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| 1 | Novel insight into mechanisms of cholestatic liver injury显示文摘Cholestasis results in a buildup of bile acids in serum and in hepatocytes.Early studies into the mechanisms of cholestatic liver injury strongly implicated bile acidinduced apoptosis as the major cause of hepatocellular injury.Recent work has focused both on the role of bile acids in cell signaling as well as the role of sterile inflammation in the pathophysiology.Advances in modern analytical methodology have allowed for more accurate measuring of bile acid concentrations in serum,liver,and bile to very low levels of detection.Interestingly,toxic bile acid levels are seemingly far lower than previously hypothesized.The initial hypothesis has been based largely upon the exposure of μmol/L concentrations of toxic bile acids and bile salts to primary hepatocytes in cell culture,the possibility that in vivo bile acid concentrations may be far lower than the observed in vitro toxicity has far reaching implications in the mechanism of injury.This review will focus on both how different bile acids and different bile acid concentrations can affect hepatocytes during cholestasis,and additionally provide insight into how these data support recent hypotheses that cholestatic liver injury may not occur through direct bile acid-induced apoptosis,but may involve largely inflammatory cell-mediated liver cell necrosis. | Benjamin L Woolbright Hartmut Jaeschke | 2012 | World Journal of Gastroenterology2012，18，36： | 21 |
| 2 | New Butenolides from Two Marine Streptomycetes显示文摘 | Venugopal JR Michael S Hartmut L | 2000 | J Nat Prod2000，63，： | 1 |
| 3 | Triterpenoids,Essential oil and photooxidative 2,13-lactonization of oleanolic acid from Lantana Camara显示文摘 | Hartmut L | 2000 | Phytochemistry2000，54，： | 1 |
| 4 | Determination of total aryte- noids and chlorophylls a and b of leaf extracts in differ- ent solvents显示文摘 | Hartmut K L Alan R W | 1983 | Bioche Soc Trans1983，11，： | 1 |
| 5 | Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence,regulation and fuctional complementation显示文摘 | | 1999 | Biochimica et Biophysica Acta1999，1446，： | 1 |
| 6 | Very High-Frequency Radar Mapping of Surface Currents显示文摘 | SHAY L K COOK T M HARTMUT P | 2002 | IEEE Journal of Oceanic Engineering2002，27，2： | 1 |
| 7 | Simultaneous HPLC analysis of triameinolone acetonide and budesonide in microdialysate and rat plasma: Application to a pharmacokinetic study 显示文摘 | Manuela de L T Vieira Rajandra P Singh Hartmut Derendorf | 2010 | J Chromatography B2010，878，29： | 1 |
| 8 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 9 | Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia 显示文摘 | Michael S Hartmut L Thomas W | 1998 | J Am Coll Cardiol1998，32，： | 1 |
| 10 | Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor显示文摘 | Matthias L?hn Oliver Plettenburg Yuri Ivashchenko Aimo Kannt Armin Hofmeister Dieter Kadereit Matthias Schaefer Wolfgang Linz Markus Kohlmann Jean-Marc Herbert Philip Janiak Stephen E. O’Connor Hartmut Ruetten | 2009 | Hypertension2009，，3： | 1 |
| 11 | Heparin-induced release of protein-bound solutions during hemodiatysis is an in vitro artifact显示文摘 | Riga De S Jacqueline V Hartmut L | 2001 | Clinical Chemistry2001，47，： | 1 |
| 12 | Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury显示文摘 | HARTMUT J JOHN J L | 2003 | Gastroenterology2003，125，4： | 1 |
| 13 | A European care bundle for prevention of ventilator - associated pneumonia显示文摘 | Jordi R Hartmut L Giuseppe C | 2010 | Intensive Care Med2010，36，： | 1 |
| 14 | European care bundle for prevention of ventilatorassociated pneumonia显示文摘 | Jordi R Hartmut L | 2010 | Intensive Care Med2010，36，5： | 1 |
| 15 | Bacteriorhodopsin显示文摘 | JANOS K LANYI HARTMUT L | 2001 | Current Opinion in Structural Biology2001，11，4： | 1 |
| 16 | A note on stability and stabilizability of neutral systems显示文摘 | HARTMUT L LUCIANO P | 1994 | IEEE Trans Automat Contr1994，39，1： | 1 |
| 17 | Struc- tures and absolute configuration of three tx-pyrones from an endo- phytic fungus Aspergillus niger 显示文摘 | FERDINAND MT MICHEL KT HARTMUT L | 2013 | Tetrahedron2013，69，34： | 1 |
| 18 | A survey o{ video encryption algorithm显示文摘 | Fuwen L Hartmut K | 2010 | Computers and Security2010，29，1： | 1 |
| 19 | Increased Ornithine-Derived Polyamines Cause Airway Hyperresponsiveness in a Mouse Model of Asthma显示文摘 | North Michelle L Grasemann Hartmut Khanna Nivedita Inman Mark D Gauvreau Gail M Scott Jeremy A | 2013 | American Journal of Respiratory Cell and Molecular Biology2013，，6： | 1 |
| 20 | Greenhouse effect of NOX显示文摘 | Gerhard Lammel Hartmut Gra?l | 1995 | Environmental Science and Pollution Research1995，，1： | 1 |
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