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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | 评估超高温灭菌奶安全和质量的2个重要参数显示文摘使用了一套电子程序表格,用于评估在连续热交换器中经过不同升温和降温处理后牛奶的安全和质量参数。安全参数包括致死率F0值、微生物灭活B*值;质量参数包括化学变化C*值、硫胺素损失量、乳果糖生成量、美拉德褐变及羟甲基糠醛值等。在牛奶中试加工车间中,利用升温和降温的温度变化数值可对牛奶的上述参数进行预测,温度范围为120~150℃,时间包括4、27和58 s。在同一中试车间按上述条件对牛奶进行加工,并选择一系列牛奶样品对该电子程序进行校正。结果表明,所有C*〈3的牛奶样品阿沙芬堡浊度都呈阳性。在乳果糖活化能等于122 k J/mol时,预测值和试验观测值一致性最好。最佳质量终产品对应的牛奶加工条件为135℃/10 s,此时B*=1.24,C*=0.55。在此条件下加工的牛奶与其它2个牛奶相比,感官特性与C*=1.5对应条件下加工的牛奶类似,但与C*=6对应条件下加工的牛奶不同。牛奶刚加工完成时,仅热处理非常强烈的样品有可见的褐变,若在≥30℃条件下存储,褐变会变得比较明显。该电子程序可以用来比较不同热处理模式下生产产品的特性;或作为一种手段,用于在升温和降温速率固定的情况下UHT设备运行条件的优化。 | 陈美霞 Browning E Lewis M Macdougall D | 2016 | 中国乳业2016，，5： | 3 |
| 3 | Efficacy of Linaclotide for Patients With Chronic Constipation显示文摘 | Anthony J. Lembo Caroline B. Kurtz James E. MacDougall B.J. Lavins Mark G. Currie Donald A. Fitch Brenda I. Jeglinski Jeffrey M. Johnston | 2010 | Gastroenterology2010，，3： | 3 |
| 4 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 5 | Guideline for the laboratory diagnosis of functional iron deficiency显示文摘 | D. Wayne Thomas Rod F. Hinchliffe Carol Briggs Iain C. Macdougall Tim Littlewood Ivor Cavill | 2013 | Br J Haematol2013，，5： | 2 |
| 6 | 儿科PET/CT的操作和剂量学显示文摘在儿科PET/CT诊疗领域,迄今还没有统一的CT扫描方法的指南。考虑到儿童更易受电离辐射的影响,在最短时间内和最小暴露剂量条件下提供具有诊断质量的图像十分必要。该文描述了CT辐射剂量测定以及儿童PET/CT采集的基本要点。根据对北美19所儿科PET/CT机构的调查,描述了儿科PET/CT技术的多样性。调查结果表明,尽管大多数机构采用自动管电流调制,但在实际应用中各机构间仍存在2~3倍的差异,这说明需要统一的指南。该文介绍了作者所在机构研发的多序列PET/CT采集技术,此技术可以兼顾在重要部位视野内获得有诊断质量的CT图像,以及在其余部位应用低辐射技术进行显像。这种方法使患者所受辐射剂量减少,同时将PET和具有诊断质量的CT集成在单次采集中。儿科PET/CT的标准化在保证适中水平的图像质量的同时,为患者提供了减少辐射剂量的机会。 | 王宽垠(译) 刘振(译) 兰晓莉(审校) Frederic H. Fahey Alison Goodkind Robert D. MacDougall Leah Oberg Sonja I.Ziniel Richard Cappock Michael J. Callahan Neha Kwatra S. Ted Treves Stephan D. Voss | 2019 | 中华核医学与分子影像杂志2019，39，5： | 2 |
| 7 | Measuring episodic abdominal pain and disability in suspected sphincter of Oddi dysfunction显示文摘AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction(SOD).METHODS:Although several treatments have been utilized to reduce pain and associated disability,measurement tools have not been developed to reliably track outcomes.Two pilot studies were conducted to assess test-retest reliability of a newly developed instrument,the recurrent abdominal pain intensity and disability(RAPID) instrument.The RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes,and is modeled after the migraine disability assessment instrument used to measure headache-related disability.RAPID was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD:a pre-sphincterotomy population(Pilot Ⅰ,n = 55) and a post-sphincterotomy population(Pilot Ⅱ,n = 70).RESULTS:The average RAPID scores for Pilots Ⅰ and Ⅱ were:82 d(median:81.5 d,SD:64 d) and 48 d(median:0 d,SD:91 d),respectively.The concordance between the 2 assessments for both populations was very good:0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy population.CONCLUSION:The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients. | Valerie Durkalski Walter Stewart Paulette MacDougall Patrick Mauldin Joseph Romagnuolo Olga Brawman-Minzter Peter Cotton | 2010 | World Journal of Gastroenterology2010，16，35： | 2 |
