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| 1 | Species-specific Response of Photosynthesis to Burning and Nitrogen Fertilization显示文摘The present study was conducted to examine photosynthetic characteristics of three dominant grass species (Agropyron cristatum,Leymus chinensis,and Cleistogenes squarrosa) and their responses to burning and nitrogen fertilization in a semiarid grassland in northern China. Photosynthetic rate (Pn),stomatal conductance (gs),and water use efficiency (WUE) showed strong temporal variability over the growing season. C. squarrosa showed a significantly higher Pn and WUE than A. cristatum and L. chinensis. Burning stimulated Pn of A. cristatum and L. chinensis by 24–59% (P < 0.05) in the early growing season,but not during other time periods. Light-saturated photosynthetic rate (Pmax) in A. cristatum and the maximum apparent quantum yield (Φmax) in A. cristatum and L. chinensis were significantly enhanced by burning (16–67%) in both the fertilized and unfertilized plots. The main effect of burning on Pn,Pmax and Φmax was not significant in C. squarrosa. The burning-induced changes in soil moisture could explain 51% (P =0.01) of the burning-induced changes in Pn of the three species. All three species showed positive responses to N fertilization in terms of Pn,Pmax,and Φmax. The stimulation of Pn under N fertilization was mainly observed in the early growing season when the soil extractable N content was significantly higher in the fertilized plots. The N fertilization-induced changes in soil extractable N content could explain 66% (P = 0.001) of the changes in Pn under N fertilization. The photosynthetic responses of the three species indicate that burning and N fertilization will potentially change the community structure and ecosystem productivity in the semiarid grasslands of northern China. | Yanfang Zhang Shuli Niu Wenhua Xu Yi Han | 2008 | Journal of Integrative Plant Biology2008，50，5： | 8 |
| 2 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 3 | Inflammation-induced CD69^+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1显示文摘Kupffer cells,tissue-resident macrophage lineage cell,are enriched in vertebrate liver.The mouse F4/80^+ Kupffer cells have been subclassified into two subpopulations according to their phenotype and function:CD68^+ subpopulation with potent reactive oxygen species(ROS) production and phagocytic capacities,and CD11b^+ subpopulation with a potent capacity to produce T helper 1 cytokines.In addition,CD11b^+ Kupffer cells/macrophages may be migrated from the bone marrow or spleen,especially in inflammatory conditions of the liver.For analyzing diverse Kupffer cell subsets,we infected mice with Listeria monocytogenes and analyzed the phenotype variations of hepatic Kupffer cells.During L.monocytogenes infection,hepatic CD69^+ Kupffer cells were significantly induced and expanded,and CD69^+ Kupffer cells expressed higher level of CD11 b,and particularly high level of membrane-bound TGF-β1(mTGF-β1) but lower level of F4/80.We also found that clodronate liposome administration did not eliminate hepatic CD69^+ Kupffer cell subset.We consider the hepatic CD69^+ Kupffer cell population corresponds to CD11b^+Kupffer cells,the bone marrow-derived population.Hepatic CD69^+ Kupffer cells suppressed Ag-nonspecific and OVA-specific CD4 T cell proliferation through mTGF-β1 both in vitro and in vivo,meanwhile,they did not interfere with activation of CD4 T cells.Thus,we have identified a new subset of inflammation-induced CD69^+ Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-β1 at the late stage of immune response against infection.CD69^+ Kupffer cells may contribute to protect host from pathological injure by preventing overactivation of immune response. | Xiang Zhang Zhengping Jiang Yan Gu Yanfang Liu Xuetao Cao Yanmei Han | 2016 | Science China(Life Sciences)2016，59，12： | 5 |
| 4 | Chalkiness Characters and Scanning Electron Microscope Observation of Rice Grain Endosperm of Japonica Varieties in Southern Henan显示文摘Chalkiness characters affect not only the grain appearance,milling,eating and cooking qualities but also the grain nutritional quality in rice,thus it is one of the most important traits in rice. It is very important for us to investigate the relation of the chalkiness formation and the development of endosperm structure and starch granule of different rice varieties. Here,we have investigated the chalkiness characters such as chalkiness rate,chalkiness degree and chalkiness area in 15 japonica rice varieties from southern Henan. Furthermore,the endosperm structure and starch granules of rice grain were also observed with scanning electron microscope. The results showed that the 15 japonica varieties have a significantly linear relationship between the chalkiness rate and chalkiness degree. Among the varieties,the biggest difference is the chalkiness rate,the second is the chalkiness area,and the last is the chalkiness degree. Moreover,there is a certain correlation between the distribution of starch granules,the arrangement of endosperm cells and the occurrence of grain chalkiness in the different rice varieties. For the same variety,the starch granules of chalky and non-chalky grains have obvious difference,while the starch granules from the transparent part of chalky rice and non-chalky rice do not have significant difference. The results would provide useful references for the improvement of grain quality in rice. | Bo PENG Yanfang SUN Dongyan KONG Ruihua PANG Xiaohua SONG Huilong LI Jintao LI Qiying ZHOU Qiu HAN Shizhi SONG Hongyu YUAN | 2017 | Asian Agricultural Research2017，9，3： | 5 |
