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| 1 | Experimental and numerical study of the fragmentation of expanding warhead casings by using different numerical codes and solution techniques显示文摘There has been increasing interest in numerical simulations of fragmentation of expanding warheads in 3D.Accordingly there is a pressure on developers of leading commercial codes,such as LS-DYNA.AUTODYN and IMPETUS Afea.to implement the reliable fracture models and the efficient solution techniques.The applicability of the Johnson—Cook strength and fracture model is evaluated by comparing the fracture behaviour of an expanding steel casing of a warhead with experiments.The numerical codes and different numerical solution techniques,such as Eulerian,Lagrangian.Smooth particle hydrodynamics(SPH).and the corpuscular models recently implemented in IMPETUS Afea are compared.For the same solution techniques and material models we find that the codes give similar results.The SPH technique and the corpuscular technique are superior to the Eulerian technique and the Lagrangian technique(with erosion) when it is applied to materials that have fluid like behaviour such as the explosive and the tracer.The Eulerian technique gives much larger calculation time and both the Lagrangian and Eulerian techniques seem to give less agreement with our measurements.To more correctly simulate the fracture behaviours of the expanding steel casing,we applied that ductility decreases with strain rate.The phenomena may be explained by the realization of adiabatic shear bands.An implemented node splitting algorithm in IMPETUS Afea seems very promising. | John F.MOXNES Anne K.PRYTZ Фyvind FRФYLAND Siri KLOKKEHAUG Stian SKRIUDALEN Eva FRIIS Jan A.TELAND Cato DФRUM Gard ФDEGARDSTUEN | 2014 | Defence Technology(防务技术)2014，10，2： | 12 |
| 2 | Nanocomposites and bone regeneration显示文摘这张手稿用设计策略的织物集中于骨头修理 / 新生,并且加亮导致新奇 nanocomposite 系统的 nanobiotechnology 开发。大约 650 万破裂在美国每年发生,并且大约 550,000 个这些单个盒子要求了骨头接枝的申请。自然发生并且 allogenous 骨头最广泛地为骨头接枝被使用了基于的治疗;然而,象施主缺乏和感染的风险那样有重要问题。用合成、自然的 biomaterials 的选择被开发了,并且一些为要求骨头接枝的临床的应用程序是商业地可得到的。然而,设计很仔细模仿骨头织物在结构上,和罐头的理想的合成接枝仍然是大挑战在造骨细胞和祖先房间人口调制需要的功能。Nanobiomaterials,明确地, nanocomposites hydroxyapatite 创作了(哈) 或骨胶原极其正在答应接枝代用品。biocomposites 能被制作模仿本国的骨头织物的材料作文,并且另外,当使用 nano 时 -- 哈(减少的谷物尺寸) ,一个人模仿本国的骨头的结构的安排。骨头生物学和结构的好理解对骨头 mimicking 接枝代用品的开发批评。哈并且能进一步调制 regenerative/healing 的优秀 osteoconductive 性质处理跟随破裂损害的骨胶原展览。与另外的聚合 biomaterials 结合将增强因此做新奇 nano 的机械性质 -- 哈比得上人的骨头的基于的 composites。我们用 nanocomposites 在最近的研究上报导为部分骨头缺点的新生作为粒子和 nanofibers 被制作了。在 nanocomposites 的研究,在理想的未来发展加亮一个枢轴的角色整形外科植入设备,然而进一步的重要前进是必要的完成临床的使用。 | Roshan JAMES Meng DENG Cato T. LAURENCIN Sangamesh G. KUMBAR | 2011 | Frontiers of Materials Science2011，5，4： | 5 |
| 3 | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies显示文摘膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。 | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin | 2017 | Engineering2017，3，1： | 3 |
| 4 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 5 | Nanofiber–microsphere (nano-micro) matrices for bone regenerative engineering: a convergence approach toward matrix design显示文摘Bone is an essential organ for health and quality of life.Due to current shortfalls in therapy for bone tissue engineering,scientists have sought the application of synthetic materials as bone graft substitutes.As a composite organic/inorganic material with significant extra cellular matrix(ECM),one way to improve bone graft substitutes may be to engineer a synthetic matrix that is