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| 1 | Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy显示文摘AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. | Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi | 2013 | World Journal of Gastroenterology2013，19，2： | 12 |
| 2 | Diagnostic ability of multi-detector spiral computed tomography for pathological lymph node metastasis of advanced gastric cancer显示文摘BACKGROUND The reliability of preoperative nodal diagnosis of advanced gastric cancer by multi-detector spiral computed tomography(MDCT)is still unclear.AIM To examine the diagnostic ability of MDCT more precisely by using data on intranodal pathological metastatic patterns.METHODS A total of 108 patients with advanced gastric cancer who underwent MDCT and curative gastrectomy at Kanazawa Medical University Hospital were enrolled in this study.The nodal sizes measured on computed tomography(CT)images were compared with the pathology results.A receiver-operating characteristic curve was constructed,from which the critical value(CV)was calculated by using the data of the first 69 patients retrospectively.By using the CV,sensitivity and specificity were calculated with prospectively collected data from 39 consecutive patients.This enabled a more precise one-to-one correspondence of lymph nodes between CT and pathological examination by using the size data of lymph node mapping.The intranodal pathological metastatic patterns were classified into the following four types:Small nodular,peripheral,large nodular,and diffuse.RESULTS Although all the cases were clinically suspected as having metastasis,81 had lymph node metastasis and 27 had no metastasis.The number of dissected,detected on CT,and metastatic nodes were,4241,897,and 801,respectively.The CV obtained from the receiver-operating characteristic was 7.6 mm for the long axis.The sensitivity was 91.4%and the specificity was 47.3%in the prospective phase.The large nodular and diffuse metastases were easy to diagnose becausemetastatic nodes with a large axis often exhibit these forms.CONCLUSION The ability of MDCT to contribute to a nodal diagnosis of advanced gastric cancer was examined prospectively with precise size data from node mapping,using a CV of 7.6 mm for the long axis that was calculated from the retrospectively collected data.The sensitivity was as high as 91%,and would be improved when referring to the enhanced patterns.However,its specificity was as low as 47%,because most of metastatic nodes in gastric cancer being small in size.The small nodular or peripheral type metastatic nodes were often small and considered difficult to diagnose. | Zhi-Yong Jiang Shinichi Kinami Naohiko Nakamura Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka | 2020 | World Journal of Gastrointestinal Oncology2020，12，4： | 5 |
| 3 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 4 | Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs显示文摘 | Akihiro Hosomi Makoto Arita Yuji Sato Chikako Kiyose Tadahiko Ueda Osamu Igarashi Hiroyuki Arai Keizo Inoue | 1997 | FEBS Letters1997，，1： | 3 |
| 5 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 6 | Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples显示文摘 | Keiki Kumano Shunya Arai Masataka Hosoi Kazuki Taoka Naoya Takayama Makoto Otsu Genta Nagae Koki Ueda Kumi Nakazaki Yasuhiko Kamikubo Koji Eto Hiroyuki Aburatani Hiromitsu Nakauchi Mineo Kurokawa | 2012 | Blood2012，，26： | 1 |
| 7 | Distinct isoprenoid origins of cis-and transzeatin biosyntheses in Arabidopsis显示文摘 | HIROYUKI KASAHARA KENTARO TAKEI NANAE UEDA | 2004 | Journal of Biological Chemistry2004，279，14： | 1 |
