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| 1 | Hepatitis C virus and type 2 diabetes显示文摘This review focuses on the relationship between hepatitis C virus(HCV) infection and glucose metabolism derangements.Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance(IR) and type 2 diabetes(T2D).The direct effect of HCV on the insulin signaling has been analyzed in experimental models.Although currently available data should be considered as preliminary,HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response.IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C,but also reduce the early and sustained virological response to interferon-alpha-based therapy.Thus,a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted,in order to improve the clinical management of chronic hepatitis C patients. | Francesco Negro Mahnaz Alaei | 2009 | World Journal of Gastroenterology2009，15，13： | 14 |
| 2 | Mechanisms and significance of liver steatosis in hepatitis C virus infection显示文摘The pathogenesis of liver damage associated with chronic hepatitis C virus (hCV) infection is thought to be largely immunomediated. however, some frequent histo- pathological features, such as steatosis, suggest a direct cytopathic effect of hCV. The direct responsibility of hCV in the pathogenesis of steatosis is shown by: (1) the as- sociation with hCV genotype 3 infection, suggesting that some viral sequences are involved in the intracellular ac- cumulation of lipids; (2) the correlation between severity of steatosis and hCV replication levels; (3) association between response to treatment and disappearance of steatosis. Experimental studies have shown that the nu- cleocapsid protein of hCV (core protein) is capable and sufficient to induce lipid accumulation in hepatocytes. Moreover, the observation that chronic hepatitis C pa- tients have reduced serum levels of ApoB suggests an interference with the very-low density lipoprotein (VLDL) assembly, although other mechanisms are possible. in patients with sustained virological response induced by antiviral therapy, such levels are normalized. Other ob- servations suggest that the pathogenesis of steatosis in chronic hepatitis C is not solely due to hCV. The origin of the mild steatosis observed in most patients may be metabolic, since its severity correlates with body mass index and insulin resistance. Most studies have shown a correlation between presence and/or severity of steatosis and fibrosis stage, but it is unclear whether this effect is direct or mediated by the associated insulin resistance, increased susceptibility to apoptosis, or by inflamma- tory cytokines. Finally, steatosis negatively influences the rate of response to antiviral treatment, as confirmed by large clinical trials. Management of steatosis in chronic hepatitis C requires knowledge of its pathogenesis and may involve both life-style changes and pharmacological interventions, although the latter remain largely experi- mental. | francesco Negro | 2006 | World Journal of Gastroenterology2006，12，42： | 13 |
| 3 | Correction of low corneal astigmatism in cataract surgery显示文摘· AIM: To evaluate and compare aspheric toric intraocular lens(IOL) implantation and aspheric monofocal IOL implantation with limbal relaxing incisions(LRI) to manage low corneal astigmatism(1.0-2.0 D) in cataract surgery.· METHODS: A prospective randomized comparative clinical study was performed. There were randomly recruited 102 eyes(102 patients) with cataracts associated with corneal astigmatism and divided into two groups. The first group received toric IOL implantation and the second one monofocal IOL implantation with peripheral corneal relaxing incisions. Outcomes considered were: visual acuity, postoperative residual astigmatism, endothelial cell count, the need for spectacles, and patient satisfaction. To determine the postoperative toric axis, all patients who underwent the toric IOL implantation were further evaluated using an OPD Scan III(Nidek Co, Japan). Follow-up lasted 6mo.· RESULTS: The mean uncorrected distance visual acuity(UCVA) and the best corrected visual acuity(BCVA) demonstrated statistically significant improvement after surgery in both groups. At the end of the follow-up the UCVA was statistically better in the patients with toric IOL implants compared to those patients who underwent implantation of monofocal IOL plus LRI. The mean residual refractive astigmatism was of 0.4 D for the toric IOL group and 1.1 D for the LRI group(P <0.01). No difference was observed in the postoperative endothelial cell count between the two groups.· CONCLUSION: The two surgical procedures demonstrated a significant decrease in refractive astigmatism. Toric IOL implantation was more effective and predictable compared to the limbal relaxing incision. | Pia Leon Marco Rocco Pastore Andrea Zanei Ingrid Umari Meriem Messai Corrado Negro Daniele Tognetto | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 8 |
