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| 1 | 暗娼人群STD/AIDS危险行为 认知状况及求医现状分析显示文摘目的 了解影响暗娼性传播疾病 /艾滋病 (STD/AIDS)流行的行为危险因素、认知状况和防治需求 ,为建立可行的预防、治疗和关怀护理模式 ,制定相关政策和资源分配提供依据。方法 采用小组访谈、个人深入访谈以及流行病学问卷等方法 ,对试点省 (四川、云南省 )暗娼人群STD/AIDS相关的行为、认知状况和求医现状进行调查和访问。结果 两试点省暗娼人群对STD/AIDS相关知识认识不全面 ;性交易时预防性病的措施不正确 ,安全套使用率低 ;患性病时常到个体诊所进行不正规治疗。结论 暗娼人群对STD/AIDS高危行为的认识和预防措施有待提高 ,求医方式需加以正确的引导 ,建立相应的社会支持系统是暗娼性健康教育之关键。 | 陈虹 程峰 栾荣生 胡虹 张灵麟 张建新 万绍平 张勇 程何荷 杨志伟 William Stewart 沈洁 | 2003 | 中国艾滋病性病2003，9，6： | 50 |
| 2 | 暗娼安全套使用及其影响因素的研究显示文摘目的 了解四川和云南两省暗娼安全套使用情况及其影响因素。方法 通过社会学小组座谈、个人深入访谈和流行病学横断面问卷调查 ,收集暗娼的社会背景、性病艾滋病知识、性行为特点和安全套使用情况等资料。结果 商业性性行为中大多数暗娼不能坚持每次使用安全套 ;影响安全套使用的因素主要是 :嫖客不愿使用、经济原因和安全套不易获得 ;流行病学调查发现避孕措施也是影响安全套使用的因素 (OR =7 62 3 ,95%CI3 83 2~15 165)。结论 四川和云南两省暗娼安全套使用频率较低 。 | 程峰 陈虹 栾荣生 张灵麟 胡虹 张建新 万绍平 杨志伟 William Stewart 沈洁 | 2004 | 中国公共卫生2004，20，1： | 37 |
| 3 | 城市生态网络功能性连接辨识方法显示文摘城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以新西兰基督城为案例,分别利用景观发展强度指数建立阻力面,新西兰鸡毛松(Dacrycarpus dacrydioides)种子最大传播距离作为连接阈值来模拟、评价网络连接。结果表明:在1200 m距离阈值下,共有408条连接,其重要性分为10类。其中Richmond—Petrie公园,Hansons—Auburn保护地,Centaurus公园—King George保护地是整个生态网络的关键连接;若去除,景观整体连接度将下降31.73%。此外,研究发现连接重要值与两端的源面积之和没有显著相关性,即面积大的源斑块之间的连接不一定对网络构建起关键作用,这一结论还有待进一步证明。针对缺少动物迁移资料的城市环境,改进最小费用模型和网络连接分析的部分参数;可操作性与实用性强,对中国城市区域生态恢复建设、栖息地选择具有借鉴意义。 | 陈春娣 Meurk D. Colin Ignatieva E. Maria Stewart H. Glenn 吴胜军 | 2015 | 生态学报2015，35，19： | 25 |
| 4 | 鼻阻塞症状评估(NOSE)量表中文版的研制显示文摘目的研制鼻阻塞症状评估量表(NOSE)中文版。方法遵照国际规范程序引进量表,经正、逆向翻译,专家小组综合讨论,预试及初步考核满意后,选择鼻中隔偏曲患者223例和健康对照组80名进一步测试性能,接受临床检验,并与英文源量表及其他语言版本量表比较。采用SPSS19.0软件进行数据分析。结果中文版NOSE量表各项性能考核结果均达到或接近检验水准,与英文源量表性能相当。①可行性:试验组和对照组量表的接收率分别为97.6%和94.1%;平均完成时间分别为(1.5±0.5)、(1.0±0.5)min。②信度:克朗巴赫系数d=0.869,重测信度Spearman秩相关系数rs=0.996。③效度:量表得到专家认可;与医学结局研究短表-36(medicaloutcomesstudyshortform-36,SF.36)和视觉模拟量表(visualanaloguescale,VAS)的相关系数分别为-0.837和0.725;量表结构与源量表设计结构吻合。④反应度:术后3个月评分的标准化反应均数与效应量分别为1.34和1.21。⑤灵敏度:Mann—WhitneyU检验显示量表能有效区分试验组(秩均值117.81)和对照组(秩均值43.19)生存质量,差异有统计学意义(P值均〈0.01)。临床检验表明NOSE评分与鼻阻力参数具有相关性。结论中文版NOSE量表考核结果满意,可作为评估鼻阻塞症状的工具。 | 董栋 赵玉林 Michael G. Stewart 孙亮 程慧娟 王静静 李伟亚 | 2014 | 中华耳鼻咽喉头颈外科杂志2014，49，1： | 20 |
| 5 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 6 | Treatment of diabetic retinopathy: Recent advances and unresolved challenges显示文摘Diabetic retinopathy(DR) is the leading cause of blindness in industrialized countries. Remarkable advances in the diagnosis and treatment of DR have been made during the past 30 years, but several important management questions and treatment deficiencies remain unanswered. The global diabetes epidemic threatens to overwhelm resources and increase the incidence of blindness, necessitating the development of innovative