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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Multiaxial fatigue damage criterion显示文摘 | ELLYIN F GOLOS K | 1988 | J Eng Mater Technol ASME1988，110，1： | 1 |
| 3 | Synergistic effects of vascular en- dothelial growth factor and basic fibroblast growth factor on Ihe pro- liferation and cord Jbrmation of bovine capillary endothelial cells within collagen gels 显示文摘 | Golo F Gnto K Weindel K | 1993 | Lab Invest1993，69，5： | 1 |
| 4 | A total strain energy density theory for cumulative fatigue damage显示文摘 | Golos K Ellyin F | 1988 | J Pressure Vessel Technology ASME1988，110，： | 1 |
| 5 | A total strain energy density theory for cumulative fatigue damage显示文摘 | Golos'K Ellyin F | 1988 | J Pressure Vessel Technology ASME1988，110，： | 1 |
| 6 | Total strain-energy density theory for cumulative fatigue damage 显示文摘 | GOLOS K ELLYIN F | 1988 | ASME J Press Vess Teeh1988，110，1： | 1 |
| 7 | Prediction of crack growth direc- tion under plane stress for mixed-mode I and II load- ing显示文摘 | Wasiluk B Golos K | 2000 | Fatigue & Fracture of Engineering Materials Structures2000，23，5： | 1 |
| 8 | A transient current based double line transmission system protection using fuzzywavelet approach in the presence of UPFC显示文摘 | GOLO R K SHAIK A G RAM S S T | 2015 | International Journal of Electrical Power&Energy Systems2015，70，： | 1 |
| 9 | Muhiaxial Fatigure Damage Criterion显示文摘 | Ellyin F Golos K | 1988 | Journal of Engineering Materials and Technology Transactions of the ASME1988，110，11： | 1 |
| 10 | Multiaxial Fatigue Damage Criterion显示文摘 | Ellyin F Golos K | 1988 | J Engng Mater Tech1988，110，： | 1 |
| 11 | Immunoactivalive role of indoleamine 2,3 -dioxygenase in human hepalocellular carcinoma显示文摘 | Ishio T Golo S Tahara K | 2004 | J Gaslroenterol Hepatol2004，19，： | 1 |
| 12 | Association of serum uric acid with blood pressure in Japanese men显示文摘 | Kansui Y Ohtsubo T Golo K | 2011 | Circ J2011，75，12： | 1 |
| 13 | A total strain-energy density theory for cumulative fatigue damage显示文摘 | Golos K Ellyin F | 1988 | ASME Journal of Pressure Vessel Technology1988，110，1： | 1 |
| 14 | Atotal strain energy density model of metal fatigue显示文摘 | Golos K M | | 0，，1： | 1 |
| 15 | Generalization of cumulative damage criterion to multilevel cyclicloading显示文摘 | Golos K Elyin F | | 0，，03： | 1 |
| 16 | Total strain energy density theory for cumulative fatigue damage 显示文摘 | GOLOS K ELLYIN F | 1988 | ASME J Press Vess Tech1988，110，1： | 1 |
| 17 | A total strain energy density theory forcumulative fatigue damage显示文摘 | Golos K Ellyin F | 1988 | Journal of Pressure VesselTechnology1988，110，1： | 1 |
| 18 | Hepatilis C virus induced hepatocellu-lar carcinoma associated genes 显示文摘 | Kato N Muroyama R Golo K | 2015 | Nihon Rinsho2015，73，2： | 1 |
| 19 | Total strain-energy density theory for cumulative fatigue damage 显示文摘 | GOLOS K ELLYIN F | 1988 | ASME J Press Vess Tech1988，110，1： | 1 |
| 20 | Role of plastic zone in crack growth direction criterion under mixed mode loading显示文摘 | Golos K Wasiluk B | 2000 | International Journal of Fracture2000，102，： | 1 |
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