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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 3 | Targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas显示文摘For patients with metastatic or locally advanced eyelid and periocular carcinoma not amenable to surgical excision, targeted therapies have shown efficacy with better tolerability compared to cytotoxic chemotherapy. Overexpression of epithelial growth factor receptor was found in squamous cell carcinomas. Vismodegib targets the mutation in the hedgehog pathway identified in basal cell carcinoma and basal cell nevus syndrome. Targeted therapies provide a novel and potentially effective treatment alternative for patients with eyelid carcinoma not amendable for surgery, including those with metastatic, locally advanced disease, advanced age, and significant comorbidities. High cost, need for long-term treatment, and toxicity are relative limitations. | Vivian T Yin Helen Merritt Bita Esmaeli | 2014 | World Journal of Clinical Cases2014，2，9： | 2 |
| 4 | Immunostimulatory DNA sequences necessary for effective intraderlmal gene immunization显示文摘 | Snato Y Mark R Helen T | 1996 | Science1996，273，： | 1 |
| 5 | Protracted release of the LHRH agonist avorelin (MF 6001) from two depot formulations in dogs and men显示文摘 | FRANGOIS B HELENE T SANDRINE D | 1997 | Lett Pept Sci1997，4，46： | 1 |
| 6 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 7 | Biodegradable fraction of organic carbon estimated under oxic and anoxic conditions显示文摘 | Helene M Vuillemin T Dispan J | 2003 | Water Research2003，37，： | 1 |
| 8 | Studies on the formation of furosine and pyridosine during acid hydrolysis of different amadori products of lysine显示文摘 | Krause R Knoll K Helen T | 2003 | European Food Research and Technology2003，216，4： | 1 |
| 9 | Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma显示文摘 | Deirdre T Helen C Andrew G J | 2008 | Vaccine2008，26，35： | 1 |
| 10 | Removal of NO by reversible adsorption on Fe-Mn based transition metal oxides显示文摘 | Huang Helen Y Yang Ralph T | 2001 | Langmuir2001，16，17： | 1 |
| 11 | Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone显示文摘 | Saadiq F El-Amin Mohamed Attawia Helen H Lu Asist K Shah Richard Chang Noreen J Hickok Rocky S Tuan Cato T Laurencin | 2002 | Journal of Orthopaedic Research2002，，1： | 1 |
| 12 | 查看详情显示文摘 | Anastasios E Helen B Spyros A Despina T | | 0，，31： | 1 |
| 13 | The force, power, and energy of the 100 meter sprint 显示文摘 | Helene O Yamashita M T | 2010 | American Journal of Physics2010，78，3： | 1 |
| 14 | Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations显示文摘 | Adele H Jane S Helen T | 2001 | Blood2001，97，： | 1 |
| 15 | Glycation compounds in peanuts显示文摘 | Welllner A Lena N Helen T | 2012 | European Food Research and Technology2012，234，3： | 1 |
| 16 | Influence of the nature of organic compounds on fine soil stabilization with cement显示文摘 | Helene T Josee D Jacques L | 2002 | Canada Geoteeh J2002，39，： | 1 |
| 17 | Age and composition of dikes in Southern Tibet: New comta'aints on the timing of east-west extension and its relationship to postcollisional volcanism显示文摘 | Helen W Simon T Simon K | 2001 | Geology2001，29，4： | 1 |
| 18 | Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA -induced Ca^2+ sensitization of contraction in vascular smooth muscle显示文摘 | Vincent S Helene L J Chrystelle C T | 2000 | J Bio Chem2000，275，21： | 1 |
| 19 | Attenuation of Proteasome-induced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss 显示文摘 | Helen J S Pradip Mukerji Michael J T | 2005 | Cancer Res2005，65，1： | 1 |
| 20 | Postconditioning during primary percutaneous coronary intervention: a review and meta-analysis显示文摘 | PETER R H HELENE T JAWDAT A | 2010 | Inter J Cardio2010，144，： | 1 |
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