programs to diagnose and treat patients. The introduction and rapid adoption of intravitreal pharmacologic agents, particularly drugs that block the actions of vascular endothelial growth factor(VEGF) and corticosteroids, have changed the goal of DR treatment from stabilization of vision to improvement. Anti-VEGF injections improve visual acuity in patients with diabetic macular edema(DME) from 8-12 letters and improvements with corticosteroids are only slightly less. Unfortunately, a third of patients have an incomplete response to anti-VEGF therapy, but the best second-line therapy remains unknown. Current first-line therapy requires monthly visits and injections; longer acting therapies are needed to free up healthcare resources and improve patient compliance. VEGF suppression may be as effective as panretinal photocoagulation(PRP) for proliferative diabetic retinopathy, but more studies are needed before PRP is abandoned. For over 30 years laser was the mainstay for the treatment of DME, but recent studies question its role in the pharmacologic era. Aggressive treatment improves vision in most patients, but many still do not achieve reading and driving vision. New drugs are needed to add to gains achieved with available therapies. | Michael W Stewart | 2016 | World Journal of Diabetes2016，7，16： | 18 |
| 7 | Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart显示文摘Chronic hyperglycemia is one of the main characteristics of diabetes. Persistent exposure to elevated glucose levels has been recognized as one of the major causal factors of diabetic complications. In pathologies, like type 2 diabetes mellitus(T2DM), mechanical and biochemical stimuli activate profibrotic signaling cascades resulting in myocardial fibrosis and subsequent impaired cardiac performance due to ventricular stiffness. High levels of glucose nonenzymatically react with long-lived proteins, such as collagen, to form advanced glycation end products(AGEs). AGE-modified collagen increase matrix stiffness making it resistant to hydrolytic turnover, resulting in an accumulation of extracellular matrix(ECM) proteins. AGEs account for many of the diabetic cardiovascular complications through their engagement of the receptor for AGE(RAGE). AGE/RAGE activation stimulates the secretion of numerous profibrotic growth factors, promotes increased collagen deposition leading to tissue fibrosis, as well as increased RAGE expression. To date, the AGE/RAGE cascade is not fully understood. In this review, we willdiscuss one of the major fibrotic signaling pathways, the AGE/RAGE signaling cascade, as well as propose an alternate pathway via Rap1 