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| 1 | Fetal programming and early identification of newborns at high risk of free radical-mediated diseases显示文摘Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. Pregnancy complications such as diabetes, intrauterine growth restriction, preeclampsia, and hypoxia are associated with placental dysfunction and programming. Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. In recent years, elucidating the mechanisms involved in such kind of process has become the challenge of scientific research. Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. Maternal diabetes, prenatal hypoxic/ischaemic events, inflammatory/infective insults are specific triggers for an acute increase in free radicals generation. Early identification of fetuses and newborns at high risk of oxidative damage may be crucial to decrease infant and adult morbidity. | Serafina Perrone Antonino Santacroce Anna Picardi Giuseppe Buonocore | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 4 |
| 2 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 4 | Non-cirrhotic portal hypertension with large regenerative nodules: A diagnostic challenge显示文摘Non-cirrhotic portal hypertension is a poorly understood condition characterized by portal hypertension in the absence of conventional hepatic cirrhosis and described in association with blood coagulation disorders, myeloproliferative and immunological diseases and with exposure to toxic drugs. Very recently, precise classification criteria have been proposed in order to define four distinct subcategories. The present case highlights how the clinical presentation, the confounding results from imaging studies, and the difficulties in the histological evaluation often render cases of non-cirrhotic portal hypertension a real diagnostic challenge. It also underscores the classification problems which can be faced once this diagnosis is performed. Indeed, the different subcategories proposed result from the prevalent subtypes in a spectrum of hepatic regenerative responses to a variety of injuries determining microcirculatory dis-turbances. More flexibility in classification should derive from this etiopathogenic background. | Umberto Vespasiani Gentilucci Paolo Gallo Giuseppe Perrone Riccardo Del Vescovo Giovanni Galati Sandro Spataro Chiara Mazzarelli Adriano Pellicelli Antonella Afeltra Antonio Picardi | 2011 | World Journal of Gastroenterology2011，17，20： | 2 |
| 5 | Association Between a Polymorphism in Cannabinoid Receptor 2 and Severe Necroinflammation in Patients With Chronic Hepatitis C显示文摘 | Nicola Coppola Rosa Zampino Giulia Bellini Margherita Macera Aldo Marrone Mariantonietta Pisaturo Adriana Boemio Bruno Nobili Giuseppe Pasquale Sabatino Maione Luigi Elio Adinolfi Laura Perrone Evangelista Sagnelli Emanuele Miraglia Del Giudice Francesca | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 6 | Portal inflammation during NAFLD is frequent and associated with the early phases of putative hepatic progenitor cell activation显示文摘 | Carotti Simone Vespasiani-Gentilucci Umberto Perrone Giuseppe Picardi Antonio Morini Sergio | 2015 | Journal of Clinical Pathology2015，，11： | 1 |
| 7 | Hepatic toll‐like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD显示文摘 | Umberto Vespasiani‐Gentilucci Simone Carotti Giuseppe Perrone Chiara Mazzarelli Giovanni Galati Andrea Onetti‐Muda Antonio Picardi Sergio Morini | 2015 | Liver Int2015，，2： | 1 |
| 8 | Accuracy of three-dimensional ultrasound in diagnosis and classification of congenital uterine anomalies显示文摘 | Tullio Ghi Paolo Casadio Marina Kuleva Anna Myriam Perrone Luca Savelli Susanna Giunchi Maria Cristina Meriggiola Giampietro Gubbini Gianluigi Pilu Carla Pelusi Giuseppe Pelusi | 2009 | Fertility and Sterility2009，，2： | 1 |
