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| 1 | Diabetes mellitus and hypothyroidism: Strange bedfellows or mutual companions?显示文摘Clinicians should be cognizant of the close relationship that exists between two of the most common endocrine disorders, primary hypothyroidism and diabetes mellitus. This applies to patients with both type 1 and type 2 diabetes mellitus(T1DM and T2 DM respectively). However, the association is greater in T1 DM, probably because of the shared autoimmune predisposition. In patients with T2 DM, the relationship is somewhat weaker and the explanation less clear-cut. Factors such as dietary iodine deficiency, metformin-induced thyroid stimulating hormone suppression and poor glycemic control may all be implicated. Further translational research is required for greater clarification. Biochemical screening for abnormal thyroid function in individuals who have diabetes is warranted, particularly in females with T1 DM, and therapy with L-thyroxine appropriately instituted if hypothyroidism is confirmed. | Barry I Joffe Larry A Distiller | 2014 | World Journal of Diabetes2014，5，6： | 11 |
| 2 | Semen quality analysis and the idea of normal fertility显示文摘世界健康组织() 广泛地为精液分析修订了它的手册,并且寻求为精液质量参数提供参考书限制。这提出被“正常”意味着的问题(排除这个术语的使用表示 Gaussian 分布) 。它能在完全统计的意义被拿,用表示反常水平的一个生物学上任意的截止的点,典型地极端 5% 人口。或者,“正常”能根据规度和反常的生物概念被定义,以生物功能在变得损害的点。例如,这些的任何一个能在描述的传染病学,但是在富饶,两精液质量和功能的富饶(怀孕的时间) 的情况中被使用学习趋势是没有清楚的阀值的连续变量。WHO 手册使用正常的生物意思,因为它为最近生了花了 12 个月或更少怀孕的怀孕的人提供精液参数分布。然而,确实被需要的,是一样的信息另外的方法在附近:给特别精液测试结果,什么,并且多长应该以构思的能力被期望它是可能的拿。在考虑流行病学的研究,焦点主要在内部比较,而非引用限制上,但是如果更多的注意对绝对层次并且到这些以函数鈥攊n 意味着另外的词的被给予,它将是有益的,如果数据更好生物学上被校准。 | Michael Joffe | 2010 | Asian Journal of Andrology2010，12，1： | 7 |
| 3 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 4 | 精液质量分析与正常生育力的概念显示文摘世界卫生组织(WHO)为对精液质量参数提供参考范围,对《世界卫生组织人类精液分析实验室技术手册》(简称手册)进行了大幅修订。这引发如何定义'正常'(不包括用此概念表示高斯分布)的问题。其可作为一个纯粹的统计学概念,使用生物学上主观设定的切点值表示异常水平,通常为末端5%的人群。'正常'的另一定义也可根据生物学上常态和非常态的概念,表示生物学功能受损的临界点。这两者都可以用于描述性流行病学,例如研究变化趋势。但在考虑生育时,精液质量和生育力(使配偶妊娠的时间)两者都是连续变量,缺乏确定的阈值。手册使用了生物学意义上的'正常',因为提供的是在12个月或更短时间内使配偶妊娠男性的精液参数分布状态。但真正需要的却是反向的相同信息:获得一个特定的精液检测结果,预期生育能力如何,确定需要大概多长时间使配偶妊娠。从流行病学研究角度考虑,研究重点主要在于内部比较,而不是参考范围。如果更关注绝对值及其功能意义,换言之,如果精液分析数据从生物学角度上得到更好的校准,这将大有裨益。 | Joffe M 甄威 郑芹珠 曹少锋 李铮 黄学锋 | 2010 | 国际生殖健康/计划生育杂志2010，29，3： | 3 |
| 5 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 6 | COPING AND DEFENSE IN RELATION TO ACCOMMODATION AMONG A SAMPLE OF BLIND MEN显示文摘 | PAUL E. JOFFE BERNARD A. BAST | 1978 | The Journal of Nervous and Mental Disease1978，，8： | 2 |
| 7 | Predicting early outcomes of liver transplantation in young children: The EARLY study显示文摘AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015.Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperative day 2-5(OR 0.92; 0.86-0.98; P = 0.016), and split/reduced(OR 0.06; 0.01, 0.78; P = 0.032) vs whole-liver graft. CONCLUSION In young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation. | Rashid Alobaidi Natalie Anton Dominic Cave Elham Khodayari Moez Ari R Joffe | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 8 | An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy显示文摘 | Joffe H Groninger H Soares C | 2001 | J Womens Health Gend Based Med2001，10，： | 1 |
| 9 | Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis 显示文摘 | Dessein PH Joffe BI Stanwix AE | 2004 | Thyroid2004，14，6： | 1 |
| 10 | Upper-extremity deep vein thrombosis: a prospective registry of 592 patients显示文摘 | Joffe HV Kucher N Tapson VF | 2004 | Circulation2004，110，12： | 1 |
| 11 | Abnormal cardiac function in the strepotozocin-induced non-insulin-dependent diabetic rat: nonivasive assessment with Doppler echocardiography and contribution of nitric oxide pathway显示文摘 | Joffe Ⅱ Travers KE Perreault-Micale CL | | J Am Coll Cardiol0，，： | 1 |
| 12 | Abnormal cardiac function in the streptozotocin- induced non- insulin- dependent diabetic rat:noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway显示文摘 | Joffe I I Travers K E Perreault- Micale C L | | J Am Coll0，，： | 1 |
| 13 | Validation of computer - assisted manufacture of titanium plates for cranioplasty显示文摘 | Joffe JM Nicoll SR Richards R | 1999 | Int J Oral Maxillofac Surg1999，28，4： | 1 |
| 14 | A prospective study of computer- aided design and manufacture of titanium plate for cranioplasty and its clinical outcome 显示文摘 | Joffe J Harris M Kahugu F | 1999 | Br J Neurosurg1999，13，6： | 1 |
| 15 | Healthcare systems--an inter- national review: an overview显示文摘 | Lameire N Joffe P Wiedemann M | 1999 | Nephrol Dial Transplant1999，14，6： | 1 |
| 16 | Continuous flow residence time distribution function characterization显示文摘 | Haas C N Joffe J Heath M S | | 0，，02： | 1 |
| 17 | Should thyroid replacement therapy be considered for patients with treatment refractory depression显示文摘 | Joffe RT | 2002 | J Psychiatry Neurosci2002，27，1： | 1 |
| 18 | Outcomes from an inter- provincial program of newborn open heart surgery 显示文摘 | Robertson CM Joffe AR Sauve RS | 2004 | J Pediatr2004，144，： | 1 |
| 19 | A prospective study of computer- aided design and manufacture of titanium plate for cranioplasty and its clinical outcome 显示文摘 | Joffe J Harris M Kahugu F | 1999 | Br J Neurosurg1999，13，6： | 1 |
| 20 | Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: Noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway显示文摘 | JOFFE I I TRAVERS K E PERREAULT-MICALE C L | 1999 | J Am Coll Cardiol1999，34，7： | 1 |
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