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| 1 | 白内障药物治疗的研究现状显示文摘白内障的药物治疗仍然面临着严峻的挑战。尽管近 40多种抗白内障药物被广泛的临床使用 ,但证明其有效性的直接证据甚少。醛糖还原酶抑制剂 (ARIs)的副作用严重 ,药物机制“名不符实” ;阿司匹林类药物廉价方便 ,副作用少 ,有望达到预期的效果 ;维生素类抗氧化剂的预防和治疗白内障的作用有限 ,临床资料缺乏可比性 ;糖基化抑制剂 ,谷胱甘肽和药物前体 ,相分离抑制剂和Calpain抑制剂等的研究有较大的进展 ,需要临床研究的进一步验证。可能有效的药物治疗白内障的手段仍将是联合用药的方法。 | 严宏 李明勇 Harding JJ | 2002 | 国外医学(眼科学分册)2002，26，3： | 10 |
| 2 | Inactivation and loss of antigenicity of ester- ase by sugars and a steroid显示文摘 | Yan H Harding JJ | 1999 | Biochim Biophys Acta1999，1454，2： | 1 |
| 3 | Revival of inactive glyceraldehyde 3-phosphate dehydrogenase in human cataract lenses by reduction 显示文摘 | Rachdana D Lou MF Harding JJ | 2004 | Exp Eye Res2004，79，1： | 1 |
| 4 | α-Crystallin as a molecular chaperone 显示文摘 | Derham BK Harding JJ | 1999 | Prog Retina Eye Res1999，18，4： | 1 |
| 5 | The relationship of BRMS1 and RhoGD12 gene expression to metastatic potential in lineage related human bladder cancer cell lines 显示文摘 | Seraj MJ Harding MA Gildea JJ | 2001 | Clin Exp Metastasis2001，18，6： | 1 |
| 6 | Aspirin and cataract 显示文摘 | Harding JJ | 1999 | Ophthalmology1999，106，12： | 1 |
| 7 | Estrogens and cataract显示文摘 | Harding JJ | 1994 | Arch Ophthaimol1994，112，12： | 1 |
| 8 | Alpha-crystallin as a molecular chaperone显示文摘 | Derham BK Harding JJ | 1999 | Prog Retin Eye Res1999，18，： | 1 |
| 9 | UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy显示文摘 | Turner JJ Stacey JM Harding B | 2003 | J Clin Endocrinol Metab2003，88，3： | 1 |
| 10 | The decreased chaperone activity of α-crystallin in selenite cataract may result from selenite-induced aggregation显示文摘 | Yan H Harding JJ Hui YN | 2003 | Eye2003，17，： | 1 |
| 11 | Effects of modifications of α-crystallin on its chaperone and other properties显示文摘 | Derham B Harding JJ | 2002 | Biochem J2002，364，： | 1 |
| 12 | The relationship of BRMSl and RhoGDI gene expression to metastatic potential in lineage related human bladder cancer cell lines显示文摘 | Seraj M J Harding MA Gildea JJ | 2000 | Clin Exp Metastasis2000，15，6： | 1 |
| 13 | Viewing molecular mechanisms of ageing through a lens显示文摘 | Harding JJ | 2002 | Ageing Research Reviews2002，1，3： | 1 |
| 14 | Viewing molecular mechanisms of ageing through a lens 显示文摘 | Harding JJ | 2002 | Ageing Res Rev2002，1，： | 1 |
| 15 | The role of Ral A in epidermal growth factor receptor-regulated cell motility显示文摘 | Gildea JJ Harding MA Seraj MJ | 2002 | Cancer Res2002，62，： | 1 |
| 16 | Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase,in conjunction with alpha-crystallin or thioltransferase 显示文摘 | Yan H Harding JJ Xing K | 2007 | Curr Eye Res2007，32，： | 1 |
| 17 | Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase 显示文摘 | Yan H Harding JJ | 1997 | Biochem J1997，328，： | 1 |
| 18 | The reaction of methylglyoxal with human and bovine lensproteins显示文摘 | RILEY ML HARDING JJ | 1995 | Biochim Biophys Acta1995，1270，1： | 1 |
| 19 | Inactivation and loss of antigenicity of esterase by sugars and a steroid 显示文摘 | Yan H Harding JJ | 1999 | Biochim Biophys Acta1999，1454，2： | 1 |
| 20 | The molecular chaperone, α-crystallin, protects against loss of antigenicity and activity of esterase caused by sugars, sugar phosphate and a steroid 显示文摘 | Yan H Harding JJ | 2003 | Biol Chem2003，384，8： | 1 |
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