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1Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections.doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik 2016World Journal of Gastrointestinal Surgery2016,8,1:8
2中国地方政府性债务规模估算显示文摘中央政府决意遏制政府性债务规模,但道德风险问题尚未得到解决本文列出未来5年政府可能采取的解决措施我们估计地方政府性债务规模可能达到21.9-24.4万亿元(约合3.6-4.0万亿美元),占GDP的38-42%,表1显示了我们对地方政府性债务规模的估算过程。对于这样一个规模,市场应该不会感到吃惊,我们在此前发布的亚洲债务报告中估算中国地方政府债务规模为20万亿元~①。我们预计,相关部门公布对地方政府性债务规模的估算将为2014年财政体制改革创造动力,同时也为更全面解决地方投融资平台债务问题寻找路径。王志浩 申岚 李炜 Dorris Chen David Yin Jennifer Law 2013金融发展评论2013,,12:6
3Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa 2013Critical Care Medicine2013,,1:6
4Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC.Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry 2017World Journal of Hepatology2017,9,9:4
5Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande 2019Horticulture Research2019,6,1:3
6Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa 2013Critical Care Medicine2013,,1:2
7RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement.Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace 2020Horticulture Research2020,7,1:2
8The removal of heavy metals from aqueous solutions by sawdust adsorption — removal of lead and comparison of its adsorption with copper显示文摘Bin Yu Y Zhang Alka Shukla Shyam S Shukla Kenneth L Dorris 2001Journal of Hazardous Materials2001,,1:2
9Sarcopenia and Mortality after Liver Transplantation显示文摘Michael J. Englesbe Shaun P. Patel Kevin He Raymond J. Lynch Douglas E. Schaubel Calista Harbaugh Sven A. Holcombe Stewart C. Wang Dorry L. Segev Christopher J. Sonnenday 2010Journal of the American College of Surgeons2010,,2:2
10Resveratrol induces extensive apoptosis by depolarizing mitochondrial membrance and activated caspase-9 in acute lymphoblastic leukemia cells显示文摘Dorrie J Geraucer H Wacdter Y 2001Cancer Res2001,61,12:1
11Inspection errors and statistical quality control:A survey显示文摘DORRIS A L FOOTE B L 1978AIIE Transactions1978,10,2:1
12Overview of flotation deinking显示文摘Dorris G Ben Y Ricard M 2011Progress in paper recycling2011,20,1:1
13Influence of hole geometry in the cavitation phenomena of diesel injectors, a numerical investigation显示文摘Dorri A Lamani A Hoxha A 2009Goriva i masiva2009,48,3:1
14Removal ofnickel from aqueous solutions by sawdust显示文摘SHUKLA S S YU L J DORRIS K L 2005Journal ofHazardous Materials2005,121,123:1
15An assessment of Motorola CodeLink microarray performance for gene expression profiling applications显示文摘RAMAKRISHNAN R DORRIS D LULINSKY A 2002Nucleic Acids Res2002,30,7:1
16Scheduling part-time and mixed-skilled workers to maximize employee satisfaction 显示文摘AKBARI M ZANDIEH M DORRI B 2013Inter- national Journal of Advonced Manufacturing Technology2013,64,:1
17Removal of nickel fromaqueous solutions by sawdust显示文摘Shukla S S Yu L J Dorris K L 2005Journal of Hazardous Materials2005,121,123:1
18Effect of Initial pH on the Deflaking Rate of Recovered Papers显示文摘F Brouillette C Daneault G M Dorris 2003Pulp and Paper Canada2003,104,7:1
19显示文摘Dorris S E Mason T O 1988J Am Ceram Soc1988,71,5:1
20Frailty as a Predictor of Surgical Outcomes in Older Patients显示文摘Martin A. Makary Dorry L. Segev Peter J. Pronovost Dora Syin Karen Bandeen-Roche Purvi Patel Ryan Takenaga Lara Devgan Christine G. Holzmueller Jing Tian Linda P. Fried 2010Journal of the American College of Surgeons2010,,6:1
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