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| 1 | Recent progresses in mangrove conservation,restoration and research in China显示文摘Aims In this paper,we highlighted some key progresses in mangrove conservation,restoration and research in China during last two decades.Methods Based on intensive literature review,we compared the distribution and areas of existing mangroves among selected provinces of China,discussed the issues associated with mangrove conservation and restoration and highlighted major progresses on mangrove research conducted by key institutions or universities in China's Mainland,Hong Kong,Taiwan and Macao.Important findings The population boom and rapid economic developments have greatly reduced mangrove areas in China since 1980s,leaving only 22700 ha mangroves in China's Mainland in 2001.Chinese government has launched a series of programs to protect mangroves since 1980s and has established mangrove ecosystems as high-priority areas for improving environmental and living resource management.During last three decades,a total of 34 natural mangrove conservation areas have been established,which accounts for 80%of the total existing mangroves areas in China.Mangrove restoration areas in China' Mainland accounted for<7%of the total mangroves areas in 2002.A great deal of research papers on Chinese mangroves has been published in international journals.However,more systematic protection strategies and active restoration measurements are still urgently needed in order to preserve these valuable resources in China. | Luzhen Chen Wenqing Wang Yihui Zhang Guanghui Lin | 2009 | Journal of Plant Ecology2009，2，2： | 42 |
| 2 | Responses of soil respiration to simulated precipitation pulses in semiarid steppe under different grazing regimes显示文摘Aims Precipitation pulses and different land use practices(such as grazing)play important roles in regulating soil respiration and carbon balance of semiarid steppe ecosystems in Inner Mongolia.However,the interactive effects of grazing and rain event magnitude on soil respiration of steppe ecosystems are still unknown.We conducted a manipulative experiment with simulated precipitation pulses in Inner Mongolia steppe to study the possible responses of soil respiration to different precipitation pulse sizes and to examine how grazing may affect the responses of soil respiration to precipitation pulses.Methods Six water treatments with different precipitation pulse sizes(0,5,10,25,50 and 100 mm)were conducted in the ungrazed and grazed sites,respectively.Variation patterns of soil respiration of each treatment were determined continuously after the water addition treatments.Important Findings Rapid and substantial increases in soil respiration occurred 1 day after the water treatments in both sites,and the magnitude and duration of the increase in soil respiration depended on pulse size.Significantly positive relationships between the soil respiration and soil moisture in both sites suggested that soil moisture was the most important factor responsible for soil respiration rate during rain pulse events.The ungrazed site maintained significantly higher soil moisture for a longer time,which was the reason that the soil respiration in the ungrazed site was maintained relatively higher rate and longer period than that in the grazed site after a rain event.The significant exponential relationship between soil temperature and soil respiration was found only in the plots with the high water addition treatments(50 and 100 mm).Lower capacity of soil water holding and lower temperature sensitivity of soil respiration in the grazed site indicated that degraded steppe due to grazing might release less CO_(2) to the atmosphere through soil respiration under future precipitation and temperature scenarios. | Shiping Chen Guanghui Lin Jianhui Huang Mao He | 2008 | Journal of Plant Ecology2008，1，4： | 24 |
| 3 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 4 | Methylmercury and sulfate-reducing bacteria in mangrove sediments from Jiulong River Estuary,China显示文摘Estuaries are important sites for mercury (Hg) methylation,with sulfate-reducing bacteria (SRB) thought to be the main Hg methylators.Distributions of total mercury (THg) and methylmercury (MeHg) in mangrove sediment and sediment core from Jiulong River Estuary Provincial Mangrove Reserve,China were determined and the possible mechanisms of Hg methylation and their controlling factors in mangrove sediments were investigated.Microbiological and geochemical parameters were also determined.Results showed that SRB constitute a small fraction of total bacteria (TB) in both surface sediments and the profile of sediments.The content of THg,MeHg,TB,and SRB were (350±150)ng/g,(0.47±0.11)ng/g,(1.4×10 11±4.1×109)cfu/g dry weight (dw),and (5.0×106±2.7×106)cfu/g dw in surficial sediments,respectively,and (240±24)ng/g,(0.30±0.15)ng/g,(1.9×1011± 4.2×1010)cfu/g dw,and (1.3×106± 2.0×106) cfu/g dw in sediment core,respectively.Results showed that THg,MeHg,TB,MeHg/THg,salinity and total sulfur (TS) increased with depth,but total organic matter (TOM),SRB,and pH decreased with depth.Concentrations of MeHg in sediments showed significant positive correlation with THg,salinity,TS,and MeHg/THg,and significant negative correlation with SRB,TOM,and pH.It was concluded that other microbes,rather than SRB,may also act as main Hg methylators in mangrove sediments. | Hao Wu Zhenhua Ding Yang Liu Jinling Liu Haiyu Yan Jiayong Pan Liuqiang Li Huina Lin Guanghui Lin Haoliang Lu | 2011 | Journal of Environmental Sciences2011，23，1： | 17 |
| 5 | Model and Algorithm for the Optimal Controlled Partitioning of Power Systems显示文摘解列是电力系统在故障时结构完整性得不到保证的情况下分裂为2个或多个孤立稳定运行子系统的过程或操作。及时恰当的主动解列操作将能有效地避免因保护连锁动作使得电力系统被动解列而崩溃所造成的巨额经济损失。结合图论中的相关概念和输电网最优解列的物理过程,建立电力系统最优主动解列断面选择问题的完整数学模型,并基于含连通图约束的背包问题(connected graph constrained knapsack problem,CGKP)及其求解算法提出“搜索+调整”的2阶段求解方法。为降低问题的复杂性,将完整数学模型分解成图的最优平衡分割问题和基于优化潮流的调节问题,并分2个阶段分别求解。其中,图的最优平衡分割问题又被分解成多个CGKP,利用基于含CGKP的图分割方法进行求解。所提出的主动解列策略具有较强理论基础,计算复杂度低,算例的计算结果证明了该模型及算法的正确性和有效性。 | LIN Jikeng LI Shengwen WU Peng WANG Xudong SHAO Guanghui XU Xingwei MA Xin | 2012 | 中国电机工程学报2012，32，13： | 15 |
| 6 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 7 | Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death显示文摘Objective: Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. Methods: Comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins' expression and location. Results: Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. Conclusions: Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC. | Yang Xu Guanghui Wang Quancheng Chen Ting Lin Zhiping Zeng Qiang Luo Jie Liu Cuiling Sun | 2013 | Chinese Journal of Cancer Research2013，25，3： | 12 |
| 8 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 9 | On-chip photonic Fourier transform with surface plasmon polaritons显示文摘The Fourier transform(FT),a cornerstone of optical processing,enables rapid evaluation of fundamental mathematical operations,such as derivatives and integrals.Conventionally,a converging lens performs an optical FT in free space when light passes through it.The speed of the transformation is limited by the thickness and the focal length of the lens.By using the wave nature of surface plasmon polaritons(SPPs),here we demonstrate that the FT can be implemented in a planar configuration with a minimal propagation distance of around 10 mm,resulting in an increase of speed by four to five orders of magnitude.The photonic FT was tested by synthesizing intricate SPP waves with their Fourier components.The reduced dimensionality in the minuscule device allows the future development of an ultrafast on-chip photonic information processing platform for large-scale optical computing. | Shan Shan Kou Guanghui Yuan Qian Wang Luping Du Eugeniu Balaur Daohua Zhang Dingyuan Tang Brian Abbey Xiao-Cong Yuan Jiao Lin | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 10 | Applications of Light Stable Isotopes(C, O, H) in the Study of Sandstone Diagenesis: A Review显示文摘This article reviews the applications of light stable isotope, including carbon, oxygen and hydrogen, in thestudies on origin and formation temperature of authigenic carbonate, quartz and clay minerals. Theoretical knowledge andanalytical methods for major light stable isotopes are introduced in detail. Negative and positive δ^(13)C values indicatesignificant differences on the origin of carbonate cements. The δ^(18)O value is an effective palaeotemperature scale forauthigenic minerals formation. Various fractionation equations between δ^(18)O and temperature are proposed for carbonatecements, quartz cements and clay minerals, whose merit and demerit, applicable conditions are clarified clearly. Clumpedisotope analysis can reconstruct the temperature of carbonate precipitation with no requirement on the δ^(18)O of initial waters,which makes temperature calculation of carbonate cements formation more convenient and accurate. Hydrogen and oxygenisotopes mainly reflect the origin of diagenetic fluid for clay mineral formation, providing reliable evidence for diageneticenvironment analysis. This work aims at helping researchers for better understanding the applications of light stable isotopein sandstone diagenesis. | XI Kelai CAO Yingchang LIN Miruo LIU Keyu WU Songtao YUAN Guanghui YANG Tian | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 4 |
