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| 1 | Trend in gastric cancer:35 years of surgical experience in Japan显示文摘AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring surgery.RESULTS:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed pe-riod.Interestingly,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to decrease.The incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic surveillance.As a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly improved.CONCLUSION:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention. | Keishi Yamashita Shinichi Sakuramoto Masayuki Nemoto Tomotaka Shibata Hiroaki Mieno Natsuya Katada Shiroh Kikuchi Masahiko Watanabe | 2011 | World Journal of Gastroenterology2011，17，29： | 11 |
| 2 | Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors显示文摘AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone.METHODS This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from baseline.RESULTS Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on average.CONCLUSION Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation. | Ryuma Urahama Masaya Uesato Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro Matsubara | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 3 |
| 3 | Octaarginine-modified liposomes:enhanced cellular uptake and controlled intracellular trafficking显示文摘 | LKRAMY A KENTARO K SHIROH F | 2008 | International Journal of Pharmaceutics2008，354，： | 1 |
| 4 | Octaarginine-modified li- posomes: enhanced cellular uptake and controlled intracellular trafficking显示文摘 | Ikramy AK Kentard K Shiroh F | 2008 | Int J Pharm2008，354，12： | 1 |
| 5 | Loss of expression of DNA repair enzymes MGMT,hMLH1,and hMSH2 during tumor progression in gastric cancer显示文摘 | Yoshihiko K Kohji M Shiroh M | 2003 | Gastric Cancer2003，6，： | 1 |
| 6 | Transfusion Alert for Patients with Curable Cancer显示文摘 | Keishi Yamashita Shinichi Sakuramoto Shiroh Kikuchi Natsuya Katada Nobuyuki Kobayashi Masahiko Watanabe | 2007 | World Journal of Surgery2007，，12： | 1 |
| 7 | Possible existense of common internalization mechanisms among arginine-rich peptides显示文摘 | Yomoki S Shiroh F Miki N | 2002 | J Biochem2002，277，4： | 1 |
| 8 | Predictor of respiratory disturbances during gastric endoscopic submucosal dissection under deep sedation显示文摘BACKGROUND Sedation is commonly performed for the endoscopic submucosal dissection(ESD)of early gastric cancer.Severe hypoxemia occasionally occurs due to the respiratory depression during sedation.AIM To establish predictive models for respiratory depression during sedation for ESD.METHODS Thirty-five adult patients undergoing sedation using propofol and pentazocine for gastric ESDs participated in this prospective observational study.Preoperatively,a portable sleep monitor and STOP questionnaires,which are the established screening tools for sleep apnea syndrome,were utilized.Respiration during sedation was assessed by a standard polysomnography technique including the pulse oximeter,nasal pressure sensor,nasal thermistor sensor,and chest and abdominal respiratory motion sensors.The apnea-hypopnea index(AHI)was obtained using a preoperative portable sleep monitor and polysomnography during ESD.A predictive model for the AHI during sedation was developed using either the preoperative AHI or STOP questionnaire score.RESULTS All ESDs were completed successfully and without complications.Seventeen patients(49%)had a preoperative AHI greater than 5/h.The intraoperative AHI was significantly greater than the preoperative AHI(12.8±7.6 events/h vs 9.35±11.0 events/h,P=0.049).Among the potential predictive variables,age,body mass index,STOP questionnaire score,and preoperative AHI were significantly correlated with AHI during sedation.Multiple linear regression analysis determined either STOP questionnaire score or preoperative AHI as independent predictors for intraoperative AHI≥30/h(area under the curve[AUC]:0.707 and 0.833,respectively)and AHI between 15 and 30/h(AUC:0.761 and 0.778,respectively).CONCLUSION The cost-effective STOP questionnaire shows performance for predicting abnormal breathing during sedation for ESD that was equivalent to that of preoperative portable sleep monitoring. | Mizuho Aikawa Masaya Uesato Ryuma Urahama Koichi Hayano Reiko Kunii Yohei Kawasaki Shiroh Isono Hisahiro Matsubara | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 1 |
| 9 | Loss of expression of DNA repair enzymes MGMT,hMLH1 and h MSH2 during tumor progression in gastric cancer显示文摘 | Yoshihiko Kitajima Kohji Miyazaki Shiroh Matsukura | 2003 | The Gastric Cancer2003，6，： | 1 |
| 10 | Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking显示文摘 | Ikramy A. Khalil Kentaro Kogure Shiroh Futaki Hideyoshi Harashima | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 11 | Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms显示文摘 | | 2002 | Int J Pharm2002，245，12： | 1 |
| 12 | Possible existense of common internalization mechanisms among arginine-rich peptides显示文摘 | Yomoki S Shiroh F Miki N | 2002 | J Biochem2002，277，4： | 1 |
| 13 | Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d -isomer peptides consisting of Pas and the p53 C-terminus显示文摘 | Yutaka Ueda Fan-Yan Wei Taku-ichiro Hide Hiroyuki Michiue Kentaro Takayama Taku Kaitsuka Hideo Nakamura Keishi Makino Jun-ichi Kuratsu Shiroh Futaki Kazuhito Tomizawa | 2012 | Biomaterials2012，，35： | 1 |
| 14 | Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking显示文摘 | Ikramy A. Khalil Kentaro Kogure Shiroh Futaki Hideyoshi Harashima | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
| 15 | Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer显示文摘 | Yoshihiko Kitajima Kohji Miyazaki Shiroh Matsukura Masayuki Tanaka Mutsuo Sekiguchi | 2003 | Gastric Cancer2003，，2： | 1 |
| 16 | Dose-dependent effects of mandibular advancement on pharyngeal mechanics and nocturnal oxygenation in pationts with sleep-disordered breathing显示文摘 | Jiro Kato Shiroh Isono Atsuko Tanaka | 2000 | Chest2000，117，： | 1 |
| 17 | Obstructive sleep apnea of obese adults: pathophysiology and perioperative airway manage- ment显示文摘 | Shiroh I | 2009 | Anesthesiology2009，110，4： | 1 |
| 18 | Octaarginine -modified liposomes : Enhanced cellular uptake and controlled in-tracellular trafficking显示文摘 | Ikramy AK Kentaro Kogure Shiroh Futaki | 2008 | Int J Pharm2008，354，： | 1 |
| 19 | Antibacterial activity inducible in the haemolymph of the silkworm, Bombyx mori, by injection of formalin-treated Escherichia coli K-12 during the fifth larval instar and pharate adult development显示文摘 | MOTOYUKI S HIROMASA I SHIROH J | 1992 | Comp Biochem Physiol1992，101，12： | 1 |
| 20 | Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking显示文摘 | Ikramy A. Khalil Kentaro Kogure Shiroh Futaki Hideyoshi Harashima | 2007 | International Journal of Pharmaceutics2007，，1： | 1 |
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