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| 1 | Management of perianal fistulas in Crohn's disease:An upto-date review显示文摘Perianal disease is one of the most disabling manifestations of Crohn's disease.A multidisciplinary approach of gastroenterologist,colorectal surgeon and radiologist is necessary for its management.A correct diagnosis,based on endoscopy,magnetic resonance imaging,endoanal ultrasound and examination under anesthesia,is crucial for perianal fistula treatment.Available medical and surgical therapies are discussedin this review,including new local treatment modalities that are under investigation. | Manuela Marzo Carla Felice Daniela Pugliese Gianluca Andrisani Giammarco Mocci Alessandro Armuzzi Luisa Guidi | 2015 | World Journal of Gastroenterology2015，21，5： | 5 |
| 2 | Intratympanic steroid perfusion for refractory sudden sensorineural hearing loss显示文摘 | Brian D. Herr Sam J. Marzo | 2005 | Otolaryngology - Head and Neck Surgery2005，，4： | 3 |
| 3 | Multiparticle Production on Hydrogen, Argon and Xenon Targets in a Streamer Chamber by 200-GeV/c Proton and Antiproton Beams 显示文摘 | Marzo C D Palma M D Distante A | 1982 | Phys Rev D1982，25，： | 2 |
| 4 | High-performance liquid chromatographic assay of ampicillin and its prodrug lenampicillin显示文摘 | Marzo A Mont N Ripamonti M | 1990 | JChromatogr1990，16，： | 2 |
| 5 | HEART RATE VARIABILITY DURING HIGH-INTENSITY EXERCISE显示文摘The aim of this paper is to describe and analyse the behaviour of heart rate variability(HRV)during constant-load,high-intensity exercise using a time frequency analysis(Wavelet Transform).Eleven elite cyclists took part in the study(age:18.6±3.0 years;VO_(2max):4.88±0.61 litres·min^(-1)).Initially,all subjects performed an incremental cycloergometer test to determine load power in a constant load-test(379.55±36.02 W;89.0%).HRV declined dramatically from the start of testing(p<0.05).The behaviour of power spectral density within the LF band mirrored that of total energy,recording a significant decrease from the outset LF peaks fell rapidly thereafter,remaining stable until the end of the test.HF-VHF fell sharply in the first 20 to 30 seconds.The relative weighting(%) of HF-VHF was inverted with the onset of fatigue,[1.6%at the start,7.1(p<0.05) at the end of the first phase,and 43.1%(p<0.05) at the end of the test].HF-VHF_(peak) displayed three phases:a moderate initial increase,followed by a slight fall,thereafter increasing to the end of the test.The LF/HF-VHF ratio increased at the start,later falling progressively until the end of the first phase and remaining around minimal values until the end of the test. | SARMIENTO Samuel GARCIA-MANSO Juan Manuel MARTIN-GONZALEZ Juan Manuel VA-AMONDE Diana CALDERóN Javier DA SILVA-GRIGOLETTO Marzo Edir | 2013 | Journal of Systems Science & Complexity2013，26，1： | 2 |
| 6 | If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease显示文摘Antibodies are employed ubiquitously in biomedical sciences,including for diagnostics and therapeutics.One of the most important uses is for immunohistochemical(IHC)staining,a process that has been improving and evolving over decades.IHC is useful when properly employed,yet misuse of the method is widespread and contributes to the“reproducibility crisis”in science.We report some of the common problems encountered with IHC assays,and direct readers to a wealth of literature documenting and providing some solutions to this problem.We also describe a series of vignettes that include our approach to analytical validation of antibodies and IHC assays that have facilitated a number of biological insights into prostate cancer and the refutation of a controversial association of a viral etiology in gliomas.We postulate that a great deal of the problem with lack of accuracy in IHC assays stems