a that may offer insight into cardiovascular ECM remodeling in T2 DM. In a series of studies, we demonstrate a role for Rap1 a in the regulation of fibrosis and myofibroblast differentiation in isolated diabetic and non-diabetic fibroblasts. While these studies are still in a preliminary stage, inhibiting Rap1 a protein expression appears to down-regulate the molecular switch used to activate the ζ isotype of protein kinase C thereby promote AGE/RAGE-mediated fibrosis. | Jia Zhao Rushil Randive James A Stewart | 2014 | World Journal of Diabetes2014，5，6： | 17 |
| 8 | E2 enzymes: more than just middle men显示文摘 | Mikaela D Stewart Tobias Rltterhoff Rachel E Klevit Peter S Brzovic | 2016 | Cell Research2016，26，4： | 17 |
| 9 | 子宫颈癌筛查异常妇女处理的共识指南(2006版)显示文摘2001年,美国阴道镜与宫颈病理学会(American Society for Colposcopyand Cervical Pathology,ASCCP)联合其他专业学会以及联邦与国际组织.制订了2001版的宫颈癌细胞学筛查结果异常妇女处理的共识指南。这是全面的、以循证医学为依据的指南,其目的是帮助所有亚专业的临床医生,处理每年约480万诊断为细胞学异常的美国妇女。 | 李志刚(翻译) Thomas C. Wright Jr L Stewart Massad Charles J. Dunton MarkSpitzer Edward J. Wilkinson DianeSolomon | 2008 | 循证医学2008，8，4： | 16 |
| 10 | 环境DNA及其在水生生态系统保护中的应用显示文摘环境DNA(environmental DNA,e DNA)是指可以从环境样品(如水、土壤、空气、冰芯等)中直接提取到的DNA片段总和。e DNA技术是在确定调查物种或种群的特异性基因识别片段的基础上,利用各种分子手段检测从环境介质中所提取e DNA包含识别片段的情况,进而确定取样环境中生物的分布状况,包括e DNA获取、e DNA分析和结果分析3个阶段,是近年来新出现的一种生物调查方法。与传统方法相比,e DNA技术具有灵敏度高、省时省力、对调查对象无损伤等优点,不要求调查者具有传统的生物识别及鉴定经验。目前e DNA技术已被应用于目标物种(如入侵物种、濒危物种及其他稀有物种)'有无'的检测、生物量的估测、水体生物多样性的调查等,在水生生态系统的保护中具有广泛的应用前景,但目前仅在少数发达国家展开应用,亟待进一步推广。目前研究者们所用的e DNA方法各不相同,有待对现有方法进行完善并建立技术标准;作为一种调查方法,其时间及空间精确度有待进一步评价;利用e DNA技术估测生物量的准确度还较低,建议首先提高对e DNA产生与降解动力学的认识,再进一步寻求提高其准确度的方法。 | 马鸿娟 STEWART Kathryn 马利民 任文伟 赵建夫 | 2016 | 生态学杂志2016，35，2： | 16 |
| 11 | Blood pressure,prevalence of hypertension and hypertension related complications in Nigerian Africans:A review显示文摘To review studies on hypertension in Nigeria over the past five decades in terms of prevalence,awareness and treatment and complications.Following our search on Pubmed,African Journals Online and the World Health Organization Global cardiovascular infobase,1060 related references were identified out of which 43 were found to be relevant for this review.The overall prevalence of hypertension in Nigeria ranges from 8%-46.4% depending on the study target population,type of measurement and cut-off value used for defining hypertension.The prevalence is similar in men and women(7.9%-50.2% vs 3.5%-68.8%,respectively) and in the urban(8.1%-42.0%) and rural setting(13.5%-46.4%).The pooled prevalence increased from 8.6% from the only study during the period from 1970-1979 to 22.5%(2000-2011).Awareness,treatment and control of hypertension were generally