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| 1 | High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection显示文摘AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori infection.METHODS: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify HBD-2.RESULTS: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected subjects.CONCLUSION: Our results place the β-defensins, especially HBD-2, in the front line of innate immune defence.Moreover, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. | Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya Hirayama Masamitsu Nakazato Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，31： | 10 |
| 2 | High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia 显示文摘 | Ide M Ishii H Mukae H | 2008 | Respir Med2008，102，11： | 1 |
| 3 | Elevation of tumor-associated carbohydrate antigens in patients with diffuse panbronchiolitis 显示文摘 | MUKAE H HIROTA M KOHNO S | 1993 | Am Rev Respir Dis1993，148，3： | 1 |
| 4 | The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow显示文摘 | MUKAE H VINCENT R QUINLAN K | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 5 | Elevated plasma pmcoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Med2002，41，： | 1 |
| 6 | Elevated levels of alpha-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis显示文摘 | Ashitani J Mukae H Hiratsuka T | 2002 | Chest2002，121，2： | 1 |
| 7 | Rapidly progressive interstitial pneumonia associated with clinic- ally amyopathic dermatomyositis successfully treated with polymyxin B-immobilized fiber column hemoperfusion显示文摘 | Kakugawa T Mukae H Saito M | 2008 | Intern Med2008，47，8： | 1 |
| 8 | Capacitance-vs-voltage characteristics of ZnO varistors 显示文摘 | Mukae K Tsuda K Nagasawa I | 1979 | J Appl Phys1979，50，6： | 1 |
| 9 | Elevated levels of a-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis显示文摘 | Ashitani J Mukae H Hiratsuka T | 2002 | Chest2002，121，2： | 1 |
| 10 | The effects of dopamine,dobutamine and amrinone on mitochondrial function in cardiogenic shock显示文摘 | Mukae S Yanagishita T Geshi E | 1997 | Jpn Heart J1997，38，4： | 1 |
| 11 | Increased expression of collagen - binding heat shock protein 47 in murine bleomycin - induced pneumopathy 显示文摘 | Ishii H Mukae H Kakugawa T | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，4： | 1 |
| 12 | Effect of Erythromycin on Chronic Respiratory Infection Caused by Pseudomonas aeruginosa with Biofilm Formation in an Experimental Murine Model显示文摘 | Nagata T Mukae H Kadota J | 2004 | Antimicrohial Agents and Chemotherapy2004，48，6： | 1 |
| 13 | Swelling of poly(N-isopropylacrylamide) gels in water-alcohol (C1-C4) mixed solvents 显示文摘 | Mukae K Sakurai M Sawamura S | 1993 | The Journal of Physical Chemistry1993，97，3： | 1 |
| 14 | Elevated plasma procoagulant and fibrino lyticmarkers in patients with chronic obstructive pulmonary disease 显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Med2002，41，3： | 1 |
| 15 | FJevated plasma procoagu- lant and fibrinolytic markers in patients with chronic obstructive pulmonary disease显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Med2002，41，3： | 1 |
| 16 | Zinc oxide varistors with praseodymium oxide显示文摘 | Mukae K | | 0，，： | 1 |
| 17 | Elevated plasma pro-coagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Med2002，41，3： | 1 |
| 18 | Pirfenidone inhibits TGF- 131-induced over-expression of collagen type I and heat shock protein 47 in A549 cells显示文摘 | Hisatomi K Mukae H Sakamoto N | 2012 | BMC Pulm Med2012，12，： | 1 |
| 19 | Zinc oxide-praseodymium oxide elements for surge arresters显示文摘 | Mukae K Tsuda K Shiga S | | 0，，： | 1 |
| 20 | Elevated plasma procoagnlaunt and fibrinolytie markers in patients with chronic obstructive pulmonary disease显示文摘 | Ashitani J Mukae H Arimura Y | 2002 | Intern Meal2002，41，： | 1 |
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