from the lack of awareness by researchers for the critical necessity for end-users to validate IHC antibodies and assays in their laboratories,regardless of manufacturer claims or past publications.We suggest that one reason for the pervasive lack of end-user validation for research antibodies is that researchers fail to realize that there are two general classes of antibodies employed in IHC.First,there are antibodies that are“clinical grade”reagents used by pathologists to help render diagnoses that influence patient treatment.Such diagnostic antibodies,which tend to be highly validated prior to clinical implementation,are in the vast minority(e.g.<500).The other main class of antibodies are“research grade”antibodies(now numbering>3800000),which are often not extensively validated prior to commercialization.Given increased awareness of the problem,both the United States,National Institutes of Health and some journals are requiring investigators to provide evidence of specificity of their antibody-based assays. | Karen S.Sfanos Srinivasan Yegnasubramanian William G.Nelson Tamara L.Lotan Ibrahim Kulac Jessica L.Hicks Qizhi Zheng Charles J.Bieberich Michael C.Haffner Angelo M.De Marzo | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 7 | Prevalence and natural history of hepatitis B and C infections in a large population of IBD patients treated with anti-tumor necrosis factor-α agents显示文摘 | Alfredo Papa Carla Felice Manuela Marzo Gianluca Andrisani Alessandro Armuzzi Marcello Covino Giammarco Mocci Daniela Pugliese Italo De Vitis Antonio Gasbarrini Gian Lodovico Rapaccini Luisa Guidi | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 8 | Native opioid-like peptides in Squilla mantis ganglia显示文摘 | MARINO G PALMISANO A DI MARZO V | 1995 | Peptides1995，6，3： | 1 |
| 9 | Low erythropoietin serum levels are associated with angiographic no-reflow after primary intervention for acute myocardial infarction显示文摘 | NICCOLI G MARZO F PAGLIA A | 2007 | Circulation2007，116，： | 1 |
| 10 | Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis 显示文摘 | MARZO I BRENNER C ZAMZAMI N | 1998 | Science1998，281，5385： | 1 |
| 11 | The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders显示文摘 | van der Stelt M Di Marzo V | 2003 | Eur J Pharmacol2003，480，1： | 1 |
| 12 | Embryo culture of Fraxinus omusand Sorbus domestica removes seed dormancy 显示文摘 | Arrilllaga I Marzo T Segura J | 1992 | HortScience1992，27，4： | 1 |
| 13 | Overexpression of hypoxia-inducible factor lalpha in common human cancers and their metastases显示文摘 | Zhong H De Marzo AM Laughner E | 1999 | Cancer Res1999，59，22： | 1 |
| 14 | Popliteal cysts: a current review 显示文摘 | Herman AM Marzo JM | 2014 | Orthopedics2014，37，： | 1 |
| 15 | Development of two electronic bladder diaries: a patient and healthcare professionals pilot study 显示文摘 | MANGERA A MARZO A HERON N | 2014 | Neurourol Urodyn2014，33，7： | 1 |
| 16 | Lonidamine triggers apoptosis via a direct, Bcl-2 inhibited effect on the mitochondrial permeability transition pore显示文摘 | Ravagnan L Marzo I Costantini P | 1999 | Onco- gene1999，18，16： | 1 |
| 17 | Proligerative inflammatoryatrophy of the prostate:implications for prostatic carcinogenesis显示文摘 | De Marzo AM Marchi VL Epstein JI | 1999 | Am J Pathol1999，155，6： | 1 |
| 18 | Over expression of HIF-1α incommon human cancers and their metastases显示文摘 | Zhong H De Marzo AM Laughner E | 1999 | Cancer Res1999，59，22： | 1 |
| 19 | N - acetylcysteine the prevention of radio contrast - induced nephropathy 显示文摘 | Fishbane S Durham J H Marzo K | 2004 | J Am Soc Nephrol2004，15，2： | 1 |
| 20 | Persistent purulent drainage from the glans penis: atypical presentation of pyodenna gangrenosum显示文摘 | Gonzalgo ML de Lacerda DA De Marzo AM | 2003 | J Urol2003，169，5： | 1 |
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