influenced by the physical appearance of natural ECM networks.In this work,the authors evaluate composite,hybrid scaffolds for bone tissue engineering based on composite ceramic/polymer microsphere scaffolds with synthetic ECM-mimetic networks in their pore spaces.Using thermally induced phase separation,nanoscale fibers were deposited in the pore spaces of structurally sound microsphere-based scaffold with a density proportionate to the initial polymer concentration.Porosimetry and mechanical testing indicated no significant changes in overall pore characteristics or mechanical integrity as a result of the fiber deposition process.These scaffolds displayed adequate mechanical integrity on the scale of human trabecular bone and supported the adhesion and proliferation of cultured mouse calvarial osteoblasts.Drawing from natural cues,these scaffolds may represent a new avenue forward for advanced bone tissue engineering scaffolds. | Clarke Nelson Yusuf Khan Cato T.Laurencin | 2014 | Regenerative Biomaterials2014，1，1： | 2 |
| 6 | Biodegradable polymers as biomaterials显示文摘 | Lakshmi S. Nair Cato T. Laurencin | 2007 | Progress in Polymer Science2007，，8： | 2 |
| 7 | Electrospun nanofibrous structure:a novel scaffold for tissue engineering显示文摘 | Li Wan-Ju Cato TL Edward JC | 2002 | Journal of Biomedical Materials Research2002，60，4： | 1 |
| 8 | Logic model: a tool for planning and evaluating health and recreation prevention projects显示文摘 | Cato B Chen W Corbett - Perez S | 1998 | Journal of Physical Education Recreation & Dance1998，69，8： | 1 |
| 9 | Measurement of lipoxygenase in Australian white wheat flour:the effect of lipoxygenase on the quality properties of white salted noodles显示文摘 | Cato Larisa halmos Andrew L Small Darryl M | 2006 | Journal of the Science of Food2006，86，11： | 1 |
| 10 | Biodegradable polymers as biomaterials 显示文摘 | Lakshmi S N Cato T L | 2007 | Prog Polym Sci2007，32，： | 1 |
| 11 | Imposex in Whelks( Buccinum Undatum )from the Open North Sea: Relation to Shipping Traffic Intensities显示文摘 | Cato C Ten | 1994 | Marine Pollution Bulletin1994，28，05： | 1 |
| 12 | Rapid actions of steroid receptors in cellular signalling pathways显示文摘 | Cato AC Nestl A Mink S | 2002 | Sci STKE2002，138，： | 1 |
| 13 | Ant algorithms for discrete optimization显示文摘 | Dorigo M Cato G D Gambardella L M | 1999 | Artificial Life1999，5，2： | 1 |
| 14 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 15 | The sequestration sink of soot black carbon in the Northern European Shelf sediments显示文摘 | Sánchez-García Laura Cato Ingemar Gustafsson ?rjan | 2012 | EN2012，，1： | 1 |
| 16 | AngiotensinⅡexcites paraventricular nucleus neurons that innervate the rostral ventrolateral medulla an in vitro patch-clamp study in brain slices显示文摘 | Cato M J Toney G M | 2005 | J Neurophysiol2005，93，1： | 1 |
| 17 | Effect of nitrogen compounds on cracking catalysts 显示文摘 | HO Teh C KATRITZKY Alan R CATO Stephen J | 1992 | Ind Eng Chem Res1992，31，7： | 1 |
| 18 | Retrovirus mediated IL 4 gene therapy inspontaneous adenocarcinoma from MMTV neutransgenic mice显示文摘 | Sacco M Benedetti S Cato EM | 1999 | Gene Ther1999，6，11： | 1 |
| 19 | Freeman, Ligament tissue engineering: An evolutionary materials science approach显示文摘 | Cato T Laurencin Joseph W | 2005 | Biomaterials2005，26，： | 1 |
| 20 | The hormone response element of the mouse mammary tumor virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat resion显示文摘 | Cato ACB Henderson D Ponta H | 1987 | EMBO J1987，6，： | 1 |
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