| 8 | The effectiveness of case-based learning in health professional education. A BEME systematic review: BEME Guide No. 23显示文摘 | Jill Elizabeth Thistlethwaite David Davies Samilia Ekeocha Jane M. Kidd Colin MacDougall Paul Matthews Judith Purkis Diane Clay | 2012 | Medical Teacher2012，，6： | 2 |
| 9 | Erythropoietins: a common mechanism of action显示文摘 | Elliott S Pham E Macdougall IC | 2008 | Exp Hematol2008，36，12： | 1 |
| 10 | Erythropoietin resistance: the role of inflammation and pro -inflammatory cytokines 显示文摘 | Macdougall IC Cooper AC | 2002 | Nephrol Dial Transplant2002，17，11： | 1 |
| 11 | Skeletal Muscle Adaptations to Training under Normobaric Hypoxic Versus Normoxic Conditions显示文摘 | MELISSA L MACDOUGALL J D TARNOPOLSKY M A | 1997 | Med Sci Sports Exe1997，，29： | 1 |
| 12 | Study of the mechanism of the vanadium 4+/5+ redox reaction in acidic solutions显示文摘 | Gattrell M Park J MacDougall B | 2004 | J Electrochem Soc2004，151，： | 1 |
| 13 | Mariana Trough basalts (MTB):Trace element and Sr-Nd isotopic evidence for mixing between MORB-like and arc-like melts显示文摘 | VOLPE A M MACDOUGALL J D HAWKINS J W | 1987 | Earth and Planetary Science Letters1987，82，： | 1 |
| 14 | The Benefits and Costs of Private Investment from Abroad: A Theoretical Approach 显示文摘 | MACDOUGALL | 1960 | Economic Record1960，36，： | 1 |
| 15 | Efficacy of linaclotide for patients with chronic constipation显示文摘 | Lembo AJ Kurtz CB Macdougall JE | 2010 | Gastroenterology2010，138，3： | 1 |
| 16 | Is early treatment of anaemia with epoetin-alpha beneficial to pre-dialysis chronic kidney disease patients? Results of a multicentre, open-label, prospective, randomized, comparati ve group t r i al显示文摘 | Macdougall IC Temple RM Kwan Jr | 2007 | Nephrol Dial Transplant2007，22，3： | 1 |
| 17 | Capacitors显示文摘 | SARJEANT W J ZIRNHELD J MACDOUGALL F W | 1998 | IEEE Transactions on Plasma Science1998，26，5： | 1 |
| 18 | Ameloblastin gene (AMBN) maps within the critical region for autosomal dominant amelogenesis imperfecta at chromosome 4q21 显示文摘 | DuPont BR Simmons D | 1997 | Genomics1997，41，： | 1 |
| 19 | The benefits and costs of private investment from abroad : a theoretical approach显示文摘 | MACDOUGALL G | 1960 | Economic Record1960，36，2： | 1 |
| 20 | Early recurrent ischemic stroke complicating intravenous thrombolysis for stroke:incidence and association with atrial fibrillation显示文摘 | Awadh M MacDougall N Santosh C | 2010 | Stroke2010，41，： | 1 |
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