| 5 | Impact of biochar amendment on soil aggregation varied with incubation duration and biochar pyrolysis temperature显示文摘Soil aggregation is one of the crucial processes that facilitate carbon sequestration and maintain soil fertility.So far,the effect of biochar amendment on soil aggregation remains inconclusive.Here,we tested the hypothesis that the response of soil aggregation to biochar addition varied with incubation duration and biochar chemistry.A one year microcosm experiment of soil with biochar was conducted that included biochar produced at three different temperatures(300,450,and 600°C),and three biochar application rates,i.e.,0,1,and 3 wt%.It was observed that after one and three months,biochar mainly(>90%)distributed in the micro-aggregates,and slightly reduced aggregate stability and increased proportion of micro-aggregates,which was demonstrated to result from the mechanical mixture of amended biochar with soil.Contrastingly,when the duration was prolonged to six months and one year,a significant increase in macro-aggregates(6.6-38.5%)and aggregate stability(7.3-29.4%)was detected,with the increasing extent being apparently higher for low-temperature biochar.This was related to the comparatively strong interaction of biochar particles with soil minerals or microbes after long-time incubation.The strong interaction was directly supported by the significant increase in H/C,O/C ratios of isolated biochar from treated soils,the detection of typical soil mineral elements on the surface of isolated biochar,and the increase in microbial biomass carbon of treated soils.The findings of this study highlighted the role of biochar type and amendment duration in mediating the effect of biochar application on soil aggregation. | Lanfang Han Biao Zhang Liying Chen Yanfang Feng Yan Yang Ke Sun | 2021 | Biochar2021，3，3： | 4 |
| 6 | Structural Characterization of Glucan Produced by Lactobacillus sake L-7 from Sausage显示文摘A linear glucan was produced by Lactobacillus sake L-7 isolated from homemade sausage. Cultivation of the strain in Man–Rogosa–Sharpe(MRS) medium containing 50 g/L sucrose yielded 5.3 g/L of purified exopolysaccharide(EPS). The EPS was characterized by gas chromatography(GC), Fourier-transform infrared(FT-IR) spectroscopy, high-performance sizeexclusion chromatography(HPSEC), nuclear magnetic resonance(NMR) spectroscopy, and scanning electron microscopy(SEM). The monosaccharide composition of the EPS was glucose, and its molecular weight was 1 × 10~7 Da. The FT-IR and NMR spectra revealed that the L-7 EPS was a linear glucan with α-(1 → 6) glucosidic bonds. SEM images of the dried EPS revealed a hollow tubular structure. The water solubility index and water holding capacity of L-7 EPS were 96 and 272%, respectively. The results of hydrolysis indicated that L-7 EPS was not susceptible to hydrolysis by physiological barriers and can be used as a soluble dietary fiber with health benefits. All these characteristics suggest that L-7 EPS might have potential applications in the food, cosmetic, and pharmaceutical industries. | Fang Feng Qingqing Zhou Yanfang Yang Fangkun Zhao Renpeng Du Ye Han Zhijiang Zhou | 2019 | Transactions of Tianjin University2019，25，1： | 3 |
| 7 | Isolation, Purification, and Characterization of Exopolysaccharide Produced by Leuconostoc Citreum N21 from Dried Milk Cake显示文摘A strain with high production of exopolysaccharide(EPS) was isolated from dried milk cake(a traditional fermented food from Inner Mongolia). The strain was called N21 and later identified as Leuconostoc citreum( Leu. citreum). The strain was cultured in Man-Rogosa-Sharpe medium containing 50 g/L of sucrose for 48 h at 30 °C and the EPS purified, with a yield of 24.5 g/L. An average molecular weight of 6.07 × 10~6 g/mol was determined by high-performance size-exclusion chromatography. The structure of the purified EPS was investigated through gas chromatography, ~1H and ^(13)C nuclear magnetic resonance spectroscopy, and Fourier transform infrared spectroscopy. The results demonstrated a polysaccharide composed of D-glucopyranose units in a linear chain with consecutive α(1 → 6) linkages. No branching was found in the structure of the exopolysaccharide. The purified EPS showed high water solubility and emulsibility. Based on the thermogravimetric curve, the degradation temperature of the EPS was 308.47 °C, which suggested that the dextran in the study exhibited high thermal stability. The results indicated that Leu. citreum N21 could be widely used to produce linear EPS and that the EPS has potential applications in food science and processing as a food additive. | Yanfang Yang Fang Feng Qingqing Zhou Fangkun Zhao Renpeng Du Zhijiang Zhou Ye Han | 2019 | Transactions of Tianjin University2019，25，2： | 2 |
