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| 1 | Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system显示文摘加入的 Nonhomologous 脱氧核糖核酸结束(NHEJ ) 是为在人的房间并且在多细胞的优核质的双海滨脱氧核糖核酸裂缝的修理的主要小径。双海滨裂缝的原因经常碎裂在损坏的地点的脱氧核糖核酸,导致在那里的信息的损失。NHEJ 不恢复失去的信息并且可以将切除另外的核苷酸在修理过程期间。修理大量 overhang 并且损坏配置的能力反映 NHEJ 的核酸酶,聚合酶,和连接酶的灵活性。单个部件的灵活性也解释 NHEJ 能在修理脱氧核糖核酸结束的任何给定的对的方法的大数字。局部地,在 NHEJ 的地点,修理可以贡献癌症和老化的信息的损失,而是由 NHEJ 的行动保证染色体的全部片断没被失去。 | Michael R Lieber Haihui Lu Jiafeng Gu Klaus Schwarz | 2008 | Cell Research2008，18，1： | 5 |
| 2 | 嵌合型E1B55-kDa蛋白缺陷型腺病毒载体治疗肿瘤的评价(英文)显示文摘ONYX-015和H101为可复制E1B55-kDa蛋白缺陷的C族腺病毒,它们正作为抗癌药物进行临床研究.然而它们在癌症基因治疗中的应用却受到了C族腺病毒天然特性的制约,部分原因是由于在恶性肿瘤中C族腺病毒受体(coxsackievirus-adenovirusreceptor,CAR)的表达量较低.构建了一个以H101为骨架的含有编码35型腺病毒鞭毛区域的基因,替代5型腺病毒鞭毛基因的嵌合型腺病毒载体.这一改动使得腺病毒载体可以通过一种在肿瘤中高表达的膜蛋白CD46感染肿瘤细胞.应用RT-PCR方法检测不同肿瘤细胞株中CAR和CD46表达量的区别.在CAR受体低表达的细胞株中(MDA-MB-435和MCF-7),H101-F35表现出比H101和ONYX-015更强的细胞杀伤效果;在CAR受体高表达的细胞株中(A549,NCI-H446,Hep3B,LNCaP,ZR-75-30和Bcap-37),H101-F35、H101和ONYX-015的细胞杀伤效果则相似.在荷MDA-MB-435肿瘤的裸鼠模型中,注射H101-F35的抑瘤效果比注射H101的抑瘤效果更明显.这些结果表明嵌合型溶瘤腺病毒载体H101-F35在肿瘤基因治疗中将有很好的应用前景. | 叶迅 陆琴 赵毅 任臻 孟夏 葛盛芳 邱祺宏 童涌 LIEBER ANDRE 梁旻 胡放 陈红专 | 2005 | 生物化学与生物物理进展2005，32，12： | 5 |
| 3 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 4 | Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis显示文摘 | Charles S. Lieber | 2005 | Alcohol2005，，1： | 2 |
| 5 | Perioperative glucose management and outcomes in liver transplant recipients: A qualitative systematic review显示文摘AIM To investigate the relationship between post-liver transplantation(LT) glycemic control and LT outcomes. METHODS A qualitative systematic review on relevant prospective interventions designed to control glucose levels including insulin protocols. Studies investigating an association between glycemic control and post-LT outcomes such as mortality, graft rejection, and infection rate were reviewed. Pub Med, EMBASE, and other databases were searched through October 2016. RESULTS Three thousands, six hundreds and ninety-two patients from 14 studies were included. Higher mortality rate was seen when blood glucose(BG) ≥ 150 mg/dL(P = 0.05). BG ≥ 150 mg/dL also led to higher rates of infection. Higher rates of graft rejection were seen at BG > 200 mg/dL(P < 0.001). Mean BG ≥ 200 mg/dL was associated with more infections(P = 0.002).Nurse-initiated protocols and early screening strategies have shown a reduction in negative post-LT outcomes.CONCLUSION Hyperglycemia in the perioperative period is associated with poor post-LT outcomes. Only a few prospective studies have designed interventions aimed at managing post-LT hyperglycemia, post-transplant diabetes mellitus(PTDM) and their impact on post-LT outcomes. | Prani Paka Sarah R Lieber Ruth-Ann Lee Chirag S Desai Robert E Dupuis Alfred Sidney Barritt | 2018 | World Journal of Transplantation2018，8，3： | 2 |
| 6 | A laser ablation method for the synthesis of crystalline semiconductor nanowires显示文摘 | Morales A M Lieber C M | 1998 | Science1998，279，： | 2 |
| 7 | Nanobeam mechanics: Elasticity, strength, and toughness of nanorods and nanotubes显示文摘 | Sheehan P E Lieber C M | 1997 | Science1997，，277： | 1 |
| 8 | Dilinoleoylphosphatidylcholine decreases ethanol-induced cytechrome P4502E1显示文摘 | ALEYNIK M K LIEBER CS | 2001 | Biochem Biophys Res Commun2001，288，4： | 1 |
| 9 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway显示文摘 | Lieber MR | 2010 | Annu Rev Biochem2010，79，7： | 1 |
| 10 | Functional nanoscale electronic devices assembled using silicon nanowire buliding blocks显示文摘 | Cui Y Lieber C M | 2001 | Science2001，291，5505： | 1 |
| 11 | Funtional nanoscale electronic devices assembled using silicon nanowire building blocks显示文摘 | Cui Y Lieber C M | 2001 | Science2001，291，： | 1 |
| 12 | ATT Filament Winding Technology显示文摘 | D Noss R Lieber | 2002 | Chemical Fibers International2002，52，6： | 1 |
| 13 | Chemistry and physics in one dimension:synthesis and properties of nanowires and nanotubes显示文摘 | HU J ODOM T W LIEBER C M | 1999 | Acc Chem Res1999，32，： | 1 |
| 14 | Prevention and treatment of liver fibrosis based on pathogenesis显示文摘 | Lieber CS | 1999 | Alcohol Clin Exp Res1999，23，： | 1 |
| 15 | Formation processes of silica nanotubes through a surfactant-assisted templating mechanism in laurylamine hydrochloride/tetraethoxysilane system 显示文摘 | Dai H Wong E W Lieber C M | 1995 | Nature1995，375，6534： | 1 |
| 16 | Alteration of hemodynamics in aneurysm models by stenting: Influence of stent porosity显示文摘 | Lieber BB Stancampiano AP Wakhloo AK | 1997 | Ann Biomed Eng1997，25，： | 1 |
| 17 | MgO nanostmctures synthe- sized by thermal evaporation显示文摘 | Yang P D Lieber C M | 1997 | Mater Res1997，12，： | 1 |
| 18 | Model of nonalcoholic steatohepstitis显示文摘 | Lieber CS Leo MA Mak KM | | 0，，03： | 1 |
| 19 | Role of oxidative stress and antioxidant theropy inaleoholi and nonaleoholie liver disease 显示文摘 | Lieber CS | 1997 | Adv Pharmacol1997，38，6： | 1 |
| 20 | Surgical management of aberrant sentinel lymph node drainage in cutaneous melanoma显示文摘 | Standiford SB Kuvshinoff BW | 1998 | Surgery1998，124，： | 1 |
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