low with attendant high burden of hypertension related complications.In order to improve outcomes of cardiovascular disease in Africans,public health education to improve awareness of hypertension is required.Further epidemiological studies on hypertension are required to adequately understand and characterize the impact of hypertension in society. | Okechukwu S Ogah Ikechi Okpechi Innocent I Chukwuonye Joshua O Akinyemi Basden JC Onwubere Ayodele O Falase Simon Stewart Karen Sliwa | 2012 | World Journal of Cardiology2012，4，12： | 13 |
| 12 | 暗娼人群生存状况的定性调查显示文摘目的 了解暗娼人群的生存状况 ,为实施有效的性病艾滋病干预措施提供依据。方法 采用小组访谈和个人深入访谈相结合 ,逐步深入的社会学调查方法 ,在四川和云南省的 6个地区分别抽取 90名和 91名暗娼进行小组访谈 ,抽取 13 5和 156名暗娼进行个人深入访谈。结果 暗娼年龄多在 18~ 3 0岁之间 ,以初中文化为主 ,多数未婚 ,来自外地 ;暗娼人群社会经济地位普遍较低 ,最关心和最常谈论的话题是如何挣钱 ,如何穿着打扮及玩耍等 ;暗娼之间很少有交流待客经验和交流使用安全套经验及防病知识的情况 ;性行为的主要方式是阴道交 ,很少有人每次性行为都坚持使用安全套 ,暗娼对性病艾滋病的预防方法还存在错误认识 ;暗娼中存在吸毒行为 ,其中多数 (4/ 5)与他人共用注射器吸毒的行为。结论 在性病艾滋病健康教育工作中 ,应把文化较低的外来打工妹和无业闲杂人员作为干预重点 ;在向暗娼人群灌输正确性病艾滋病预防知识的同时 。 | 陈虹 程峰 栾荣生 胡虹 张灵麟 万绍平 杨志伟 William stewart 沈洁 | 2003 | 中国公共卫生2003，19，12： | 11 |
| 13 | R 2 around the world: New theory and new tests显示文摘 | Li Jin Stewart C. Myers | 2005 | Journal of Financial Economics2005，，2： | 11 |
| 14 | Spatial correlations between urbanization and river water pollution in the heavily polluted area of Taihu Lake Basin, China显示文摘在泰胡·莱克盆的水污染很长时间是在中国和国外的注意的焦点,由于它在在中国的城市的开发的最前线的位置。在数据从 84 聚在一起并且处理上基于在这个重重地弄脏的区域监视节,这研究首先分析都市化的空间模式和河水的分发污染,然后使用 GeoDa bivariate 在镇区单位的规模调查在都市化和河水污染之间的空间关联的空间自相关模型。结果证明都市化在水污染上有不利影响,并且影响在发展区域的不同层次变化。城市的镇区单位有都市化和最高的污染的高水平,但是最好的水质量;郊外的单位有都市化,而是更高的污染和更坏的水质量的底层;然而,农村单位有都市化和最低污染的底层,主要由在上游的污染,而是最糟的水质量影响了。最后,当活跃地在这个区域支持开发的进程时,城市、农村的计划委员会应该逐渐地解决落后于城市的生活和城市的开发的污染控制的问题,在农村区域和郊外的区域把优先级给集中的污水处理设备和联系管道网络范围的建设。 | 赵海霞 段学军 Becky STEWART 尤本胜 蒋晓威 | 2013 | Journal of Geographical Sciences2013，23，4： | 10 |
| 15 | 法庭说话人识别语音数据库的构建显示文摘为建立具有代表性的法庭话者识别相关背景人群语音数据库,促进法庭语音数据的资源共享,从法庭话者识别的研究和实践出发,提出了一套基于汉语的法庭语音数据库构建方案,对语音数据的采集、处理和应用也提出了相关建议。这样的数据库更贴近典型案件条件,更适合法庭语音研究及应用,也适合其他自然口语语音研究。 | 张翠玲 Geoffrey Stewart Morrison | 2016 | 中国刑警学院学报2016，，4： | 9 |
| 16 | 云南和四川部分地区吸毒人群的性病艾滋病防治需求评估的定性研究显示文摘目的 :了解目标地区吸毒人群的性病艾滋病防治需求 ,为制定符合当地的有效干预措施提供科学依据和建议。方法 :2 0 0 1年 3月 - 2 0 0 2年 4月 ,采用《性健康需求评估》实施方案中的定性访谈方法 ,分别在云南、四川选取大、中、小 6个试点地区 ,对当地吸毒人群进行深入访谈。每个地区分别对 5名市 /县 /区 /社区公安部门的关键人物进行定性访谈 ,每个点对 10名吸毒者的家庭成员进行个别访谈。结果 :(1)两省部分地区的吸毒者绝大部分使用的毒品为海洛因 ,其中有相当一部分人合并多药滥用 ,大城市较中、小城市严重 ;(2 )在注射毒品者中普遍存在共用注射器的状况。但不同地区共用注射器的比例有所不同 ;(3)注射器来源主要是私人诊所和药店 ;(4 )相当数量的注射毒品者不知道如何正确消毒注射器 ;(5 )不同地区的吸毒者均有不同程度的不安全性行为 ;(6 )社会歧视和耻辱感是导致戒毒后复吸率高的重要因素之一 ,也是阻碍开展降低危害工作的重要社会文化因素。结论 :通过开展针对目标人群的性健康需求评估 ,可为当地开展有针对性的干预工作提供方向、方法以及接触目标人群的方法与途径。性健康需求评估为研究与干预搭建桥梁。 | 陈虹 程峰 李建华 张灵麟 胡虹 张建新 程何荷 万绍平 张勇 杨志伟 William Stewart 沈洁 | 2004 | 中国药物依赖性杂志2004，13，2： | 9 |