| 8 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 9 | Design of a Hydraulic Control Unit for a Two-Speed Dedicated Electric Vehicle Transmission显示文摘Two-speed automatic transmission is one solution to increase the economic efficiency and dynamic performance of battery electric vehicles(BEV).Hydraulic control unit(HCU)is a key component in automatic transmissions,which determines the quality of shifting directly.Based on the structural scheme and shift logic of a two-speed dedicated electric vehicles transmission(2DET)with two wet clutches,we designs a 2DET hydraulic control unit composed of three subsystems:pressure regulating and flow control system,shift operated and control system and cooling and lubrication system.The results of the experiments,including the valve body bench test,transmission bench test and vehicle test,show that the design of hydraulic control unit meets the requirements. | Xiangyang Xu Wenbo Sun Tianyuan Cai Yanfang Liu Xiao Han | 2018 | Automotive Innovation2018，1，4： | 2 |
| 10 | Isolation and Identification of Photobacterium damselae subsp.damselae(PDD) from Tongue Sole显示文摘In May 2016,an epizootic occured among cultured tongue soles caused mass deaths in a fish farm in Qinhuangdao,China.In order to find out the etiological agent,a bacterial strain was isolated from ascites and other tissues of sick tongue sole aseptically collected.The isolate was identified as Photobacterium damselae subsp.damsela(PDD) by isolation culture,Gram staining,physiological identification,morohological observation,biochemical identification and 16S rDNA sequence analysis.The results showed that the isolate shared 99.6% homology with the reference strain in GenBank.The animal regression test displayed that the isolate had very strong pathogenicity to tongue sole.The LD_(50) was 3.1 × 10~4 CFU/mL,and it showed pathogenicity to mammals.The antimicrobial susceptibility test showed the isolate was highly sensitive to nrofloxacin,Norfloxacin,Ciprofloxacin,Mequindox;moderately sensitive to Cefradine,Doxycycline;and insensitive to Gentamicin,Ceftriaxone,Tilmicosin,etc.. | Yang Nan Zhang Zhiqiang Wu Tonglei Zhu Jianxin Fu Yanfang Han Hongsheng Wang Hongbin Shi Qiumei Gao Guisheng | 2018 | Animal Husbandry and Feed Science2018，10，2： | 2 |
| 11 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 12 | An improved ant colony al- gorithm for fuzzy clustering in image segmentation 显示文摘 | Han Yanfang Shi Pengfei | 2007 | Neuroeomputing2007，70，46： | 1 |
| 13 | Dynamic resource allocation for device-to-device communication underlaying cellular networks显示文摘 | Xu Yanfang Yin Rui Han Tao | 2014 | International Journal of Communication Systems2014，27，10： | 1 |
| 14 | An Improved Ant Colony Algorithm for Fuzzy Clustering in Image Segmentation显示文摘 | Han Yanfang Shi Pengfei | 2007 | Neurocomputing Archive2007，70，46： | 1 |
| 15 | Optimizing the Mass Ratio of Two Organic Active Fractions in Modified Humic Acid(MHA) Binders tot Iron Ore Pelletizing显示文摘 | Gtdhong HAN Yanfang H/dANG Guanghui LI | 2012 | ISIJ International2012，52，3： | 1 |
| 16 | Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors显示文摘 | Sai Li Yanfang Zhao Kewen Wang Yali Gao Jianming Han Bingbing Cui Ping Gong | 2013 | Bioorganic & Medicinal Chemistry2013，，11： | 1 |
| 17 | Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species显示文摘 | Feng Chen Scott Barman Yanfang Yu Steven Haigh Yusi Wang Huijuan Dou Zsolt Bagi Weihong Han Yunchao Su David J.R. Fulton | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 18 | An improved ant colony algorithm for fuzzy clustering in image segmentation显示文摘 | Han Yanfang Shi Pengfei | 2007 | Neurocomputing2007，70，： | 1 |
| 19 | Simuhaneous extrac- tion and determination of sulfadiazine and sulfamethoxazole in water samples and aquaculture products using BF4/ ( NH4 ) 3 C6 H5 O7 aqueous two-phase system coupled with HPLC 显示文摘 | Li Yanfang Han Juan Yan Yongsheng | 2010 | Journal of the Iranian Chemical Society2010，96，： | 1 |
| 20 | Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2显示文摘哺乳动物的职业人员蛋白质 convertase 皮毛在被发现了在多样的生理、病理学的事件起一个重要作用,例如病毒的 glycoproteins 和细菌的外毒素的激活。小、无毒、高度活跃,在禁止者的皮毛被认为是病毒和细菌引起的疾病的吸引人的药候选人。在这研究,一系列肽禁止者基于 C 终端碎片被设计并且综合嘘一 H1.2,它在皮毛上有禁止的效果在里面。用皮毛的一致底层识别顺序代替禁止者的反应地点在被发现了极大地增加禁止的活动。大多数有势力禁止者,我有 14 氨基酸残余的 4, 有 K 为皮毛的 17 nM 的 i 价值在里面。尽管大多数综合的肽是暂时的禁止者,禁止者我有九氨基酸的 5, ,保留了它的完整的力量,甚至在有皮毛在的 3 h 潜伏期以后在 37 ° C。这些禁止者可以潜在地导致发展抗病毒并且抗菌剂药混合物。 | Suming Wang Jinbo Han Yanfang Wan Wuyuan Lu Chengwu Chi | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 1 |
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