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| 1 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 2 | The treatment of complex female urethral pathology显示文摘Lower urinary tract symptoms(LUTS)in women produce significant bother.Common conditions causing LUTS in women include urinary tract infections,overactive bladder,and stress incontinence.Urethral diverticulae and female urethral strictures are rare pathologies.They can cause symptoms,which can mimic commoner conditions,leading to delay in diagnosis and unnecessary delay in treatment.In this article,we discuss in detail the definition,symptoms,epidemiology,pathogenesis,diagnosis,and treatment option for these two conditions.Further understanding of these conditions will aid in the proper diagnosis and prevent delay in management. | Reem Aldamanhori Richard Inman | 2018 | Asian Journal of Urology2018，5，3： | 4 |
| 3 | Paving the Way to Open Data显示文摘It is easy to argue that open data are critical to enabling faster and more effective research discovery.In this article,we describe the approach we have taken at Wiley to support open data and to start enabling more data to be FAIR data(Findable,Accessible,Interoperable and Reusable)with the implementation of four data policies:“Encourages”,“Expects”,“Mandates”and“Mandates and Peer Reviews Data”.We describe the rationale for these policies and levels of adoption so far.In the coming months we plan to measure and monitor the implementation of these policies via the publication of data availability statements and data citations.With this information,we’ll be able to celebrate adoption of data-sharing practices by the research communities we work with and serve,and we hope to showcase researchers from those communities leading in open research. | Yan Wu Elizabeth Moylan Hope Inman Chris Graf | 2019 | Data Intelligence2019，1，4： | 3 |
| 4 | A randomized trial comparing the Tennant Biomodulator to transcutaneous electrical nerve stimulation and traditional Chinese acupuncture for the treatment of chronic pain in military service members显示文摘Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012. | Kimberly S.Peacock Erika Stoerkel Salvatore Libretto Weimin Zhang Alice Inman Michael Schlicher John D.Cowsar Jr David Eddie Joan Walter | 2020 | Military Medical Research2020，7，2： | 3 |
| 5 | Lamb波结构损伤检测温度补偿方法仿真与实验研究显示文摘基于压电激励Lamb波传播过程分析研究了信号扩展时域温度补偿方法,分别进行了不同温度下Lamb波传播与损伤检测的有限元数值仿真和实验,利用基准信号选择和基准信号扩展的温度补偿方法处理波动响应信号。仿真和实验结果表明了温度补偿方法的有效性,得到了基准信号集中最大温度间隔要求,能够有效识别环境温度变化下的结构损伤。 | 屈文忠 D J Inman | 2013 | 振动工程学报2013，26，3： | 3 |
| 6 | Broadband piezoelectric power generation on high-energy orbits of the bistable Duffing oscillator with electromechanical coupling显示文摘 | A. Erturk D.J. Inman | 2010 | Journal of Sound and Vibration2010，，10： | 2 |
| 7 | Costimulation,coinhibition and cancer显示文摘 | Inman B A Frigola X Dong H | 2007 | Curr Cancer Drug Targets2007，7，1： | 1 |
| 8 | Eigenstructure Assignment and Controller Optimization for Mechanical Systems显示文摘 | Inman D J | 1994 | IEEE Transactions on Control Systems and Technology1994，2，2： | 1 |
| 9 | Along-termst study of the inflammayoey effeCt of low-dose budesde plus formoterol versus high-dose budesonide in asthma显示文摘 | KIPS J C O CONNOR B J INMAN M D | 2000 | Am J Respir Crit Care Med2000，161，： | 1 |
| 10 | Direct updating of damping and stiffness matrices显示文摘 | Friswell M I Inman D J Pilkey D F | 1998 | AIAA Journal1998，36，3： | 1 |
| 11 | Effects of all-trans-retinoic acid on melanocyte adhesion and motility 显示文摘 | Situ R Inman DR Fligiel SEG | 1993 | Dermatology1993，186，： | 1 |
| 12 | Problem-based learning and the medical school:another case of the emperor's new clothes?显示文摘 | BUTLER R INMAN D LOBB D | 2005 | Adv Physiol Educ2005，29，4： | 1 |
| 13 | Golimumab administered subcutaneously every 4 weeks in ankylosing spondy- litis: 104-week results of the GO-RAISE study显示文摘 | Jurgen Braun Atul Deodhar Robert D Inman | 2012 | Ann Rheum Dis2012，71，5： | 1 |
| 14 | Asian American families' collectivistic coping strategies in response to 9/11 显示文摘 | Yeh Inman Kim Okubo | 2006 | Cultural Diversity and Ethnic Minority Psychology2006，12，： | 1 |
| 15 | The challenge of early diagnosis in ankylosing spondylitis显示文摘 | O'Shea F Salonen D Inman R | 2007 | Journal of Rheumatology2007，34，1： | 1 |
| 16 | Lipophilic stinging nettle extracts possess potent anti-inflammatory activity,are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders显示文摘 | Johnson T A Sohn J Inman W D | 2013 | Phytomedicine2013，20，2： | 1 |
| 17 | ELECTROWINNING ZINC FROM CHLORIDE MELTS IN BIPOLAR CELL显示文摘ELECTROWINNINGZINCFROMCHLORIDEMELTSINBIPOLARCELLZhao;Guangwen(DepartmentofPhysicalChemistry,UniversityofScienceandTechnoloygB... | Zhao Guangwen(Department of Physical Chemistry ,University of Science and Technoloyg Beijing , Beijing 100083) Inman D(Imperial College, London SW 7 2BP) | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 1 |
| 18 | Chained cross-training of assembly line workers显示文摘 | Inman R R Jordan W C Blumenfeld D E | 2004 | International Journal of Production Research2004，42，10： | 1 |
| 19 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 20 | Endothelin-receptor blockade mitigates the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats 显示文摘 | INMAN S R PLOTT W K POMILEE R A | 2003 | Transplantation2003，75，10： | 1 |
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