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| 1 | Current state of renal transplant immunosuppression:Present and future显示文摘For kidney transplant recipients, immunosuppression commonly consists of combination treatment with a calcineurin inhibitor, an antiproliferative agent and a corticosteroid. Many medical centers use a sequential immunosuppression regimen where an induction agent, either an anti-thymocyte globulin or interleukin-2 receptor antibody, is given at the time of transplantation to prevent early acute rejection which is then followed by a triple immunosuppressive maintenance regimen. Very low rejection rates have been achieved at many transplant centers using combinations of these agents in a variety of protocols. Yet, a large number of recipients suffer chronic allograft injury and adverse events associated with drug therapy. Regimens designed to limit or eliminate calcineurin inhibitors and/or corticosteroid use are actively being pursued. An ideal immunosuppressive regimen limits toxicity and prolongs the functional life of the graft. This article contains a critical analysis of clinical data on currently available immuno-suppressive strategies and an overview of therapeutic moieties in development. | Hari Varun Kalluri Karen L Hardinger | 2012 | World Journal of Transplantation2012，2，4： | 5 |
| 2 | Novel immunosuppressive agents in kidney transplantation显示文摘Excellent outcomes have been achieved in the field of renal transplantation. A significant reduction in acute rejection has been attained at many renal transplant centers using contemporary immunosuppressive, consisting of an induction agent, a calcineurin inhibitor, an antiproliferative agent plus or minus a corticosteroid. Despite improvements with these regimens, chronic allograft injury and adverse events still persist. The perfect immunosuppressive regimen would limit or eliminate calcineurin inhibitors and/or corticosteroid toxicity while providing enhanced allograft outcomes. Potential improvements to the calcineurin inhibitor class include a prolonged release tacrolimus formulation and voclosporin, a cyclosporine analog. Belatacept has shown promise as an agent to replace calcineurin inhibitors. A novel, fully-human anti-CD40 monoclonal antibody, ASKP1240, is currently enrolling patients in phase 2 trials with calcineurin minimization and avoidance regimens. Another future goal of transplant immunosuppression is effective and safe treatment of allograft rejection. Novel treatments for antibody mediated rejection include bortezomib and eculizumab. Several investigational agents are no longer being pursed in transplantation including the induction agents, efalizumab and alefacept, and maintenance agents, sotrastaurin and tofacitinib. The purpose of this review is to consolidate the published evidence of the effectiveness and safety of investigational immunosuppressive agents in renal transplant recipients. | Karen L Hardinger Daniel C Brennan | 2013 | World Journal of Transplantation2013，3，4： | 3 |
| 3 | Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice显示文摘 | Seiichi Oyadomari Heather P. Harding Yuhong Zhang Miho Oyadomari David Ron | 2008 | Cell Metabolism2008，，6： | 2 |
| 4 | The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines显示文摘 | Gary G. Adams Shahwar Imran Sheng Wang Abubaker Mohammad Samil Kok David A. Gray Guy A. Channell Gordon A. Morris Stephen E. Harding | 2011 | Food Research International2011，，4： | 2 |
| 5 | Oxygen desaturation during sleep in hepatopulmonary syndrome显示文摘 | David T. Palma George M. Philips Miguel R. Arguedas Susan M. Harding Michael B. Fallon | 2008 | Hepatology2008，，4： | 2 |
| 6 | A comparison of two business cycle dating methods显示文摘 | Don Harding Adrian Pagan | 2002 | Journal of Economic Dynamics and Control2002，，9： | 2 |
| 7 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 8 | Ranibizumab versus Bevacizumab to Treat Neovascular Age-related Macular Degeneration显示文摘 | Usha Chakravarthy Simon P. Harding Chris A. Rogers Susan M. Downes Andrew J. Lotery Sarah Wordsworth Barnaby C. Reeves | 2012 | Ophthalmology2012，，7： | 2 |
| 9 | Serum sickness aftertreatment with rabbit antjthymoeyte globulin in kidney transplant recipients with previous rabbit exposure显示文摘 | BOOTHPUR R HARDINGER K I SKELTON R M | 2010 | Am J Kidney Dis2010，55，1： | 1 |
| 10 | REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus显示文摘 | Christopher J Davis Joseph W Harding John W Wright | | 0，，02： | 1 |
| 11 | TheTragedyoftheCommons显示文摘 | HARDING | 1968 | Science1968，162，3859： | 1 |
| 12 | Biosynthesis of phytoene from isopenteny]pyrophosphate by a Neurospora enzyme system显示文摘 | Sprugeon SL Turner RV Harding RW | | 0，，01： | 1 |
| 13 | Light transmittance in forest canopies determined using airborne laser altimetry and in-canopy quantum measurements显示文摘 | Geoffrey G Parker Michael A Lefsky David J Harding | 2001 | Remote Sensing of Environment2001，，3： | 1 |
| 14 | Sirolimus Conversion in Liver Transplant Recipients With Renal Dysfunction: A Prospective, Randomized, Single-Center Trial显示文摘 | Surendra Shenoy Karen L. Hardinger Jeffrey Crippin Niraj Desai Kevin Korenblat Mauricio Lisker-Melman Jeffrey A. Lowell William Chapman | 2007 | Transplantation2007，，10： | 1 |
| 15 | The measurement of specimen surface temperature in high-speed tension and torsion tests显示文摘 | MACDOUGALL D HARDING J | | 0，，06： | 1 |
| 16 | Lidar Remote Sensing of the Canopy Structure and Biophysical Properties of Douglas-Fir Western Hemlock Forests显示文摘 | M.A. Lefsky W.B. Cohen S.A. Acker G.G. Parker T.A. Spies D. Harding | 1999 | Remote Sensing of Environment1999，，3： | 1 |
| 17 | GABA and Bicuculline-Induced Blood Pressure Changes in Spontaneously Hypertensive Rats显示文摘 | Kim A. Roberts John W. Wright Joseph W. Harding | 1993 | Journal of Cardiovascular Pharmacology1993，，1： | 1 |
| 18 | Photoregulation of the carote-noid biosynthesis pathway in albino and white collar mu-tants of Neurospora crassa显示文摘 | Harding R W Turner R V | | 0，，03： | 1 |
| 19 | Bacteria and wound healing显示文摘 | Edwards R Harding KG | | 0，，2： | 1 |
| 20 | Wound duration and healing rates: Cause or effect?显示文摘 | David C. Bosanquet Keith G. Harding | 2014 | Wound Repair Regen2014，，2： | 1 |
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