|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surgical techniques and postoperative management to prevent postoperative pancreatic fistula after pancreatic surgery显示文摘Postoperative pancreatic fistula (POPF) is one of the most severe complications after pancreatic surgeries. POPF develops as a consequence of pancreatic juice leakage from a surgically exfoliated surface and/or anastomotic stump, which sometimes cause intraperitoneal abscesses and subsequent lethal hemorrhage. In recent years, various surgical and perioperative attempts have been examined to reduce the incidence of POPF. We reviewed several well-designed studies addressing POPF-related factors, such as reconstruction methods, anastomotic techniques, stent usage, prophylactic intra-abdominal drainage, and somatostatin analogs, after pancreaticoduodenectomy and distal pancreatectomy, and we assessed the current status of POPF. In addition, we also discussed the current status of POPF in minimally invasive surgeries, laparoscopic surgeries, and robotic surgeries. | Hiromichi Kawaida Hiroshi Kono Naohiro Hosomura Hidetake Amemiya Jun Itakura Hideki Fujii Daisuke Ichikawa | 2019 | World Journal of Gastroenterology2019，25，28： | 43 |
| 2 | Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy显示文摘AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. | Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi | 2013 | World Journal of Gastroenterology2013，19，2： | 12 |
| 3 | Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C显示文摘AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to IFN.METHODS:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively determined.RESULTS: Twenty-five patients completed IFN therapy.Eight patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy subjects.In vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C. | Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki | 2004 | World Journal of Gastroenterology2004，10，5： | 12 |
| 4 | Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function显示文摘 | Taihei Ito Shin Itakura Ivan Todorov Jeffrey Rawson Sadaki Asari Jonathan Shintaku Indu Nair Kevin Ferreri Fouad Kandeel Yoko Mullen | 2010 | Transplantation2010，，12： | 3 |
| 5 | Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer显示文摘 | Tang RF Itakura J Aikawa T | | 0，，： | 2 |
| 6 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 7 | Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer显示文摘 | Tang RF Itakura J Aikawa T | 2001 | Pancreas2001，22，3： | 2 |
| 8 | Rencent advances in panreaticobiliary maljunction显示文摘 | Matsumoto Y Fujii H Itakura J | 2002 | J Hepatobiliary pancreat surg2002，9，1： | 1 |
| 9 | Targeting lipid metabolism in the treatment of hepatitis C virus infection 显示文摘 | Amemiya F Maekawa S Itakura Y | 2008 | J Infeet Dis2008，197，3： | 1 |
| 10 | Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction 显示文摘 | Knowles JW Wang H Itakura H | 2007 | Am Heart J2007，154，6： | 1 |
| 11 | Overexpression of lymphangiogenie growth factor VEGF-C in human pancreatic cancer显示文摘 | Itakura J Aikawa T | 2001 | Pancreas2001，22，3： | 1 |
| 12 | Intermittent ad ministration of brain-derived neurotrophic factor (BDNF) ameliorates glucose metabolism and prevents pancreatic exhaustion in diabetic miee显示文摘 | Yamanaka M Itakura Y Ono-Kishino M | 2008 | J Biosci Bioeng2008，105，4： | 1 |
| 13 | Fabrication of high frequency SAW filters from 5 to 10 GHz using SiO/sub 2//ZnO/diamond structure显示文摘 | Nakahata H Hachigo A Itakura K | 2000 | Ultrasonics Symposium IEEE2000，1，： | 1 |
| 14 | Hepatic segmentectomy on primary liver cancer with sisus inversus totalis显示文摘 | Kamiike W Itakura T Tanaka H | 1996 | HPB Surg1996，9，3： | 1 |
| 15 | High incidence of synchronous or metachronous breast cancer in patients with malignant and benign thyroid tumor or tumor-liKe disorders显示文摘 | Nio Y Iguchi C Itakura M | 2009 | Anticancer Research2009，29，5： | 1 |
| 16 | Prospective randomized crossover trial of combination therapy with bezafibrate and UDCA for primary biliary cirrhosis显示文摘 | Itakura J Izumi N Nishimura Y | 2004 | Hepatol Res2004，29，： | 1 |
| 17 | Over expression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer显示文摘 | TANG R F ITAKURA I AIKAWA T | 2001 | Pacreas2001，22，3： | 1 |
| 18 | Copper deficiency during total parenteral nutrition: clinical analysis of three cases 显示文摘 | Futijita M Itakura T Takagi Y | 1989 | J Parent Enter Nutr1989，13，： | 1 |
| 19 | Inhibition of ocular angiogenesis by an adenovirus carrying the human von Hippel-Lindau tumor-suppressor gene in vivo显示文摘 | Akiyama H Tanaka T Itakura H | 2004 | Invest Ophthalmol Vis Sci2004，45，5： | 1 |
| 20 | Visuospatial impairment and activities of daily living in patients with Parkinson's disease: a quantitative assessment of the cube-copying task显示文摘 | Maeshima S Itakura T Nakagawa M | 1997 | Am J Phys Med Rehabil1997，76，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员