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| 1 | Osteoporosis:A Silent Disease with Complex Genetic Contribution显示文摘Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a strong genetic component. In this review, the evidence for a genetic contribution to osteoporosis and related phenotypes is summarized alongside with methods used to identify osteoporosis susceptibility genes. The key biological pathways involved in the skeleton and bone development are discussed with a particular focus on master genes clustered in these pathways and their mode of action. Furthermore, the most studied single nucleotide polymorphisms(SNPs) analyzed for their importance as genetic markers of the disease are presented. New data generated by nextgeneration sequencing in conjunction with extensive meta-analyses should contribute to a better understanding of the genetic basis of osteoporosis and related phenotype variability. These data could be ultimately used for identifying at-risk patients for disease prevention by both controlling environmental factors and providing possible therapeutic targets. | Maryam Marl Golchin Laleh Heidari Seyyed Mohammad Hossein Ghaderian Haleh Akhavan-Niaki | 2016 | Journal of Genetics and Genomics2016，43，2： | 15 |
| 2 | Forecasting the number of zoonotic cutaneous leishmaniasis cases in south of Fars province, Iran using seasonal ARIMA time series method显示文摘Objective: To predict the trend of cutaneous leishmaniasis and assess the relationship between the disease trend and weather variables in south of Fars province using Seasonal Autoregressive Integrated Moving Average(SARIMA) model,Methods: The trend of cutaneous leishmaniasis was predicted using Mini tab software and SARIMA model,Besides,information about the disease and weather conditions was collected monthly based on time series design during January 2010 to March 2016,Moreover,various SARIMA models were assessed and the best one was selected,Then,the model's fitness was evaluated based on normality of the residuals' distribution,correspondence between the fitted and real amounts,and calculation of Akaike Information Criteria(AIC) and Bayesian Information Criteria(BIC),Results: The study results indicated that SARIMA model(4,1,4)(0,1,0)(12) in general and SARIMA model(4,1,4)(0,1,1)(12) in below and above 15 years age groups could appropriately predict the disease trend in the study area,Moreover,temperature with a three-month delay(lag3) increased the disease trend,rainfall with a four-month delay(lag4) decreased the disease trend,and rainfall with a nine-month delay(lag9) increased the disease trend,Conclusions: Based on the results,leishmaniasis follows a descending trend in the study area in case drought condition continues,SARIMA models can suitably measure the disease trend,and the disease follows a seasonal trend. | Mehdi Sharafi Haleh Ghaem Hamid Reza Tabatabaee Hossein Faramarzi | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 9 |
| 3 | Fuzzy expert system for diagnosing diabetic neuropathy显示文摘AIM To design a fuzzy expert system to help detect and diagnose the severity of diabetic neuropathy. METHODS The research was completed in 2014 and consisted of two main phases. In the first phase, the diagnostic parameters were determined based on the literature review and by investigating specialists' perspectives(n= 8). In the second phase, 244 medical records related to the patients who were visited in an endocrinology and metabolism research centre during the first six months of 2014 and were primarily diagnosed with diabetic neuropathy, were used to test the sensitivity, specificity, and accuracy of the fuzzy expert system.RESULTS The final diagnostic parameters included the duration of diabetes, the score of a symptom examination based on the Michigan questionnaire, the score of a sign examination based on the Michigan questionnaire, the glycolysis haemoglobin level, fasting blood sugar, blood creatinine, and albuminuria. The output variable was the severity of diabetic neuropathy which was shown as a number between zero and 10, had been divided into four categories: absence of the disease,(the degree of severity) mild, moderate, and severe. The interface of the system was designed by ASP.Net(Active Server Pages Network Enabled Technology) and the system function was tested in terms of sensitivity(true positive rate)(89%), specificity(true negative rate)(98%), and accuracy(a proportion of true results, both positive and negative)(93%).CONCLUSION The system designed in this study can help specialistsand general practitioners to diagnose the disease more quickly to improve the quality of care for patients. | Meysam Rahmani Katigari Haleh Ayatollahi Mojtaba Malek Mehran Kamkar Haghighi | 2017 | World Journal of Diabetes2017，8，2： | 5 |