| 9 | HER2 amplification status in gastric and gastro‐oesophageal junction cancer in routine clinical practice: which sample should be used?显示文摘 | Giuseppe Perrone Michelina Amato Marcella Callea Carla Rabitti Daniela Righi Pierfilippo Crucitti Roberto Coppola Andrea Onetti Muda | 2012 | Histopathology2012，，1： | 1 |
| 10 | Molecular aspects of the cardioprotective effect of exercise in the elderly显示文摘 | Giuseppe Rengo Valentina Parisi Grazia Daniela Femminella Gennaro Pagano Claudio de Lucia Alessandro Cannavo Daniela Liccardo Francesco Giallauria Oriana Scala Carmela Zincarelli Pasquale Perrone Filardi Nicola Ferrara Dario Leosco | 2013 | Aging Clinical and Experimental Research2013，，5： | 1 |
| 11 | Diagnostic accuracy of 18F-FDG PET/CT in characterizing ovarian lesions and staging ovarian cancer: Correlation with transvaginal ultrasonography, computed tomography, and histology显示文摘 | Paolo Castellucci Anna M. Perrone Maria Picchio Tullio Ghi Mohsen Farsad Cristina Nanni Cristina Messa Maria C. Meriggiola Giuseppe Pelusi Adil Al-Nahhas Domenico Rubello Ferruccio Fazio Stefano Fanti | 2007 | Nuclear Medicine Communications2007，，： | 1 |
| 12 | Numerical Studies on the Seismic Retrofit of Bridges Using Shape Memory Alloys 显示文摘 | Donatello Cardone Giuseppe Perrone Salvatore Sofia | 2010 | Materials Engineering and Performance2010，20，： | 1 |
| 13 | Takotsubo Cardiomyopathy: Overview显示文摘 | Eduardo Bossone Gianluigi Savarese Francesco Ferrara Rodolfo Citro Susanna Mosca Francesca Musella Giuseppe Limongelli Roberto Manfredini Antonio Cittadini Pasquale Perrone Filardi | 2012 | Heart Failure Clinics2012，，： | 1 |
| 14 | Association Between a Polymorphism in Cannabinoid Receptor 2 and Severe Necroinflammation in Patients With Chronic Hepatitis C显示文摘 | Nicola Coppola Rosa Zampino Giulia Bellini Margherita Macera Aldo Marrone Mariantonietta Pisaturo Adriana Boemio Bruno Nobili Giuseppe Pasquale Sabatino Maione Luigi Elio Adinolfi Laura Perrone Evangelista Sagnelli Emanuele Miraglia Del Giudice Francesca | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | Tachosisealed tubeless percutaneous nephrolithotomy to reduce urine leakage and bleeding: outcome of a randomized controlled study 显示文摘 | Luigi Cormio Antonia Perrone Giuseppe Di Fino | 2012 | J Urol2012，188，1： | 1 |
| 16 | Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer显示文摘 | Giuseppe Perrone Pier Adelchi Ruffini Vincenzo Catalano Cathie Spino Daniele Santini Pietro Muretto Chiara Spoto Costantino Zingaretti Valerio Sisti Paolo Alessandroni Paolo Giordani Andrea Cicetti Silvia D’Emidio Sergio Morini Annamaria Ruzzo Mauro Magna | 2008 | European Journal of Cancer2008，，13： | 1 |
| 17 | Non protein bound iron as early predictive marker of neonatal brain damage 显示文摘 | Giuseppe Buonocore Serafina Perrone | 2003 | Brain2003，126，5： | 1 |
| 18 | Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene显示文摘 | Giuseppe Pelosi Patrizia Gasparini Alberto Cavazza Giulio Rossi Paolo Graziano Mattia Barbareschi Federica Perrone Massimo Barberis Masayuki Takagi Toshiaki Kunimura Tetsuya Yamada Yukio Nakatani Ugo Pastorino Paolo Scanagatta Gabriella Sozzi Marina Garas | 2012 | Lung Cancer2012，，3： | 1 |
| 19 | Accuracy of three-dimensional ultrasound in diagnosis and classification of congenital uterine anomalies显示文摘 | Tullio Ghi Paolo Casadio Marina Kuleva Anna Myriam Perrone Luca Savelli Susanna Giunchi Maria Cristina Meriggiola Giampietro Gubbini Gianluigi Pilu Carla Pelusi Giuseppe Pelusi | 2009 | Fertility and Sterility2009，，： | 1 |
| 20 | Early identification of the risk for free radical-related diseases in preterm newborns显示文摘 | Serafina Perrone Maria Luisa Tataranno Simona Negro Mariangela Longini Barbara Marzocchi Fabrizio Proietti Francesca Iacoponi Serena Capitani Giuseppe Buonocore | 2010 | Early Human Development2010，，4： | 1 |
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