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| 1 | 煤矸石自然风化过程中微量重金属元素的地球化学行为显示文摘通过对不同风化程度的煤矸石样品进行地球化学相的研究,发现对煤矸石来讲,其自然风化过程实际上是一个微量重金属元素的富集过程。在此过程中,重金属的释放受残余相的控制,它们在环境中的迁移和地球化学行为则受铁-锰相和有机相的控制。就煤矸石的环境地球化学效应而言,微量重金属的污染范围是有限的,主要局限在煤矸石堆周围。 | 党志 M. Fowler S. Watts M. Haigh 马英军 肖保华 黄荣贵 邹申清 | 1998 | 自然科学进展(国家重点实验室通讯)1998，8，3： | 28 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | Does Complete Resection of Melanoma Metastatic to Solid Intra-Abdominal Organs Improve Survival?显示文摘 | Thomas F. Wood MD L. Andrew DiFronzo MD D. Michael Rose MD Philip I. Haigh MD FRCSC Stacey L. Stern MS Leslie Wanek DrPH Richard Essner MD FACS Donald L. Morton MD FACS | 2001 | Annals of Surgical Oncology2001，，8： | 2 |
| 4 | 香根草对洪都拉斯玉米产量的影响显示文摘 | Hellin J Haigh M.J | 2002 | 中国水土保持2002，，7： | 2 |
| 5 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 6 | Volume regulation is defective in renal proximal tubule cells isolated from KCNE1 knockout mice 显示文摘 | MILLAR I D HARTLEY J A HAIGH C | 2004 | Exp Physiol2004，89，2： | 1 |
| 7 | The response of tropospheric circulation to perturbations in lower-stratospheric temperature显示文摘 | HAIGH J D BLACKBURN M DAY R | 2005 | J Clim2005，18，17： | 1 |
| 8 | Drug development in anaesthesia:the remifentanil显示文摘 | Haigh CG | 2000 | Minerva Anestesiol2000，66，5： | 1 |
| 9 | Nuclear location of an endogenously expressed antigen, EBNAI, restricts access to macroautophagy and the range of CD4 epitope display显示文摘 | Leung CS Haigh TA Mackay LK | 2010 | Proc Natl Acad Sci USA2010，107，5： | 1 |
| 10 | Changes in germinability, dormancy and viability of Amaranthus retroflexus as affected by depth and duration of burial显示文摘 | Omami Haigh Medd Nicol | 2002 | Weed Research2002，，5： | 1 |
| 11 | Simulated Reflectance Technique for ATM Image Enhancement 显示文摘 | Moore J M Haigh J D | 1997 | International Journal of Remote Sensing1997，18，： | 1 |
| 12 | Ring opening metathesis polymerisations of norbornene and norbornadiene derivatives containing oxygen: a study on the regeneration of Grubbs catalyst显示文摘 | Haigh D M Kenwright A M Khosravi E | 2004 | Tetrahedron2004，60，34： | 1 |
| 13 | pachydermoperiostosis in childhood 显示文摘 | Sinha GP Curtis P Haigh D | 1997 | Br J Rheumatol1997，36，11： | 1 |
| 14 | Sentinel lymph node dissection for thyroid malignancy显示文摘 | Haigh PI Giuliano AE | | 0，，： | 1 |
| 15 | Activated Fps/Fes partially rescues the in vivo developmental potential of Flkl-deficient vascular progenitor cells显示文摘 | Haigh JJ Ema M migh K | 2004 | Blood2004，103，3： | 1 |
| 16 | Factors delaying hospital admission after stroke in Leicestershire显示文摘 | Harper GD Haigh RA Potter JF | 1992 | Stroke1992，23，6： | 1 |
| 17 | No quick switch to low-carbon energy 显示文摘 | Gert Jan Kramer Martin Haigh | 2009 | Nature2009，，462： | 1 |
| 18 | Dual stimulation of Epstein-Barr Virus (EBV)-specific CD4+- and CD8+-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma显示文摘 | Haigh TA Gudgeon NH | 2004 | J Virol2004，78，2： | 1 |
| 19 | Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival显示文摘 | Haigh J J Ema M | 2006 | J Neurosci2006，26，25： | 1 |
| 20 | Assessment of topical corticosteroid preparations:the human skin blanching assay显示文摘 | Kaufer I | 1984 | Int J Pharm1984，19，： | 1 |
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