| 4 | Synthesis,Contact Printing,and Device Characterization of Ni-Catalyzed,Crystalline InAs Nanowires显示文摘InAs nanowires have been actively explored as the channel material for high performance transistors owing to their high electron mobility and ease of ohmic metal contact formation.The catalytic growth of nonepitaxial InAs nanowires,however,has often relied on the use of Au colloids which is non-CMOS compatible.Here,we demonstrate the successful synthesis of crystalline InAs nanowires with high yield and tunable diameters by using Ni nanoparticles as the catalyst material on amorphous SiO_(2) substrates.The nanowires show superb electrical properties with field-effect electron mobility~2700 cm^(2)/Vs and ION/IOFF>10^(3).The uniformity and purity of the grown InAs nanowires are further demonstrated by large-scale assembly of parallel arrays of nanowires on substrates via the contact printing process that enables high performance,“printable”transistors,capable of delivering 510 mA ON currents(~400 nanowires). | Alexandra C.Ford Johnny C.Ho Zhiyong Fan Onur Ergen Virginia Altoe Shaul Aloni Haleh Razavi Ali Javey | 2008 | Nano Research2008，1，1： | 3 |
| 5 | Immunotherapy-induced Hepatotoxicity:A Review显示文摘Immune checkpoint inhibitors(ICIs)suppress the func-tion of immune checkpoints,which are involved in down-regulating immune responses.These lead to an increased activation of the function of T cells,increased release of cytokines,and decreased activity of regulatory T cells.This allows for a more significant and less regulated im-mune response and subsequent enhanced cytotoxic activity against cancer cells.A number of cancers are now being treated with these agents and this increased use has re-sulted in more reports of toxicity.While almost every organ can be affected,the skin,gastrointestinal tract,liver,and endocrine glands are most commonly involved.It is neces-sary that gastroenterologists and hepatologists familiarize themselves with diagnostic steps and management plan in patients with these undesirable outcomes.When assessing for possible ICIs induced hepatotoxicity,it is of utmost im-portance to use a formal scoring system such as the Rous-sel Uclaf causality assessment method(RUCAM)to assess for risk factors,alternative causes,and response to cessa-tion and re-exposure of a given drug.While this review is based on studies with and without RUCAM,the conclusions were carefully established mainly from studies that used RUCAM.The aim of this review is to provide information on the epidemiology,risk factors,clinical presentation,di-agnostic tools,and management plan based on the most recent studies of immunotherapy-induced hepatotoxicity. | Teresa Da Cunha George Y.Wu Haleh Vaziri | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 2 |
| 6 | Hemoglobin A1C in non-diabetic patients: An independent predictor of coronary artery disease and its severity显示文摘 | Haleh Ashraf Mohammad Ali Boroumand Alireza Amirzadegan Shaghayegh Ashraf Talesh Gholamreza Davoodi | 2013 | Diabetes Research and Clinical Practice2013，，3： | 2 |
| 7 | Molecular Insight in Gastric Cancer Induction: An Overview of Cancer Stemness Genes显示文摘 | Haleh Akhavan-Niaki Ali Akbar Samadani | 2014 | Cell Biochemistry and Biophysics2014，，3： | 2 |
| 8 | Assessment of Asphalt Specimen Homogeneity显示文摘 | Richard H. McCuen Haleh Azari | 2001 | Journal of Transportation Engineering2001，，5： | 2 |
| 9 | Stuart, Optimum compaction temperature for modified binders显示文摘 | Haleh Azaril Richard H Me Cuen | 2003 | Journal of Transportation Engineering ASCE2003，129，： | 1 |
| 10 | Effect of leachate recirculation on mesophilic anaerobic digestion of food waste 显示文摘 | Haleh Shahriari Mostafa Warith Mohamed Hamoda | 2012 | Waste Management2012，32，3： | 1 |
