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| 1 | Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin显示文摘For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune response.Flagellin is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical application.Calcium phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and proteins.Flagellin-functionalized calcium phosphate nanoparticles were prepared and their immunostimuiatory effect on the innate immune system,i.e.the cytokine production,was studied.They induced the production of the proinflammatory cytokines IL-8(Caco-2 cells) and IL-1β(bone marrow-derived macrophages;BMDM) in vitro and IL-6 in vivo after intraperitoneal injection in mice.The immunostimulation was more pronounced than with free flagellin. | Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer Astrid Maria Westendorf Matthias Epple Huimin Yan | 2014 | Virologica Sinica2014，29，1： | 3 |
| 2 | Physiological variation related to shell colour polymorphism in White Sea Littorina saxatilis显示文摘 | I.M Sokolova V.Ja Berger | 2000 | Journal of Experimental Marine Biology and Ecology2000，，1： | 2 |
| 3 | 金属污染和海洋酸化对海洋生物生理的影响显示文摘在全球环境中的变化,如海洋酸化(办公自动化)可能会影响人类的污染物,包括微量金属,威胁到海洋生态系统的完整性。我们分析最近的研究,对海洋生物的相互作用的影响,对海洋生物的相互作用,这些相互作用的生理基础。我们的分析表明,CO2和金属高温反应强烈依赖于物种,发育阶段,金属生物化学和环境的高碳酸血症的程度,并不能直接从CO2引起的金属溶解性和形态变化预测。通过OA和微量金属暴露影响的关键生理功能涉及酸碱调节,亲蛋白周转和线粒体能量,反映其细胞和分子途径的CO2和金属的敏感性。生理作用下二氧化碳和金属之间的相互作用可能会影响生物体的能力,以保持交流-身份证的基本平衡,并减少能量可用于健身相关的功能,如生长,发展和重新生产,从而影响生存和河口种群的性能。也可以通过改变环境的高碳酸血症的捕食作用和食物链的金属传输影响海洋食物网。然而,我们在这一程度上,这些影响可以影响海洋生态系统的功能和完整性是有限的,由于疤痕-城市发表的研究和对某些分类群的偏见。今后的研究重点应包括金属X pCO2的相互作用的研究聚焦于关键的生理功能(包括酸碱,蛋白质和能量平衡)在更大范围的生态和经济上重要的海洋物种,以及包括田间种群自然前合影(和潜在的改编)在不同层次的环境[当前生态61金属和CO2(4):653-668,2015 ]。 | Anna V. Ivanina Inna M. Sokolova | 2015 | Current Zoology2015，61，4： | 2 |
| 4 | Effective trans fection of ceils with multi shell calcium phosphate-DNA nano- particles显示文摘 | Sokolova V V Radtke I Heumann R | 2006 | Biomarerials2006，27，16： | 1 |
| 5 | Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family 显示文摘 | Sokolova IM Sokolov EP | 2005 | FEBS Lett2005，579，： | 1 |
| 6 | A comparison of cytolo-gy and fluorescence in situ hybridization for the detection of urothe-lial carcinoma显示文摘 | Hailing K C King W Sokolova I A ef al | 2000 | J Urol2000，164，5： | 1 |
| 7 | The development of a multitarget,multicolor fluo- rescence in situ hybridization assay {or the detection of urothelial carcinoma in urine显示文摘 | SOKOLOVA I A HALLING K C JENKINS R B | 2000 | J Mol Diagn2000，2，： | 1 |
| 8 | miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation显示文摘 | Reid JF Sokolova V Zoni E | 2012 | Mol Cancer Res2012，10，4： | 1 |
| 9 | Effectsof5-(N-ethyl-Nisopropyl)amiloride(EIPA)ondifferentpatternsofepileptiformactivityinrattemporalcortexslices显示文摘 | SokolovaS ZhangCL ArensJ etal | 1992 | NeurosciResCommun1992，10，： | 1 |
| 10 | Frequency dispersion of the interfacial impedance at mild steel corrosion in acid media in the presence of benzimidazole derivatives显示文摘 | A Popova S Raicheva E Sokolova | 1996 | Langmuir1996，12，： | 1 |
| 11 | Physiological variation related to shell color polymorphism in White Sea Littorina saxatilis 显示文摘 | Sokolova I M Berger V J | 2000 | J Exp Mar Bio Eco2000，245，： | 1 |
| 12 | Polyakovite-(Ce) , ( REE, Ca) 4 ( Mg, Fe^2+) ( Cr, Fe^3+) 2 ( Ti, Nb) 2 Si4O22, a new metamict mineral species from the Ilmen Mountains, Russia: Mineral description and crystal chemistry显示文摘 | Popov V A Pautov L A Sokolova E | 2001 | Can Mineral2001，39，： | 1 |
| 13 | The phylogenetie diversity of aerobic organotrophie bacteria from the Dagang high- temperature oil field显示文摘 | Nazina T N Sokolova D Sh Shestakova N M | 2005 | Microbiology2005，74，3： | 1 |
| 14 | Meionite:Rietveld structure-refinement,29Si MAS and 27Al satras NMR spectroscopy,and comments on the marialite-meionite series显示文摘 | Sherriff B L Sokolova E V Kabalov R K | 2000 | The Canadian Mineralogist2000，38，： | 1 |
| 15 | Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease显示文摘 | Sokolova A Hill MD Rahimi F | 2009 | Brain Pathol2009，19，3： | 1 |
| 16 | Topamax monotherapy of partial epilepsy显示文摘 | KALININ VV ZHELEZNOVA EV SOKOLOVA LV | 2004 | Zh Nevropatol Psikhiatr2004，104，7： | 1 |
| 17 | Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition显示文摘 | Sokolova IM Evans S Hughes FM | 2004 | J Exp Biol2004，207，19： | 1 |
| 18 | Concave diffraction gratings recorded in counterpropagating beams显示文摘 | E A Sokolova | 1999 | Opt Technol1999，66，12： | 1 |
| 19 | Adsorption and inhibitive properties of benzimidazole derivatives in acid mild steel corrosion显示文摘 | A Popova M Christov S Raicheva E Sokolova | 2003 | Corrosion Science2003，，6： | 1 |
| 20 | PRIMUS: a Windows PC-based system for small-angle scattering data analysis显示文摘 | Konarev PV Volkov VV Sokolova AV | 2003 | J Appl Cryst2003，36，5： | 1 |
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