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| 1 | Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study显示文摘AIM To analyze liver tests before and following treatment with herbal Traditional Chinese Medicine(TCM) in order to evaluate the frequency of newly detected liver injury.METHODS Patients with normal values of alanine aminotransferase(ALT) as a diagnostic marker for ruling out pre-existing liver disease were enrolled in a prospective study of a safety program carried out at the First German Hospital of TCM from 1994 to 2015. All patients received herbal products, and their ALT values were reassessed 1-3 d prior to discharge. To verify or exclude causality for suspected TCM herbs, the Roussel Uclaf Causality Assessment Method(RUCAM) was used.RESULTS This report presents for the first time liver injury data derived from a prospective, hospital-based and largescale study of 21470 patients who had no liver disease prior to treatment with herbal TCM. Among these, ALT ranged from 1 × to < 5 × upper limit normal(ULN) in 844 patients(3.93%) and suggested mild or moderate liver adaptive abnormalities. However, 26 patients(0.12%) experienced higher ALT values of ≥ 5 × ULN(300.0 ± 172.9 U/L, mean ± SD). Causality for TCM herbs was RUCAM-based probable in 8/26 patients, possible in 16/26, and excluded in 2/26 cases. Bupleuri radix and Scutellariae radix were the two TCM herbs most commonly implicated. CONCLUSION In 26(0.12%) of 21470 patients treated with herbal TCM, liver injury with ALT values of ≥ 5 × ULN was found, which normalized shortly following treatment cessation, also substantiating causality. | Dieter Melchart Stefan Hager Sabine Albrecht Jingzhang Dai Wolfgang Weidenhammer Rolf Teschke | 2017 | World Journal of Hepatology2017，9，29： | 11 |
| 2 | 作为添加剂的颗粒状有机硅树脂在热塑性塑料中的应用显示文摘描述了一种以超高分子量(uhmw)的聚二甲基硅氧烷(PDMS)为基料的新型、多功能固体有机硅添加剂,着重描述了这些新型颗粒状有机硅树脂作为添加剂应用于热塑性塑料挤出。通过实例说明了颗粒状有机硅树脂能非常有效地改善热塑性塑料的加工性和流动性,尤其适用于充填的聚烯烃混合物。此外,它们能进一步提高冲击强度和抗张强度等机械性能,并且对于改善表面光滑性和抗磨损性也十分有效。 | Rudolf Hager Michael Geck Oliver Fuhrmann | 2004 | 塑料助剂2004，，6： | 3 |
| 3 | Recent advances in polymer composites tribology显示文摘 | Friedrich K Lu Z Hager A M | 1995 | Wear1995，190，： | 2 |
| 4 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 5 | A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation显示文摘 | Stacey J. Wieczorek Alan H.B. Wu Robert Christenson Padma Krishnaswamy Stephen Gottlieb Thomas Rosano David Hager Nancy Gardetto Albert Chiu Kathryn R. Ba illy Alan Maisel | 2002 | American Heart Journal2002，，5： | 2 |
| 6 | The geometric mean decomposition显示文摘 | Jiang Y Hager W Li J | 2005 | Linear Algebra and Its Applications2005，396，： | 1 |
| 7 | Classifying facial actions显示文摘 | Donato G Bartlett M S Hager J C | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，10： | 1 |
| 8 | A survey of nonlinear conjugate gradient methods, Pacific Journal of Optimization显示文摘 | Hager W W Zhang H C | 2006 | (2) : 35-582006，，2： | 1 |
| 9 | Alpha-synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356 显示文摘 | Jensen PH Hager H Nielsen MS | 1999 | J Biol Chem1999，274，25： | 1 |
| 10 | Runge-Kutta methods in optimal control and thetransformed adjoint system显示文摘 | Hager W | 2000 | Numerische Mathematik2000，87，2： | 1 |
| 11 | Performance analysis and optimization strategies for a D3Q19 lat tice Boltzmann kernel on nVIDIA GPUs using CUDA 显示文摘 | Habich J Zeiser T Hager G | 2011 | Advances in Engineering Software2011，42，5： | 1 |
| 12 | An optically pumped mid-infrared HBr laser显示文摘 | Miller H C Radzykewycz Jr D T Hager G | 1994 | IEEE Journal of Quantum Electronics1994，30，10： | 1 |
| 13 | Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase- deficient mouse model of human hyper-IgD syndrome (HIDS) 显示文摘 | Hager EJ Piganelli JD Tse HM | 2012 | J Inherit Metab Dis2012，35，1： | 1 |
| 14 | A nonmonotone line search technique and its application to unconstrained optimization 显示文摘 | ZHANG Hongchao Hager William W | 2004 | SIAM J Optim2004，14，4： | 1 |
| 15 | In vitro iontophoretic delivery of CQA 206-291: influence of ethanol显示文摘 | Hager DF Laubach MJ Sharkey JW | 1993 | J Cont rolled Release1993，23，： | 1 |
| 16 | Measurement of crustal deformation using the Global Positioning System 显示文摘 | Hager B H King R E and Murra M H | 1991 | Annu Rev Earth Sci1991，19，： | 1 |
| 17 | Coal liquefaction and catalysis显示文摘 | DerbyshireF Hager T | 1994 | Fuel1994，73，7： | 1 |
| 18 | Asymmetric epoxidation of functionalized cis-olefins catalyzed by chloroperoxidase 显示文摘 | Hu S Hager L P | 1999 | Tetrahedron Lett1999，0，9： | 1 |
| 19 | An hp-adaptive pseudospectral method for solving optimal control problems 显示文摘 | Darby C L Hager W W Rao A V | 2011 | Optimal Control Applications and Methods2011，32，4： | 1 |
| 20 | Stepped chutes:pre-aeration and spray reduction显示文摘 | PFISTER M HAGER W H MINOR H E | 2006 | International Journalof Multiphase Flow2006，32，2： | 1 |
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