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| 1 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 2 | 慢性丙型肝炎患者糖代谢异常及其相关因素研究显示文摘目的丙型肝炎病毒(hepatitis C virus,HCV)患者常常伴随胰岛素抵抗以及糖尿病发生。本研究旨在探究慢性丙型肝炎(chronic hepatitis C,CHC)患者发生血糖异常的相关因素。方法本研究共纳入1 039名未经治疗的CHC患者。研究对象人口学资料、生化检查指标及其肝脏功能和HCV病毒载量等资料均来源于句容市人民医院传染科。结果有140名(13.5%)CHC患者被诊断为糖代谢异常。身体质量指数(x^2=9.231,P=0.010)、腰围(x^2=7.984,P=0.018)、收缩压(x^2=16.366,P<0.001)、舒张压(x^2=13.970,P=0.001)、丙氨酸转氨酶(alanine aminotransferase,ALT)(x^2=4.809,P=0.028)以及HCV-RNA载量(t=-3.818,P<0.001)等在CHC患者糖代谢正常与异常组间的分布差异具有统计学意义。多元回归分析发现,ALT(OR=2.986,95%CI:1.171~7.615)、HCV-RNA载量(OR=2.061,95%CI:1.165~3.644)为CHC患者合并糖代谢异常的危险因素。结论 ALT、HCVRNA载量可作为CHC患者糖代谢异常的提示因子,仍需对更多临床资料以及相关基因作进一步研究以发现CHC患者发生糖代谢异常新的危险因素。 | 刘梅 臧凤 姚轶男 黄鹏 喻荣彬 | 2017 | 中华疾病控制杂志2017，21，9： | 3 |
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