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| 1 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 2 | 铁在气氛中渗碳、脱碳及氮化、脱氮时其表面反应的动力学和机理显示文摘本文论述了铁在渗碳和脱碳及氮化和脱氮过程中其表面发生的具有意义的最主要反应的动力学和机理,给出了纯铁表面发生这些反应的动力值,探讨了各种反应速度的计算方法及反应过程中原子运动机理。 | HansJürgenGrabke 江先雄 | 1990 | 国外金属热处理1990，11，1： | 3 |
| 3 | Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic Esophagitis显示文摘 | Alex Straumann Sebastien Conus Lukas Degen Stephanie Felder Mirjam Kummer Hansjürg Engel Christian Bussmann Christoph Beglinger Alain Schoepfer Hans–Uwe Simon | 2010 | Gastroenterology2010，，： | 2 |
| 4 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 5 | Chemistry and biology of thiamethoxam: a second generation neonicotinoid显示文摘 | PeterMaienfisch MaxAngst FranzBrandl WilliFischer DieterHofer HartmutKayser WernerKobel AlfredRindlisbacher RobertSenn AdrianSteinemann HansjürgWidmer | 2001 | Pest Manag Sci2001，，10： | 2 |
| 6 | Benign Liver Tumors: Differential Diagnosis and Indications for Surgery显示文摘 | Arved Weimann Burckhardt Ringe Jürgen Klempnauer Peter Lamesch Klaus F. Gratz Mathias Prokop Hansj?rg Maschek Günter Tusch Rudolf Pichlmayr | 1997 | World Journal of Surgery1997，，9： | 2 |
| 7 | Ruin theory with excess of loss reinsurance and reinstatements显示文摘 | Hansj(o)rg Albrecher Sandra Haas | | 0，，20： | 1 |
| 8 | Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson’s disease (preclinical and clinical stages)显示文摘 | Heiko Braak Kelly Del Tredici Hansjürgen Bratzke John Hamm-Clement Daniele Sandmann-Keil Udo Rüb | 2002 | Journal of Neurology2002，，3： | 1 |
| 9 | Associationsa mongoxidized low density lipoprotein antibody,Creactive protein,interleukin-6,and circulating ceadhesion moleculesin patients with unstable anginpectoris显示文摘 | DooYC HanSJ LeeJH | 2004 | Am J Cardiol2004，93，： | 1 |
| 10 | Integrating molecular information into treatment of childhood acute lymphoblastic leukemia—A perspective from the BFM Study Group显示文摘 | Martin Stanulla Gunnar Cario Barbara Meissner André Schrauder Anja M?ricke Hansj?rg Riehm Martin Schrappe | 2007 | Blood Cells Molecules and Diseases2007，，2： | 1 |
| 11 | Microgliaand centralnervous system immunity显示文摘 | KaurG HanSJ YangI | | 0，，01： | 1 |
| 12 | Integrating molecular information into treatment of childhood acute lymphoblastic leukemia—A perspective from the BFM Study Group显示文摘 | Martin Stanulla Gunnar Cario Barbara Meissner André Schrauder Anja M?ricke Hansj?rg Riehm Martin Schrappe | 2007 | Blood Cells Molecules and Diseases2007，，2： | 1 |
| 13 | Associations among oxidized low- density lipoprotein antibody, C - reactive protein, interleukin - 6, and circulating cell adhesion molecules in patients with unstable angina pectoris 显示文摘 | Doo YC HanSJ LeeJH etal | 2004 | AmJ Cardiol2004，93，5： | 1 |
| 14 | PosteriorcirculationischemicstrokeinKoreanpopulation 显示文摘 | LeeJH HanSJ YunYH etal | 2006 | EurJNeurol2006，13，7： | 1 |
| 15 | Benign Liver Tumors: Differential Diagnosis and Indications for Surgery显示文摘 | Arved Weimann Burckhardt Ringe Jürgen Klempnauer Peter Lamesch Klaus F. Gratz Mathias Prokop Hansj?rg Maschek Günter Tusch Rudolf Pichlmayr | 1997 | World Journal of Surgery1997，，9： | 1 |
| 16 | Image-guided radiofrequency ablation of hepatocellular carcinoma (HCC): Is MR guidance more effective than CT guidance?显示文摘 | Stephan Clasen Hansj?rg Rempp Rüdiger Hoffmann Hansj?rg Graf Philippe L. Pereira Claus D. Claussen | 2014 | European Journal of Radiology2014，，1： | 1 |
| 17 | Innovation Networks in Eastern Germany: A Still Underutilised Potential for Human Cap!tal Formation in the Region 显示文摘 | SOETE B1RGIT WURZEL ULRICH G DREWELLO HANSJ? RG | 2002 | Economic Bulletin2002，39，5： | 1 |
| 18 | Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice显示文摘 | Philip Maier Anke S. Unsoeld Bernd Junker Gottfried Martin Joachim Drevs Lutz L. Hansen Hansjürgen T. Agostini | 2005 | Graefe’s Archive for Clinical and Experimental Ophthalmology2005，，6： | 1 |
| 19 | An asymptotical study of combinatorial optimization problems by means of statistical mechanics显示文摘 | Albrecher Hansj?rg Burkard Rainer E Cela Eranda | 2005 | Journal of Computational and Applied Mathematics2005，68，3： | 1 |
| 20 | Prolonged Antibiotic Prophylaxis in Patients with Bilioenteric Anastomosis Undergoing Percutaneous Radiofrequency Ablation显示文摘 | Rüdiger Hoffmann Hansj?rg Rempp Diethard Schmidt Philippe L. Pereira Claus D. Claussen Stephan Clasen | 2012 | Journal of Vascular and Interventional Radiology2012，，4： | 1 |
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