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| 1 | Vitamin D status and viral response to therapy in hepatitis C infected children显示文摘AIM: To study the frequency of vitamin D deficiency in patients with hepatitis C virus(HCV) infection and to evaluate the role of vitamin D supplementation in improving antiviral therapy.METHODS: Sixty-six children aged from 7-14 years(mean ± SD, 11.17 ± 2.293) diagnosed with HCV infection were matched to 28 healthy controls. Serum levels of 25(OH) D3, calcium, phosphorus, alkaline phosphatase and plasma level of parathormone were measured. Quantitative PCR for HCV was performed Bone density was determined by dual energy X-ray absorptiometry. All cases received conventional therapy, and only 33 patients received vitamin D supplementation.RESULTS: Children with HCV showed significantly increased levels of HCV RNA(P < 0.001), parathormone(P < 0.01) and decreased vitamin D levels(P < 0.05)(33.3% deficient and 43.3% insufficient) compared with controls. Abnormal bone status(Z score-1.98 ± 0.75) was found in ribs, L-spine, pelvis and total body. Cases treated with vitamin D showed significant higher early(P < 0.04) and sustained(P < 0.05) virological response. There was a high frequency of vitamin D deficiency among the Egyptian HCV children, with significant decrease in bone density. The vitamin D level should be assessed before the start of antiviral treatment with the correction of any detected deficiency. CONCLUSION: Adding vitamin D to conventional Peg/RBV therapy significantly improved the virological response and helped to prevent the risk of emerging bone fragility. | Azza A Eltayeb Madleen Adel A Abdou Amal M Abdel-aal Mostafa H Othman | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 2 | Collected rainfall as a water source in Danish households-What is the poten2tial and what are the costs显示文摘 | Mikkelsen P S Adeler O F Albrechtsen H J | 1999 | Wat Res&Tech1999，39，5： | 1 |
| 3 | Modeling of zinc bromide energy storage for vehicular applications 显示文摘 | EMAD M ADEL N RENTEL C H | 2010 | IEEE Transactions on Industrial Electronics2010，57，2： | 1 |
| 4 | Decreased tumor cell proliferation as an indicator of the effect of preoperative ra- diotherapy of rectal cancer 显示文摘 | Adell G Zhang H Jansson A | 2001 | Int J Radiat Oncol Biol Phys2001，50，3： | 1 |
| 5 | Ultimate bearing capacity of triangular shell strip footings on sand 显示文摘 | Adel H Mohanmed A E | 1990 | Journal of Geotechnical Engineering1990，116，12： | 1 |
| 6 | Mechanical vapor compression desalination systems-a case study 显示文摘 | Narmine H Aly Adel K El-Fiqi | 2003 | Desalination2003，158，13： | 1 |
| 7 | Carboxymethylated cellulose hydrogel;sorption behavior and characterization显示文摘 | Adel A M Abou-Youssef H El-Gendy A A | 2010 | Nature and Science2010，8，8： | 1 |
| 8 | Metabolism of gentiopicroside (gentiopicrin) by human intestinal bacteria 显示文摘 | Adel I E S Masao H Kyoichi K | 1989 | Chem Pharm Bull1989，37，9： | 1 |
| 9 | Influenza a viral infection associated with acute renal failure显示文摘 | ADEL S FRED E H | 1976 | Am J Med1976，61，5： | 1 |
| 10 | Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations显示文摘 | Adele H Jane S Helen T | 2001 | Blood2001，97，： | 1 |
| 11 | Determination of the Best Coverage Area for Receiver Stations of LEO Remote Sensing Satellites显示文摘 | Leila M Nader M Adel H | 2008 | ICTTA2008，，： | 1 |
| 12 | Regularization neural network for construction cost estimation显示文摘 | Adell H Wu M | 1998 | Journal of Construction Engineering and Management1998，124，1： | 1 |
| 13 | Metabolism of swer tiamarin from Swertia japonica by human intestinal bacteria 显示文摘 | Adel I E S Shu Y Z Masao H | 1988 | Planta Medica1988，55，： | 1 |
| 14 | Force on single piles in clay subjected to surcharge loading显示文摘 | ADEL M H ALI S D | 2006 | International journal of geomechanics2006，6，2： | 1 |
| 15 | The effect of food on the oral bioavailability and the pharacodynamic actions of the insulinotropic agent nateglinide in healthy subjects显示文摘 | Beth E Dunning James F Mcleod | 1999 | J Clin Pharmacol1999，39，： | 1 |
| 16 | Do visual analoguescale(VAS)derived standard gamble(SG)utilities agree with HealthUtilities Index utilities? A comparison of patient and community pref-erences for health status in rheumatoid arthritis patients显示文摘 | Amir Adel RashiditAslam H Anis Carlo A Marra | 2006 | Healthand Quality of Life Outcomes2006，25，： | 1 |
| 17 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 18 | PTFlalpha/p48 transcription factor couples proliferation and differentiation in the exocrine pancreas 显示文摘 | Rodolosse A Chalaux E Adell T Hagege H Skoudy A Real FX | 2004 | Gastroenterology2004，127，3： | 1 |
| 19 | Soil seed banks in the Aras-baran Protected Area of Iran and their significance for conservationmanagement显示文摘 | Adel J Behnam H Younes A | 2003 | Biological Conservation2003，109，3： | 1 |
| 20 | Significance Of Cox-2 expression in rectal cancers with or without preoperative radiotherapy 显示文摘 | Pachkoria K Zhang H Adell G | 2005 | Int J Radiat Oncol Biol Phys2005，63，3： | 1 |
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