| 17 | Applicability of five models to simulate water infiltration into soil with added biochar显示文摘As a soil amendment, biochar can reduce soil bulk density, increase soil porosity, and alter soil aggregates and thus affect the infiltration. Researchers have proposed and revised several theoretical models to describe the process of soil infiltration. Although these models have been successfully used to evaluate the soil infiltration in different scenarios in agricultural fields, little effort has been devoted to assess their performances in arid and semi-arid soils after the addition of biochar. A laboratory experiment was performed to study the infiltration characteristics of two typical Loess Plateau soils at three particle sizes(2–1, 1–0.25, and <0.25 mm) and five biochar application amounts(0, 10, 50, 100, and 150 g/kg). The performance of five models(i.e., the Philip model, Kostiakov model, Mezencev model, USDA-NRCS model, and Horton model) in simulating the infiltration process was then evaluated based on the adjusted coefficient of determination and a reduced Chi-Square test. Results indicated that the Horton model best simulated the water-infiltration process in an aeolian sandy soil with added biochar. However, the Mezencev model best simulated the infiltration process in a loamy clay soil(Eum-Orthic Anthrosol). The three-parameter model, i.e., Mezencev and Horton models can better describe the relationship between cumulative infiltration and infiltration time. In conclusion, biochar reduced the soil infiltration capacity of the aeolian sandy soil and increased that of the Eum-Orthic Anthrosol. | WANG Tongtong Catherine E STEWART MA Jiangbo ZHENG Jiyong ZHANG Xingchang | 2017 | Journal of Arid Land2017，9，5： | 9 |
| 18 | Anti-diabetic vanadyl complexes reduced Alzheimer's disease pathology independent of amyloid plaque deposition显示文摘Association of Alzheimer's disease(AD) with cerebral glucose hypometabolism, likely due to impairments of insulin signaling,has been reported recently, with encouraging results when additional insulin is provided to AD patients. Here, we tested the potential effects of the anti-diabetic vanadium, vanadyl(IV) acetylacetonate(VAC), on AD in vitro and in vivo models. The experimental results showed that VAC at sub-micromolar concentrations improved the viability of neural cells with or without increased β-amyloid(Aβ) burden; and in APP/PS1 transgenic mice, VAC treatment(0.1 mmol kg-1 d-1) preserved cognitive function and attenuated neuron loss, but did not reduce brain Aβ plaques. Further studies revealed that