| 11 | Angular-based spatially resolved laser-induced breakdown spectroscopy: a new technique for the effective enhancement of signals without an external time delay system显示文摘In this study, we developed a novel angularbased spatially resolved laser-induced breakdown spectroscopy(ABSR-LIBS) technique. This new method allows the spatially resolved spectroscopic properties of laserinduced plasma to be investigated using different angles and polar distances with a spatially adjustable fiber optics probe. The experimental evaluations suggested that the intensity of the Al signal distributions in the ‘‘side-view''depended greatly on the angle of the collection probe. The location of a collection probe at 50° would facilitate efficient spectral collection and minimize the disturbance of the plasma plume. The spectral signals in the plasma emissions had different distribution at various polar distances using the same collection angle, and the highest signal intensity was observed between 15 and 35 mm polar distances. This ABSR-LIBS technique improved both the LIBS signal and the maximum emission intensity of Al atoms by several times at the best spatial position in our experimental conditions. Furthermore, we successfully obtained well-resolved line emission spectroscopy signals without any external time delay using a nongated spectrometer based on the ABSR-LIBS system. We consider that the ABSR-LIBS technique has great potential for obtaining new insights with laser-induced plasma instruments and it could facilitate the development of a low-cost instrument. | Qingyu Lin Xu Wang Guanghui Niu Hongjun Lai Xiaoqin Zhu Kunping Liu Tao Xu Yixiang Duan | 2014 | Chinese Science Bulletin2014，59，27： | 3 |
| 12 | Poisson disk sampling through disk packing显示文摘Poisson disk sampling is an important problem in computer graphics and has a wide variety of applications in imaging, geometry, rendering, etc. In this paper, we propose a novel Poisson disk sampling algorithm based on disk packing. The key idea uses the observation that a relatively dense disk packing layout naturally satisfies the Poisson disk distribution property that each point is no closer to the others than a specified minimum distance, i.e., the Poisson disk radius. We use this property to propose a relaxation algorithm that achieves a good balance between the random and uniform properties needed for Poisson disk distributions. Our algorithm is easily adapted to image stippling by extending identical disk packing to unequal disks. Experimental results demonstrate the efficacy of our approaches. | Guanghui Liang Lin Lu Zhonggui Chen Chenglei Yang | 2015 | Computational Visual Media2015，1，1： | 3 |
| 13 | Genome-wide association study and genomic prediction of Fusarium ear rot resistance in tropical maize germplasm显示文摘Fusarium ear rot(FER)is a destructive maize fungal disease worldwide.In this study,three tropical maize populations consisting of 874 inbred lines were used to perform genomewide association study(GWAS)and genomic prediction(GP)analyses of FER resistance.Broad phenotypic variation and high heritability for FER were observed,although it was highly influenced by large genotype-by-environment interactions.In the 874 inbred lines,GWAS with general linear model(GLM)identified 3034 single-nucleotide polymorphisms(SNPs)significantly associated with FER resistance at the P-value threshold of 1×10^(-5),the average phenotypic variation explained(PVE)by these associations was 3%with a range from 2.33%to 6.92%,and 49 of these associations had PVE values greater than 5%.The GWAS analysis with mixed linear model(MLM)identified 19 significantly associated SNPs at the P-value threshold of 1×10^(-4),the average PVE of these associations was 1.60%with a range from 1.39%to 2.04%.Within each of the three populations,the number of significantly associated SNPs identified by GLM and MLM ranged from 25 to 41,and from 5 to 22,respectively.Overlapping SNP associations across populations were rare.A few stable genomic regions conferring FER resistance were identified,which located in bins 3.04/05,7.02/04,9.00/01,9.04,9.06/07,and 10.03/04.The genomic regions in bins 9.00/01 and 9.04 are new.GP produced moderate accuracies with genome-wide markers,and relatively high accuracies with SNP associations detected from GWAS.Moderate prediction accuracies were observed when the training and validation sets were closely related.These results implied that FER resistance in maize is controlled by minor QTL with small effects,and highly influenced by the genetic background of the populations studied.Genomic selection(GS)by incorporating SNP associations detected from GWAS is a promising tool for improving FER resistance in maize. | Yubo Liu Guanghui Hu Ao Zhang Alexander Loladze Yingxiong Hu Hui Wang Jingtao Qu Xuecai Zhang Michael Olsen Felix San Vicente Jose Crossa Feng Lin Boddupalli M.Prasanna | 2021 | The Crop Journal2021，9，2： | 3 |
