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| 1 | Bone graft substitutes for spine fusion: A brief review显示文摘Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins(recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice. | Ashim Gupta Nitin Kukkar Kevin Sharif Benjamin J Main Christine E Albers Saadiq F El-Amin Ⅲ | 2015 | World Journal of Orthopedics2015，6，6： | 4 |
| 2 | Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone显示文摘 | Saadiq F El-Amin Mohamed Attawia Helen H Lu Asist K Shah Richard Chang Noreen J Hickok Rocky S Tuan Cato T Laurencin | 2002 | Journal of Orthopaedic Research2002，，1： | 1 |
| 3 | Three-dimensional,bioactive,biodegradable,polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human oste-oblast-like cells in vitro显示文摘 | HELEN H L SAADIQ F E KIMBERLI D S | 2003 | J Biomed Mater Res A2003，64，3： | 1 |
| 4 | Three-dimensional,bioactive,biodegradable,polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro显示文摘 | Saadiq F E Kimberli D S | 2003 | J B iomed Mater Res (A)2003，64，3： | 1 |
| 5 | The Biocompatibility of Biodegradable Glycine Containing Polyphosphazenes: A Comparative study in Bone显示文摘 | Saadiq F. El-Amin Michael S. Kwon Trevor Starnes Harry R. Allcock Cato T. Laurencin | 2006 | Journal of Inorganic and Organometallic Polymers and Materials2006，，4： | 1 |
| 6 | Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone显示文摘 | Saadiq F EI-Amin Mohamed A | 2002 | Journal of Orthopaedic Research2002，20，： | 1 |
| 7 | An Efficient Procedure for DNA Isolation and Profiling of the Hyper Variable MtDNA Sequences显示文摘 | Nazia Akbar Habib Ahmad Muhammad Shahid Nadeen Nasir Ali Muhammad Saadiq | 2015 | Journal of Life Sciences2015，9，11： | 0 |
| 8 | 肾血管性高血压诱导代谢综合征猪的心肌线粒体损伤,导致心脏损伤和功能障碍显示文摘肾血管性高血压(renovascular hypertension,RVH)患者常常也并发代谢综合征(metabolic syn-drome,Met S)。Met S和高血压并存增加心血管病的发病率和死亡率,但是心脏损伤的潜在机制仍不清楚。本研究假设合并Met S可引发RVH猪心肌线粒体损伤,导致心脏损伤和功能障碍。方法:经过16周喂食诱导合并或不合并RVH(单侧肾动脉狭窄)的实验猪患MetS,瘦猪(Lean)作为对照组,每组6只。 | Nargesi AA Farah MC Zhu XY Zhang L Tang H Jordan KL Saadiq IM Lerman A Lerman LO Eirin A 袁源(翻译) 周卫(翻译) | 2022 | 中华高血压杂志2022，30，3： | 0 |
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