VAC attenuated Aβpathogenesis by(i) activation of the PPARγ-AMPK signal transduction pathway, leading to improved glucose and energy metabolism;(ii) up-regulation of the expression of glucose-regulated protein 75(Grp75), thus suppressing p53-mediated neuronal apoptosis under Aβ-related stresses; and(iii) decreasing toxic soluble Aβ peptides. Overall, our work suggested that vanadyl complexes may have great potential for effective therapeutic treatment of AD. | Yaqiong Dong TessANDra Stewart Yue Zhang Min Shi Chang Tan Xue Li Lan Yuan Aanchal Mehrotra Jing Zhang Xiaoda Yang | 2019 | Science China(Life Sciences)2019，62，1： | 8 |
| 19 | The cytokine milieu in the interplay of pathogenic Th1/ Th17 cells and regulatory T cells in autoimmune disease显示文摘The propagation and regulation of an immune response is driven by a network of effector and regulatory T(Treg)cells.The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution in an autoimmune disease setting.In autoimmune diseases,this interplay shifts the balance in favor of the development of autoreactive effector T cells,resulting in inflammatory pathology.The objective of an effective therapeutic approach for autoimmune disease is to restore this balance.In this review,we describe the characteristics and development of pathogenic T helper 1(Th1)and Th17 cells and the beneficial Treg cells in autoimmune diseases and the crucial roles of the cytokine milieu in influencing the balance of these T-cell subsets.Given the importance of cytokines,we discuss current immunotherapeutic strategies using cytokine or cytokine receptor antibodies for the treatment of autoimmune diseases. | Stewart Leung Xuebin Liu Lei Fang Xi Chen Taylor Guo Jingwu Zhang | 2010 | Cellular & Molecular Immunology2010，7，3： | 8 |
| 20 | 两种单氟磷酸钠牙膏预防乳牙龋病的2年临床研究显示文摘目的 :比较含氟浓度为 78.95 mmol/L (15 0 0 ppm)、磨料分别为碳酸钙及二氧化硅的二种单氟磷酸钠牙膏对儿童乳牙的临床防龋效果。方法 :采用随机双盲对照法 ,对四川省成都市 12 0 0名 4岁儿童进行了为期 2年的追踪研究。受试儿童被分为 3组 ,第 l组为含氟浓度 78.95 mmol/L、磨料为二氧化硅的单氟磷酸钠牙膏(MFP/Si O2 ) ,第 2组为含氟浓度 78.95 mmol/L、磨料为碳酸钙的单氟磷酸钠牙膏 (MFP/Ca CO3) ,第 3组为对照组 ,使用不含氟的碳酸钙牙膏。分析指标为乳牙龋面均 (dfs)增长数。结果 :998名儿童完成 2年的临床观察 ,1基线检查 3组的龋面均无显著性差异 ;2 l年后的龋面均增长数 :MFP/Si O2 组为 1.6 9± 3.12 ,MFP/Ca CO3组为1.5 3± 3.0 9,与对照组 2 .19± 4.12比较分别下降 30 .1%和 2 2 .8% ;3 2年后 MFP/Si O2 组和 MFP/Ca CO3组的龋面均增长数为 2 .98± 4.42及 2 .75± 4.33,与对照组 4.73± 5 .17比较分别下降 37%和 41.9% ,差异有显著性 ,两试验组之间统计学的差异无显著性。结论 :使用含 78.95 mmol/L氟浓度 ,磨料为二氧化硅或碳酸钙的单氟磷酸钠牙膏均有明显防龋效果 ,只要严格控制含氟牙膏的用量和加强管理 ,对发病率高的幼儿乳牙 ,不失为一种值得推广的安全而有效的防龋措施。 | 范旭 万呼春 胡德渝 Yun PoZhang Bernal Stewart James McCool Margaret Petrone William De Vizio Anthony Volpe | 2001 | 实用口腔医学杂志2001，17，6： | 8 |
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