| 14 | Seasonal and spatial variation in species diversity, abundance, and element accumulation capacities of macroalgae in mangrove forests of Zhanjiang, China显示文摘The objective of this study was to investigate whether there was distinctive seasonal and zonal variation in the species diversity, biomass, and element accumulation capacities of macroalgae in two major intertidal mangrove stand types(Avicennia marina assemblage and Sonneratia apetala assemblage) in the Zhanjiang region of southern China. Over a year, 31 species in 15 genera were identified in both mangrove assemblages, of which the dominant species were Cladophoropsis zollingeri and Enteromorpha clathrat. Macroalgal species were significantly most abundant in spring(p<0.05), followed by summer, winter, and autumn. Variation in the zonal distribution of macroalgal species was conspicuous in both intertidal mangrove assemblages, with the greatest abundance in the middle zone, and the least in the front zone. Patterns in the seasonal and zonal variation in macroalgal biomass in the S. apetala assemblage were similar to those of macroalgal species diversity in both mangrove assemblages. The seasonal patterns in tissue concentrations of 15 analyzed elements were not uniform among the macroalgae C. zollingeri, E. clathrata, and Gracilaria salicornia in the A. marina assemblage. All three species exhibited variation in their responses to ambient concentrations of different elements, implying their differential ability to absorb and selectively accumulate certain elements. | ZHANG Yubin LI Yuan SHI Fei SUN Xingli LIN Guanghui | 2014 | Acta Oceanologica Sinica2014，33，8： | 3 |
| 15 | Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G_1 cell cycle arrest and apoptosis: A quantitative proteomic study显示文摘Objective: The present study aimed to investigate the molecular events in alisol B 23-acetate(ABA) cytotoxic activity against a liver cancer cell line.Methods: First, we employed a quantitative proteomics approach based on stable isotope labeling by amino acids in cell culture(SILAC) to identify the different proteins expressed in HepG2 liver cancer cells upon exposure to ABA. Next, bioinformatics analyses through DAVID and STRING on-line tools were used to predict the pathways involved. Finally, we applied functional validation including cell cycle analysis and Western blotting for apoptosis and mTOR pathway-related proteins to confirm the bioinformatics predictions.Results: We identified 330 different proteins with the SILAC-based quantitative proteomics approach. The bioinformatics analysis and the functional validation revealed that the mTOR pathway, ribosome biogenesis, cell cycle, and apoptosis pathways were differentially regulated by ABA. G1 cell cycle arrest, apoptosis and mTOR inhibition were confirmed.Conclusions: ABA, a potential mTOR inhibitor, induces the disruption of ribosomal biogenesis. It also affects the mTOR-MRP axis to cause G1 cell cycle arrest and finally leads to cancer cell apoptosis. | Ji Xia Qiang Luo Shengbin Huang Fuquan Jiang Lin Wang Guanghui Wang Jingjing Xie Jie Liu Yang Xu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 2 |
| 16 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 17 | Shallow Genetic Structure of Pholis fangi in Bohai Sea and Yellow Sea Inferred from mt DNA Control Region显示文摘Pholis fangi is an ecologically important fish species inhabiting Chinese coastal waters of Yellow Sea and Bohai Sea. To investigate the genetic diversity and population genetic structure of P. fangi, a fragment of 487 bp in the first hypervariable region (HVR-1) of the mitochondrial DNA (mtDNA) control region was sequenced for 181 individuals collected from Bohai Sea and Yel- low Sea. A total of 18 polymorphic sites were detected, which defined 25 haplotypes. A moderate level of haplotype diversity (h = 0.7052) and a low level of nucleotide diversity (π= 0.0028) were detected. Both the phylogenetic tree and the haplotype network showed no significant genealogical structure difference among sampling locations. Pairwise FST comparison and hierarchical mo- lecular variance analysis (AMOVA) revealed that no significant genetic structure difference existed throughout the investigated re- gions, suggesting a high gene exchange among different populations. The results of neutrality test and mismatch distribution analysis indicated that a late Pleistocene population expansion (38000 127000 years ago) happened. Seasonal schooling migration may con- tribute to the genetically homogeneous population structure of the species. | GAO Tianxiang LI Lin FANG Rundong LIU Guanghui WANG Lei XU Hanxiang SONG Na | 2019 | Journal of Ocean University of China2019，18，4： | 2 |
