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| 1 | 美国老年护理的发展经验对中国护理的启示显示文摘中国已进入老龄化社会[1],如何解决好老年人的医疗保健是可持续发展中的重大问题之一.护士在老年人照顾中可以而且能够发挥独特的作用,不但可提高老年人的护理质量,更重要的是改善老年人的生活质量.近20年来,在发达国家特别是美国的老年护理取得了很大进展,有必要结合国情学习借鉴其经验,从护理教育、实践及研究等方面思考中国老年护理如何应对人口老龄化的挑战. | 刘雪琴 李漓 Keela Herr | 2005 | 中华护理杂志2005，40，12： | 103 |
| 2 | 美国疼痛治疗护士的职责与认证显示文摘尽管疼痛已被作为“第五生命体征”,但疼痛依然未得到有效治疗。护士在疼痛治疗中应该而且可以发挥重要的作用。2005年10月,美国护士学会(Amefican Nurses Associ ation,ANA)属下的美国护士认证中心(American Nudes Credentialing Center,ANCC)和美国疼痛治疗护理协会(American Society for Pain Management Nursing,ASPMN)合作,启动了疼痛治疗普通专科认证考试。至2007年底,共746名护士通过了疼痛治疗认证考试。本文介绍美国疼痛治疗护士的工作职责及认证要求,以期为提高我国疼痛治疗护理水平提供借鉴。 | 李漓 Keela Herr | 2009 | 中华护理杂志2009，44，10： | 57 |
| 3 | The effect of the substrate on the Raman and photoluminescence emission of single-layer MoS2显示文摘 | Michele Buscema Gary A. Steele Herre S. J. van der Zant &ndres Castellanos-Gomez | 2014 | Nano Research2014，7，4： | 28 |
| 4 | Folded MoS2 layers with reduced interlayer coupling显示文摘 | Andres Castellanos-Gomez Herre S. J. van der Zant Gary A. Steele | 2014 | Nano Research2014，7，4： | 9 |
| 5 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 6 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 7 | CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath显示文摘钙绑定酷氨酸调整 phosphorylation 的蛋白质(CABYR ) 是高度多态的钙绑定 tyrosine-/threonine-phosphorylated 和 serine-/threonine-phosphorylated 涉及 capacitation 的含纤维的鞘(FS ) 蛋白质。一个通常认为的领域(氨基酸 12 鈥 ? 8 ) 对类型 II 营地依赖者蛋白质 kinase A (RII ) dimerisation 和抛锚 kinase 蛋白质(AKAP ) 的规章的子单元相应在 N 终点的蛋白质 kinase A 的有约束力的领域建议那 CABYR 可以自我装配并且绑在 AKAP。而且,有证据, CABYR 与 AKAP 限制了相互作用。然而,推进在 CABYR 之间的证据和新关系,包括 AKAP,另外的 FS 蛋白质将在理解 FS 的基本生理学是有用的。在这研究,为不可溶解的蛋白质的 co-immunoprecipitation 的新策略,以及在有集体 spectrometry 和西方的污点的联合的标准 co-immunoprecipitation 方法,被采用探索在 CABYR, AKAP3 和 Ropporin 之间的关系。结果证明 AKAP3 是有由 anti-CABYR-A polyclonal 抗体的 CABYR 的 co-immunoprecipitated,并且,相反地, CABYR 也是有由 anti-AKAP3 polyclonal 抗体的 AKAP3 的 co-immunoprecipitated。包含蛋白质的另一象 RII 一样域, Ropporin,也是有 CABYR 的 co-immunoprecipitated,显示 Ropporin 是 CABYR 的绑定之一合伙。在 CABYR, AKAP3 和 Ropporin 之间的相互作用被酵母证实二混血儿的试金。进一步的分析显示出那 CABYR 不仅由它的 RII 领域绑在 AKAP3 而且除象 RII 一样领域以外通过另外的区域绑在 Ropporin。这是 CABYR 变体形成的第一示范不仅有 scaffolding 蛋白质 AKAP3 而且与在人的精子 FS 的另一象 RII 一样包含域的蛋白质的建筑群。 | Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz Charles J Flickinger John C Herr | 2011 | Asian Journal of Andrology2011，13，2： | 5 |
| 8 | Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults显示文摘 | Sabine M.J.M. Straus Jan A. Kors Marie L. De Bruin Cornelis S. van der Hooft Albert Hofman Jan Heeringa Jaap W. Deckers J. Herre Kingma Miriam C.J.M. Sturkenboom Bruno H. Ch. Stricker Jacqueline C.M. Witteman | 2006 | Journal of the American College of Cardiology2006，，2： | 4 |
| 9 | Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss显示文摘 | Brian D. Herr Sam J. Marzo | 2005 | Otolaryngology - Head and Neck Surgery2005，，4： | 3 |
| 10 | The Effect of Restaging Transurethral Resection on Recurrence and Progression Rates in Patients with Nonmuscle Invasive Bladder Cancer Treated with Intravesical Bacillus Calmette-Guérin显示文摘 | John P. Sfakianos Philip H. Kim A. Ari Hakimi Harry W. Herr | 2014 | The Journal of Urology2014，，2： | 2 |
