Iodice G | 2008 | Prog Orthod2008，9，2： | 1 |
| 10 | Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies 显示文摘 | PILZ S IODICE S ZITI'ERMANN A | 2011 | Am J Kidney Dis2011，58，3： | 1 |
| 11 | Smoking and colorectal canc- er: a meta-analysis 显示文摘 | Botteri E Iodice S Bagnardi V | 2008 | JAMA2008，300，23： | 1 |
| 12 | Time efficiency of selfligating vs conventional brackets in orthodontics:Effect of appliances and ligating systems显示文摘 | Paduano S Cioffi I Iodice G | 2008 | Prog Orthod2008，9，2： | 1 |
| 13 | Autopsy confirmed multiple system atrophy eases: Mayo experience and role of auto- nomic function tests显示文摘 | IODICE V LIPP A AHLSKOG J E | 2012 | J Neurol Neurosurg Psychiatry2012，83，4： | 1 |
| 14 | Smoking and colorectal cancer:a meta-analysis 显示文摘 | Botteri E Iodice S Bagnardi V | 2008 | JAMA2008，300，23： | 1 |
| 15 | Single-step treatment of gallbladder and bile duct stones:a combined endoscopic-laparoscopic technique显示文摘 | Iodice G Giardiello C Francica G | 2001 | Gastrointest Endosc2001，53，3： | 1 |
| 16 | Effetti ventilatoriedemogasanalitical della somm in istrazione acute della doxo-fyllina in soggetti con BPCO显示文摘 | Iodice F De-Michele F Sena A | 2001 | Respiratory Medicine2001，8，6： | 1 |
| 17 | Vitamin D status and mortality risk in CKD: a meta- analysis of prospeetive studies 显示文摘 | Pilz S Iodice S Zittermann A | 2011 | Am J Kidney Dis2011，58，3： | 1 |
| 18 | Efficient simulation of airborne SAR raw data of extended scenes显示文摘 | FRANCE S G IODICE A PERNA S | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，10： | 1 |
| 19 | High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma显示文摘 | Franca Falzetti Mauro Ianni Stelvio Ballanti Giuseppe Iodice Antonia Reale Olivia Minelli Gabriella Serio Massimo Martelli Franco Dammacco Angelo Vacca Roberto Ria | 2012 | Clinical and Experimental Medicine2012，，3： | 1 |
| 20 | Efficient simulation of hybrid stripmap spotlight SAR raw signals from extended scenes 显示文摘 | FRANCESCHETTI G GUIDA R IODICE A | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，11： | 1 |
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