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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system显示文摘睾丸激素缺乏是普通的在里面有心血管的疾病( CVD )的人,和使随机化的控制安慰剂的试用( RCT )在长期的稳定的咽峡炎在导致锻练的心脏的局部缺血上报导了睾丸激素治疗的有益的效果,功能的锻练能力,最大的氧消费在锻练期间(在长期的心失败( CHF )的 VO 2max)和肌肉力量,一些心血管的风险因素的 Q-T 间隔,和改进弄短。睾丸激素缺乏与不利 CV 风险侧面和死亡被联系。临床、科学的研究提供了机械学的证据支持并且解释 RCT 的调查结果。睾丸激素包括肺的 vasculature 是在冠的发行量和另外的脉管的床以内的快速发作的动脉的血管扩张药并且能减少全面外部全身的脉管的抵抗。证据证明了那睾丸激素调停通过钙隧道封锁(L 钙隧道) 的脉管的反应上的这效果并且刺激钾隧道由直接 nongenomic 机制开。睾丸激素也由刺激超速的钾刺激心脏的 myocytes 的极化操作隧道的电流。睾丸激素改进心脏的输出,功能的锻练能力, VO 2max 和 vagally 调停的动脉的 baroreceptor 在 CHF 的心脏的反射敏感,和另外的机制。独立于心脏的功能上的睾丸激素的利益,睾丸激素替换可以也增加骨胳的肌肉葡萄糖新陈代谢并且提高肌肉发达的力量,能在能力可以包括的功能的锻练贡献改进的两个因素改进了葡萄糖新陈代谢和肌肉力量。睾丸激素由在关键新陈代谢的小径的规章的酶上由 genomic 的联合和葡萄糖举起和胰岛素受体,葡萄糖 transporters,和表示的利用表示的 nongenomic 行动改进葡萄糖利用和类脂化合物新陈代谢包括身体作文,胰岛素电阻,和血胆脂醇过多改进新陈代谢的 CV 风险因素。高密度的脂蛋白胆固醇(高级数据链路控制) 上的效果在研究之间不同因为掉落,升起,或没有在层次的变化被发现了。睾丸激素代替能压制传播支持 inflammatory cytokines 的层次并且刺激有的 interleukin-10 (IL-10 ) 的生产反煽动性并且在有 CVD 的人的 anti-atherogenic 行动。C 反应的蛋白质上的效果都没被检测。clotting 因素上的不利效果都没被检测。RCT 清楚地没表明那睾丸激素在颈动脉 intima 厚度或冠的钙免职改进或不利地影响象减小那样的动脉粥样硬化的代理人标记的任何重要证据。动脉粥样硬化的预防或改善上的睾丸激素的任何效果是可能的在在在睾丸激素 RCT 使用了的 statin 治疗审判和并非月出现的年发生。从长期的流行病学的研究的证据的重量支持在与睾丸激素缺乏对待人的研究在主要不利 CV 事件(权标) 和死亡由减小证实了的保护的效果。睾丸激素被代替了到正常健康范围的 RCT 都没报导向上的一个重要好处或不利效果也没有任何最近的元分析。 | T Hugh Jones Daniel M Kelly | 2018 | Asian Journal of Andrology2018，20，2： | 6 |
| 5 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 6 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 7 | Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associteed with reduced B ceils and serum cytotoxicity on mouse cell line expressing AehR显示文摘 | Poussin M A Goluszko E Hughes T K | 2000 | J Neuroimmunol2000，111，： | 2 |
| 8 | 责任制医疗照护机构——美国的经验与教训显示文摘Hugh Alderwick与同事强调:英国国家健康体系(NHS)的政策制定者应实事求是地看待新型医疗保健模式带来的潜在收益。英格兰国家健康体系(NHS)决策圈都在谈论源自美国的一个新概念——责任制医疗照护机构(ACOs)。英格兰NHS和卫生部长认为ACO(s以及相关的责任制医疗体系)是改进NHS服务的重要途径。 | Hugh Alderwick Stephen M Shortell Adam D M Briggs Elliott S Fisher 周红霞(译) 肖月(校) | 2019 | 中国医院院长2019，0，12： | 2 |
| 9 | 胸腹主动脉瘤:杂交修复术结果显示文摘目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经验。方法:从2005年3月—2012年6月间58名患者在单中心接受解剖外内脏血管去分支化及随后的动脉瘤腔内隔绝术。内脏旁路的中位数为4支,最初的33例采用同期手术方式,而最近的25例采用分期手术。结果:患者中位年龄为69.0岁,50%为女性,所有患者存在严重合并症而不适合传统开放修复术。平均主动脉直径(6.7±1.2)cm,30 d/住院病死率、脑卒中率、永久性轻瘫/截瘫率分别为9%、0%以及4%。最近25例分期手术患者的这三种并发症率分别为4%、0%以及0%。平均随访时间(26±21)个月,内脏人工血管通畅率95.3%,所有闭塞的内脏人工血管均为肾动脉,无1例引起永久性截瘫,2例患者需再干预,1例出现Ib型内漏,1例出现III型内漏,5年免于再干预率为94%,Kaplan-Meier总体生存率为1年78%、5年62%,5年主动脉相关生存率为87%。结论:这些更新后的结果 ,继续支撑着这一观点:运用完全内脏动脉去分支联合动脉瘤腔内隔绝的杂交技术治疗高龄且不适合传统开放手术的高危TAAA患者是一种理想的选择,而采取分期手术的方式能取得更佳的结果。 | Gchad Hughes Nicholas D Andersen Jennifer M Hanna Richard L McCann 老启芳 | 2015 | 中国普通外科杂志2015，24，6： | 2 |
| 10 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 11 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 12 | Incisional hernia: a 10 year prospective study of incidence and attitudes显示文摘 | Mudge M Hughes LE | 1985 | Br J Surg1985，72，1： | 1 |
| 13 | Kinetic Study of the Reaction Between Nitrous Acid and Sulphamic Acid显示文摘 | Hughes M N | 1956 | J Chem Soci (Resumed)1956，，： | 1 |
| 14 | TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation显示文摘 | Hughes P Mason-parker SE | 1997 | Mol Brain Res1997，46，12： | 1 |
| 15 | Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous syeterm 显示文摘 | Dragunow M | 1995 | Pharmacol Rev1995，47，1： | 1 |
| 16 | C/EBPα and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells显示文摘 | HUGHES D E RAUSA F M | 2006 | Hepatology2006，43，2： | 1 |
| 17 | Elastic tripping analysis of asymmetrical stiffeners 显示文摘 | Ma M | 1996 | Computers & Structures1996，60，3： | 1 |
| 18 | A new finite element formulation for computational fluid dynamics: Ⅷ: the Galerkin least squares method for advective diffusive equations显示文摘 | HUGHES T J R FRANCA L P HULBERT G M | 1989 | Computer Methods in Applied Mechanics and Engineering1989，73，2： | 1 |
| 19 | Analysis of passing sequences, shots and goals in soccer显示文摘 | Hughes M Franks I | 2005 | J Sports Sci2005，23，5： | 1 |
| 20 | Occupational exp- osure to pesticides and risk of non-hodgkln' s lymphoma显示文摘 | FRITSCHI L BENKE G HUGHES A M | 2005 | Am J Epidemiol2005，162，9： | 1 |
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