| 11 | A comparison of the theory of moisture diffusion in plastic encapsulated mieroelectronics with moisture sensor chip and weight gain measurements 显示文摘 | HALEH A CRAIG H MICHAEL G P | 2002 | IEEE Trans on Components and Packaging Teeh2002，25，1： | 1 |
| 12 | Effects of depression and anxiety symptoms on cardiac mortality following myocardial infarction: A 2-year follow-up显示文摘 | Seyed Hamzeh Hosseini Keyvan Yousefnejad Sasan Tabiban Vida Nesarhoseyni Babak Bagheri Asadolah Mohseni Kiasari Ali Ghaemian Seyed Naser Ghadirnejad Hamideh Azimi Lolati Fatemeh Nasiri Amiri Haleh Ashraf Vahid Mokhberi | 2011 | International Journal of Psychiatry in Clinical Practice2011，，2： | 1 |
| 13 | Optimum compaction temperature for modified binders显示文摘 | Haleh Azari | 2003 | J Trans Eng2003，129，5： | 1 |
| 14 | Study on UWB systemsin the presence of narrowband interference显示文摘 | HALEH H ROZEHA A R | 2008 | Proceedings of 2008Student Conference on Researchand Development2008，，： | 1 |
| 15 | A COMPARISON OF CYTOLOGY AND FLUORESCENCE IN SITU HYBRIDIZATION FOR THE DETECTION OF UROTHELIAL CARCINOMA显示文摘 | KEVIN C. HALLING WALTER KING IRINA A. SOKOLOVA REID G. MEYER HALEH M. BURKHARDT AMY C. HALLING JOHN C. CHEVILLE THOMAS J. SEBO SANJAY RAMAKUMAR CHRISTOPHER S. STEWART SHANE PANKRATZ DENNIS J. O’KANE STEVEN A. SEELIG MICHAEL M. LIEBER ROBERT B. JENKINS | 2000 | The Journal of Urology2000，，5： | 1 |
| 16 | Quantum dots:synthesis,bioapplications and toxicity显示文摘 | Alireza V Haleh M Mohammad S | 2012 | Nanosale Res Left2012，7，1： | 1 |
| 17 | Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review显示文摘Primary sclerosing cholangitis is a disease affecting around 0.006–0.016%of the population.Of these,around 75%have concomitant inflammatory bowel disease(IBD)according to the most recent epidemiological studies.Several theories have been proposed regarding the pathogenesis of primary sclerosing cholangitis(PSC).These include changes in the function of cholangiocytes,effects of the gut microbiome,association with specific human leukocyte antigen haplotypes and dysregulation of the immune system.However,these do not explain the observed association with IBD.Moreover,there are considerable differences in the frequency and outcomes between patients with PSC and ulcerative colitis compared with PSC and Crohn’s disease.The aim of this review is to appraise the most recent studies that have contributed to the epidemiology,advances in the pathophysiology,and characterization of important clinical aspects of the association of PSC and IBD. | Teresa Da Cunha Haleh Vaziri George Y.Wu | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 1 |
| 18 | Three dimensional nanopillar array photovoltaics on low cost and flexible substrates 显示文摘 | Fan Zhiyong Razavi Haleh Do Jae-won | 2009 | Nature Materials2009，8，8： | 1 |
| 19 | Influence of film thickness, substrate temperature and nano-structural changes on the optical properties of UHV deposited Ti thin films 显示文摘 | Hadi S Haleh K | 2007 | J Phys D: Appl Phys2007，40，： | 1 |
| 20 | Case report and review of esophageal lichen planus treated with fluticasone显示文摘Lichen planus is a fairly common chronic idiopathic disorder of the skin,nails and mucosal surfaces.Esophageal involvement of this disease on the other hand is rare and only about 50 cases have been reported in literature.Given its rarity,it can be difficult to diagnose and may be easily misdiagnosed as reflux esophagitis.Currently,there are no clear recommendations on the optimal management of this disease and little is known about the best treatment approach.Systemic steroids are usually the first line treatment and offer a favorable response.In this report,we would like to present a novel approach in the management of esophageal lichen planus in a middle-aged woman treated successfully with swallowed fluticasone propionate 220 mcg twice a day for 6 wk,as evidenced by objective clinical findings.Based on our review of related literature and experience in this patient,we feel that a trial of swallowed fluticasone may be a prudent approach in the management of these patients since it has a more favorable side effect profile than systemic treatment. | Marie Lourdes Ynson Faripour Forouhar Haleh Vaziri | 2013 | World Journal of Gastroenterology2013，19，10： | 1 |
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