| 11 | Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors显示文摘AIM:To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90(90 Y) spheres.METHODS:From September 2003 to January 2012,379 procedures of liver radioembolization(RE) using resin microspheres loaded with 90 Y were performed in our center.We have retrospectively compiled the data from 379 RE procedures performed in our center.We report a comprehensive clinical,analytical,endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the treatment.RESULTS:Six patients(1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after RE.The mean time between RE and the appearance of symptoms was 5 wk.Only one patient required endoscopic and surgical treatment.The incidence of gastrointestinal ulcerations was 3.75%(3/80) when only planar images were used for the pre-treatment evaluation.It was reduced to 1%(3/299) when singlephoton emission computed tomography(SPECT) images were also performed.The symptoms that lasted for a longer time were nausea and vomiting,until 25 mo after the treatment.CONCLUSION:All patients were free from severe symptoms at the end of follow-up.The routine use of SPECT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 90 Y particles. | Iago Rodríguez-Lago Cristina Carretero Maite Herráiz José C Subtil Maite Betés Macarena Rodríguez-Fraile Jesús J Sola José I Bilbao Miguel Muoz-Navas Bruno Sangro | 2013 | World Journal of Gastroenterology2013，19，19： | 2 |
| 12 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 13 | 外科护士疼痛管理核心能力教育项目的实施与评价显示文摘目的探讨疼痛管理核心能力教育项目对外科护士疼痛知识和疼痛护理实践的影响。方法由多学科团队设计并实施外科护士疼痛护理核心能力教育项目,每周8 h,共2周,内容包括疼痛的多维性质、疼痛评估、药物与非药物治疗以及知识应用等,采用讲授、个案讨论等多种形式的教学方法。采用临床疼痛知识测验(the Clinical Pain Knowledge Test,CPKT)在课程前后对来自17个外科病区的护士进行评估,课程前后分别评估了135、107名护士。在课程前1周及课程后第5周按各病区手术量随机抽取203份患者病历,收集患者的术后疼痛护理实践及疼痛强度评分记录。结果课程实施后护士的临床疼痛知识测验评分由(45.6%±12.3%)提高到(54.2%±10.2%)(t=5.786,P<0.001)。术后疼痛护理实践记录中,疼痛评估记录的比例由59.6%增加到74.9%(χ^(2)=10.746,P=0.001),使用疼痛强度评估工具的比例由81.8%增加到95.4%(χ^(2)=13.079,P<0.001),肌内注射非阿片类药物的比例由12.6%降至2.7%(χ2=7.598,P=0.006)。患者手术当天及术后3 d疼痛程度(最痛平均分)均降低(P<0.05)。结论对外科护士实施疼痛管理核心能力教育项目可提高其疼痛管理核心能力知识水平,改善部分疼痛护理实践,减轻患者的术后疼痛程度。 | 刘雪莲 李漓 王灵晓 Keela Herr 陈秋婵 | 2021 | International Journal of Nursing Sciences2021，8，1： | 2 |
| 14 | 人精子纤维鞘多态性蛋白CABYR的寡聚化作用显示文摘目的验证钙结合酪氨酸磷酸化调节蛋白(calcium-binding tyrosine phosphorylation-regulated protein,CABYR)不同异构体之间寡聚体的形成。方法人精子提取物进行非还原和还原条件下的SDS-PAGE、二维IEF/SDS-PAGE、对角线电泳、二维blue native/SDS-PAGE电泳和免疫印迹分析。结果在人精子中丰度最高的CABYR亚型是相对分子质量86×103仅含CRA编码区表达序列,具有钙结合能力的异构体。同时也存在既含CRA又含CRB编码区表达序列的CABYR亚型。在非还原条件下,丰度最高的130×103二聚体是由仅含CRA表达序列的86×103异构体和既含CRA又含CRB表达序列的50×103异构体组成。(200-220)×103寡聚体是由86×103、50×103异构体,以及35×103(可能既含CRA又含CRB表达序列)的异构体和仅含CRA表达序列的30×103异构体组成。结论证实CABYR异构体可形成寡聚体,CABYR主要通过86×103和50×103异构体形成异质二聚体,与其他CABYR异构体结合进一步形成更大的寡聚体,参与了人精子纤维鞘超分子结构的装配和形成。 | 李彦锋 何畏 梁培禾 张军 孙中义 张勇 王洛夫 靳风烁 Charles J. Flickinger John C. Herr | 2010 | 第三军医大学学报2010，32，21： | 2 |
| 15 | THE VALUE OF A SECOND TRANSURETHRAL RESECTION IN EVALUATING PATIENTS WITH BLADDER TUMORS显示文摘 | HARRY W. HERR | 1999 | The Journal of Urology1999，，1： | 2 |
| 16 | Oolemmal proteomics - identification of highly abundant heat shock proteins and molecular chaperones in the mature mouse egg and their localization on the plasma membrane显示文摘 | Calvert ME Digilio LC Herr JC | 2003 | Reprod Biol Endocrinol2003，141，： | 2 |
| 17 | LPA Receptors: Subtypes and Biological Actions显示文摘 | Ji Woong Choi Deron R. Herr Kyoko Noguchi Yun C. Yung Chang-Wook Lee Tetsuji Mutoh Mu-En Lin Siew T. Teo Kristine E. Park Alycia N. Mosley Jerold Chun | 2010 | Annual Review of Pharmacology and Toxicology2010，，： | 2 |
| 18 | Autolcgous ehondroeyte implantation and osteoehondral cylinder transplantation in cartilage repair of the knee joint: a prospective, comparative trial显示文摘 | Horas U Pelinkovle D Herr G | 2003 | J Bone Joint Surg Am2003，85，： | 1 |
| 19 | Two-dimensionalgel electrophoretie analysis of vectorially labeled surface proteins of human spermatozoa 显示文摘 | Naaby Hansen S Flickinger C J Herr J C | 1997 | Biol Reprod1997，56，3： | 1 |
| 20 | TRAIL/Apo-2 ligand-induced apoptosis in human T cells显示文摘 | Herr I Boehler T | 1998 | Eur J Immunol1998，28，1： | 1 |
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