| 18 | Graphitic carbon nitride-based photocatalysts in the applications of environmental catalysis显示文摘Semiconductor photocatalytic technology has shown great prospects in converting solar energy into chemical energy to mitigate energy crisis and solve environmental pollution problems.The key issue is the development of high-efficiency photocatalysts.Various strategies in the state-of-the-art advancements,such as heterostructure construction,heteroatom doping,metal/single atom loading,and defect engineering,have been presented for the graphitic carbon nitride(g-C3N4)-based nanocomposite catalysts to design their surface chemical environments and internal electronic structures to make them more suitable for different photocatalytic applications.In this review,nanoarchitecture design,synthesis methods,photochemical properties,potential photocatalytic applications,and related reaction mechanisms of the modified high-efficiency carbon nitride-based photocatalysts were briefly summarized.The superior photocatalytic performance was identified to be associated with the enhanced visible-light response,fast photoinduced electron-hole separation,efficient charge migration,and increased unsaturated active sites.Moreover,the further advance of the visible-light harvesting and solar-to-energy conversions are proposed. | Hongxia Lin JinmoWu Fan Zhou Xiaolong Zhao Pengfei Lu Guanghui Sun Yuhan Song Yayun Li Xiaoyong Liu Hongxing Dai | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 19 | Polyhexamethylene biguanide chemically modified cotton with desirable hemostatic,inflammation-reducing,intrinsic antibacterial property for infected wound healing显示文摘Medical cotton dressing is cheap and widely used in diversified fields,but in the application of promoting wound healing,the continuous research of multifunctional medical cotton dressing is still of great significance.Here,we developed a fresh type of antibacterial cotton dressing through a succinct strategy based on chemically anchoring polyhexamethylene biguanide(PHMB).Intriguingly,after PHMB modification,the cotton dressing exhibited outstanding antibacterial performance which could maintain>99.99%antibacterial rate after several treatments,including washing 50 times,repeated use 10 times,UV irradiation for 7 days,cationic dyes dying,and conditioned under 90℃water bath for 2 h.In addition,the water contact angle of cotton dressing increased dramatically from 0°to 111°,which could facilitate bacterial adhesion,thus further enhance the antibacterial efficiency,and easily remove the bacterial debris.Apart from that,the developed cotton dressing showed good cytocompatibility,promoted blood clotting and expression of platelets,and promoted the wound healing process in the infection intervened skin wound model.Taken together,this antibacterial cotton dressing with desirable blood clotting,sustained protection against bacterial infection and bacterial removal features shows the potential to be a candidate for infected skin wound healing. | Chuan Guo Jie Zhang Xiaojun Feng Zhenggui Du Yuanzhang Jiang Yidong Shi Guanghui Yang Lin Tan | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 20 | Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARαto restore spermatogenesis in cryptorchid infertile rats显示文摘Cryptorchidism-caused adult infertility is a common component of idiopathic reasons for male infertility.Retinoic acid(RA)has a vital effect on the spermatogenesis process.Here,we found that the expression of c-Kit,Stra8,and Sycp3 could be up-regulated via the activation of retinoic acid receptorα(RARα)after RA supplementation in neonatal cryptorchid infertile rats.We also demonstrated that the protein expression of PI3K,p-Akt/pan-Akt,and p-mTOR/mTOR was higher in cryptorchid than in normal testes,and could be suppressed with RA in vivo.After RA treatment in infertile cryptorchid testis in vivo,the levels of the autophagy proteins LC3 and Beclin1 increased and those of P62 decreased.Biotin tracer indicated that the permeability of blood-testis barrier(BTB)in cryptorchid rats decreased after RA administration.Additionally,after blocking the RARαwith AR7(an RARαantagonist)in testicle culture in vitro,we observed that compared with normal testes,the PI3K-Akt-mTOR signaling pathway and the autophagy pathway was increased and decreased,respectively,which were coincident with cryptorchisd testes in vivo.Additionally,the appropriate concentrations of RA treatment could depress the PI3K-Akt-mTOR signaling pathway and improve the autophagy pathway.The results confirmed that RA can rehabilitate BTB function and drive key protein levels in spermatogonial differentiation through depressing the PI3K-Akt-mTOR signaling pathway via RARα. | Chunlan Long Yu Zhou Lianju Shen Yihang Yu Dong Hu Xing Liu Tao Lin Dawei He Tao Xu Deying Zhang Jing Zhu Guanghui Wei | 2022 | Genes & Diseases2022，9，5： | 2 |
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