| 8 | α‐fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C显示文摘 | Yasuhiro Asahina Kaoru Tsuchiya Takashi Nishimura Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Takanori Hosokawa Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Masayuki Kurosaki Nobuyuki Enomoto Mina Nakagawa Sei Kakinuma Mamoru Wat | 2013 | Hepatology2013，，4： | 1 |
| 9 | Fermentative production of L-Leueine with Auxotrophic Mutants of Corynebacteriun glutamicum显示文摘 | Kazumi Araki Hiroyuki Ueda Shigeru Saigusa | 1974 | Agr Biol Chem1974，38，3： | 1 |
| 10 | Correlation between p14 ARF /p16 INK4A expression and HPV infection in uterine cervical cancer显示文摘 | Hiroyuki Kanao Takayuki Enomoto Yutaka Ueda Masami Fujita Ryuichi Nakashima Yuko Ueno Takashi Miyatake Tatsuo Yoshizaki Gregory S Buzard Toshihiro Kimura Kiyoshi Yoshino Yuji Murata | 2004 | Cancer Letters2004，，1： | 1 |
| 11 | Clinicopathological Features of Serrated Adenocarcinoma Defined by Makinen in Dukes’ B Colorectal Carcinoma显示文摘 | Shida Yosuke Fujimori Takahiro Tanaka Hiroyuki Fujimori Yukari Kimura Ryusuke Ueda Hirofumi Ichikawa Kazuhito Tomita Shigeki Nagata Hitoshi Kubota Keiichi Tsubaki Masahiro Kato Hiroyuki Yao Takashi Sugai Tamotsu Sugihara Kenichi Ohkura Yas | 2012 | Pathobiology2012，，4： | 1 |
| 12 | Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d -isomer peptides consisting of Pas and the p53 C-terminus显示文摘 | Yutaka Ueda Fan-Yan Wei Taku-ichiro Hide Hiroyuki Michiue Kentaro Takayama Taku Kaitsuka Hideo Nakamura Keishi Makino Jun-ichi Kuratsu Shiroh Futaki Kazuhito Tomizawa | 2012 | Biomaterials2012，，35： | 1 |
| 13 | The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR显示文摘 | Junko Sugatani Hiroyuki Kojima Akiko Ueda Satoru Kakizaki Kouichi Yoshinari Qi-Hui Gong Ida S. Owens Masahiko Negishi Tatsuya Sueyoshi | 2001 | Hepatology2001，，5： | 1 |
| 14 | Prevention of postoperative complications in skull base surgery for nasal or paranasal sinus carcinoma invading the skull base显示文摘 | Shigeru Nishizawa Naoki Yokota Tetsuo Yokoyama Hiroyuki Mukodaka Takahiro Watanabe Tomoyuki Hoshino Yoshio Ueda | 2001 | Journal of Clinical Neuroscience2001，，4： | 1 |
| 15 | ANTI-INTERLEUKIN 6 (IL-6) RECEPTOR ANTIBODY SUPPRESSES CASTLEMAN’S DISEASE LIKE SYMPTOMS EMERGED IN IL-6 TRANSGENIC MICE显示文摘 | Asao Katsume Hiroyuki Saito Yoshiki Yamada Keigo Yorozu Otoya Ueda Ken-Ichi Akamatsu Norihiro Nishimoto Tadamitsu Kishimoto Kazuyuki Yoshizaki Yoshiyuki Ohsugi | 2002 | Cytokine2002，，6： | 1 |
| 16 | Absence of asymptomatic unruptured renal artery pseudoaneurysm on contrast-enhanced computed tomography after robot-assisted partial nephrectomy without parenchymal renorrhaphy显示文摘Objective:To assess the incidence of asymptomatic unruptured renal artery pseudoaneurysm(RAP)on contrast-enhanced computed tomography(CE-CT)after robot-assisted partial nephrectomy(RAPN)without parenchymal renorrhaphy.Methods:From May 2016 to December 2017,78 patients underwent RAPN for renal tumors.Inner suture was performed in the opened collecting system or renal sinus,whereas parenchymal renorrhaphy was not.For hemostasis,the soft coagulation system was used,and absorbable hemostats were placed on the resection bed.CE-CT was carried out within 7 days after surgery.Data on these patients were prospectively collected.A single radiologist determined the diagnosis of RAP.Results:Median(range)data were as follows:Patient age,65(19-82)years;radiographic tumor size,30(12-95)mm;operating time,166(102-294)min;warm ischemic time,16(7-67)min;and blood loss,15(0-4450)mL.One patient(1.6%)required a perioperative blood transfusion.No patient required conversion to open surgery or nephrectomy.CE-CT was carried out at median 6(3-7)days after surgery.CE-CT showed no RAP development in all 61 patients.Urinary leakage was not observed.One patient had acute cholecystitis,a postoperative complication classified as Clavien-Dindo grade higher than 3,which was treated with cholecystectomy.Positive surgical margin was identified in four patients(6.6%).Conclusion:RAPN using soft coagulation and absorbable hemostats without renorrhaphy appears to be feasible and safe.Our technique could eliminate the risk of RAP. | Yoichiro Tohi Shiori Murata Noriyuki Makita Issei Suzuki Masashi Kubota Yoshio Sugino Koji Inoue Hiroyuki Ueda Mutsushi Kawakita | 2020 | Asian Journal of Urology2020，7，1： | 1 |
