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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach显示文摘 | Karsten Sch?ller Maike Massmann Gertraud Markl Mathias Kunz Gunther Fesl Hartmut Brückmann Thomas Pfefferkorn J?rg-Christian Tonn Christian Schichor | 2013 | Journal of Neurology2013，，4： | 1 |
| 3 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 4 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 5 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 6 | Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury显示文摘 | HARTMUT J JOHN J L | 2003 | Gastroenterology2003，125，4： | 1 |
| 7 | Efficient implementation of an active set algorithm for large-scale portfolio selection显示文摘 | Michael Stein Jürgen Branke Hartmut Schmeck | 2007 | Computers and Operations Research2007，，： | 1 |
| 8 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee显示文摘 | David W Dempster Juliet E Compston Marc K Drezner Francis H Glorieux John A Kanis Hartmut Malluche Pierre J Meunier Susan M Ott Robert R Recker A Michael Parfitt | 2012 | J Bone Miner Res2012，，1： | 1 |
| 9 | Design rules for MR fluid actuators in different working modes 显示文摘 | Rail B Hartmut J | 1998 | SPIE1998，3045，： | 1 |
| 10 | Mechanisms of hepatotoxicity 显示文摘 | Hartmut J Gregory J G Arthur I C | 2002 | Toxicological Sciences2002，65，： | 1 |
| 11 | The all-diode-pumped laser system POLARIS——an experimentalist's tool generating ultra-high contrast pulses with high energy显示文摘The development,the underlying technology and the current status of the fully diode-pumped solid-state laser system POLARIS is reviewed.Currently,the POLARIS system delivers 4 J energy,144 fs long laser pulses with an ultra-high temporal contrast of 5 × 1012 for the ASE,which is achieved using a so-called double chirped-pulse amplification scheme and cross-polarized wave generation pulse cleaning.By tightly focusing,the peak intensity exceeds 3.5 × 1020 W cm-2.These parameters predestine POLARIS as a scientific tool well suited for sophisticated experiments,as exemplified by presenting measurements of accelerated proton energies.Recently,an additional amplifier has been added to the laser chain.In the ramp-up phase,pulses from this amplifier are not yet compressed and have not yet reached the anticipated energy.Nevertheless,an output energy of 16.6 J has been achieved so far. | Marco Hornung Hartmut Liebetrau Andreas Seidel Sebastian Keppler Alexander Kessler Jrg Krner Marco Hellwing Frank Schorcht Diethard Klpfel Ajay K.Arunachalam Georg A.Becker Alexander Svert Jens Polz Joachim Hein Malte C.Kaluza | 2014 | High Power Laser Science and Engineering2014，2，3： | 1 |
| 12 | A clinical trial of a whole-virus H5NI vaccine derived from cell culture显示文摘 | Hartmut J Ehrlich MD Markus Muller MD | 2008 | N Eng J Med2008，358，24： | 1 |
| 13 | Compensation of hysteresis in solid-state actuators 显示文摘 | JURGEN S HARTMUT J | 1995 | Sensors and Actuators A1995，49，： | 1 |
| 14 | Multi-objective particle swarm optimization on computer grids显示文摘 | Mostaghim S Branke J Hartmut S | 2007 | Joumal of Artificial Evolution and Application2007，，4： | 1 |
| 15 | Role of neutrophils in acute inflammatory liver injury显示文摘 | TADASHI H | 2006 | Liver International2006，26，8： | 1 |
| 16 | High-level DNA amplifications are common genetic aberrations in B cell neoplasms 显示文摘 | Werner C A Hartmut D Stefan J | 1997 | Am J Pathol1997，151，2： | 1 |
| 17 | Ischemia-reperfusion injury and preconditioning显示文摘 | Hartmut J | 2003 | Am J Physiol Gastrointest Liver Physiol2003，284，1： | 1 |
| 18 | 查看详情显示文摘 | J udit C Hartmut F Gijsbertus D W | | 0，，： | 1 |
| 19 | Dynamics of Notch expression during murine prostate development and tumorigenesis显示文摘 | J ianyong S Sarajane R Hartmut K | 2001 | Cancer Research2001，61，： | 1 |
| 20 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
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