| 17 | Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes显示文摘 | Shoichi Ehara Makiko Ueda Takahiko Naruko Kazuo Haze Akira Itoh Masato Otsuka Ryushi Komatsu Toshihiko Matsuo Hiroyuki Itabe Tatsuya Takano Yoshiaki Tsukamoto Minoru Yoshiyama Kazuhide Takeuchi Junichi Yoshikawa Anton E. Becker | 2001 | Circulation: Journal of the American Heart Association2001，，15： | 1 |
| 18 | Efficacy of the fat-dissociation method for nodal harvesting in gastric cancer显示文摘BACKGROUND There is an increased need for accurate staging for gastric cancer treatment.Consequently, it is necessary to carefully examine all dissected lymph nodes for precise staging. Recently, the fat-dissociation method has been developed as a quick and accurate method for harvesting dissected lymph nodes of colorectal cancer cases.AIM To investigate the usefulness of the fat-dissociation method for harvesting dissected lymph nodes of gastric cancer cases.METHODS Fifty-six resected specimens from gastric cancer patients who underwent standard curative gastrectomy and lymph node dissection at our hospital were used. Group 2 lymph nodes were separated from each specimen, and the remaining adipose tissue containing the group 1 lymph nodes was used. Some resected specimens were subjected to the fat-dissociation method. One vial of Imofully~? was dissolved in 50 m L of saline and injected into the tissue. The tissue was incubated for 1 h and the dissolved fat was removed. Subsequently, the nodes were identified, picked up with scissors, and mapped. The number of nodes in each lymphatic compartment and duration of lymph node harvest and mapping were compared.RESULTS The fat-dissociation method was used for 24 samples, while the conventional dissection method was used for 32 samples. The total number of harvested lymph nodes was 45.9 in the fat dissociation group and 44.3 in the control group, and there was no significant difference between the two groups. There were also no significant differences in the number of lymph nodes between the two groups based on a comparison of the lymphatic compartments. However, the total median duration of the fat-dissociation method was 38.2 min, reflecting a reduced duration of approximately 60 min compared to the control group.CONCLUSION Based on our results, the fat-dissociation method is effective in shortening the duration of lymph node harvest in gastric cancer surgery. | Shinichi Kinami Toshio Ohnishi Naohiko Nakamura Zhi Yong Jiang Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka | 2020 | World Journal of Gastrointestinal Surgery2020，12，6： | 1 |
| 19 | The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer显示文摘 | Tetsuya Oguri Hiroyuki Achiwa Hideki Muramatsu Hiroaki Ozasa Shigeki Sato Shigeki Shimizu Hideko Yamazaki Tadaaki Eimoto Ryuzo Ueda | 2007 | Cancer Letters2007，，1： | 1 |
| 20 | A Warning Index Used in Prescreening for Alzheimer’s Disease, Based on Self-Reported Cognitive Deficits and Vascular Risk Factors for Dementia in Elderly Patients with Type 2 Diabetes显示文摘 | Toshioki Matsuzawa Toshihiro Takata Koichi Yokono Hiroo Ueda Kensuke Moriwaki Isao Kamae Katsuya Urakami Takashi Sakurai Hiroyuki Umegaki | 2012 | International Journal of Alzheimer’s Disease2012，，： | 1 |
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