| 4 | Real-time multiplex PCR assay to quantify hepatitis C virus RNA in peripheral blood mononuclear cells显示文摘 | Paolo Pugnale Patrizia Latorre Christine Rossi Katia Crovatto Valerio Pazienza Andrea De Gottardi Francesco Negro | 2005 | Journal of Virological Methods2005，，2： | 3 |
| 5 | phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease显示文摘AIM: To investigate the protein expression of phosphatase and tensin homolog(PTEN) in human liver biopsies of patients with alcoholic and non-alcoholic liver disease.METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffinembedded liver sections of patients with non-alcoholic fatty liver disease(NAFLD)(n = 44) or alcoholic liver disease(ALD)(n = 25). Liver resections obtained from 3 healthy subjects candidate for partial liver donation served as controls. Histological evaluations were performed by two experienced pathologists, and diagnoses established based on international criteria. The intensity of the PTEN staining in nuclei was compared between steatotic and non-steatotic areas of each liver fragment analyzed. For each liver specimen, the antibody-stained sections were examined and scored blindly by three independent observers, who were unaware of the patients' clinical history.RESULTS: In healthy individuals, PTEN immunostaining was intense in both the cytoplasm and nuclei of all hepatocytes. However, PTEN was strongly downregulated in both the nucleus and the cytoplasm of hepatocytes from steatotic areas in patients with NAFLD, independently of the disease stage. In contrast, no changes in PTEN protein expression were observed in patients with ALD, regardless of the presence of steatosis or the stage of the disease. The degree of PTEN downregulation in hepatocytes of patients with NAFLD correlated with the percentage of steatosis(r = 0.3061, P = 0.0459) and the BMI(r = 0.4268, P = 0.0043). Hovewer, in patients with ALD, PTEN expression was not correlated with the percentage of steatosis with or without obesity as a confounding factor(P = 0.5574). Finally, PTEN expression level in steatotic areas of ALD patients was significantly different from that seen in steatotic areas of NAFLD patients(P < 0.0001).CONCLUSION: PTEN protein expression is downregulated early in NAFLD, but not in ALD. PTEN immunohistochemical detection could help in the differential diagnosis of NAFLD and ALD. | Andrea Sanchez-Pareja Sophie Clément Marion Peyrou Laurent Spahr Francesco Negro Laura Rubbia-Brandt Michelangelo Foti | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 6 | Epidemiology of hepatitis C in Europe显示文摘 | Francesco Negro | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 7 | Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C显示文摘 | Christine Bernsmeier Francois H.T. Duong Verena Christen Paolo Pugnale Francesco Negro Luigi Terracciano Markus H. Heim | 2008 | Journal of Hepatology2008，，3： | 2 |
| 8 | The interaction of metabolic factors with HCV infection: Does it matter?显示文摘 | Elisabetta Bugianesi Federico Salamone Francesco Negro | 2012 | Journal of Hepatology2012，，： | 2 |
| 9 | Implantation of AMS 700 LGX penile prosthesis preserves penile length without the need for penile lengthening procedures显示文摘当保守处理失败时,可膨胀的阴茎修复术(IPP ) 的培植是可勃起的机能障碍的一个生长得很好的权威的解决方案。阴茎植入可以弄短阴茎。AMS 700 LGX IPP 在普通使用,但是在它的机械可靠性,中期的 postsurgical 病人满足,和吝啬的阴茎长度上报导保藏正在缺乏。我们在 AMS 700 LGX 的培植以后在 6 和 12 个月调查吝啬的阴茎长度,机械可靠性,和耐心的满足。这未来的研究连续地注册了经历初次的 IPP 的人从 2009 年 2 月植入外科到 2012 年 4 月。拉长的松驰的阴茎长度,在 50% 点的阴茎长度和僵硬(P50 和 P100 ) 和可勃起的功能(IIEF ) 和可勃起的机能障碍的国际索引的 100% 治疗盘点满足(编辑) 分数,在 6 和 12 月 postsurgery 被测量。经历了 AMS 700 LGX 培植的 45 个病人(中部的年龄 61 年) 并且完成了 6 月的后续,(80%) 36 完成了学习。在拉长的松驰的阴茎长度的重要差别在 6 和 12 个月之间被看见(P = 0.033 ) 。P100 显著地也在 6 和 12 个月被增加,与到 12 个月的从基线的 10% 增加的一个平均数(1.3 0.4 厘米) 。在在 6 和 12 个月的吝啬的 IIEF 分数的差别为需要的领域是重要的(P = 0.0001 ) 并且为全面满足(P = 0.002 ) ;然而,平均数在 6 和 12 个月编辑分数显著地没被改进。AMS 700 LGX 是为在经历阴茎修复术培植的人保存阴茎长度的一个强大的工具。 | Carlo Luigi Augusto Negro Matteo Paradiso Alessandro Rocca Franco Bardari | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 10 | The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8显示文摘 | Sophie Clément Stéphanie Pascarella Stéphanie Conzelmann Carmen Gonelle-Gispert Kévin Guilloux Francesco Negro | 2010 | Journal of Hepatology2010，，5： | 2 |
| 11 | Influence of manual preflaring and torque on the failure rate of ProTaper rotary instruments显示文摘 | Berutti E Negro AR Lendini M | 2004 | J Endod2004，30，： | 1 |
| 12 | Pioglitazone reduces blood pressure in non-dipping diabetic patients显示文摘 | Negro R Dazzi D Hassan H | 2004 | Minerva Endocrinol2004，29，1： | 1 |
| 13 | Ciliary neurotrophic factor (CNTF) signals through STAT3 SOCS3 pathway and protects rat pancreatic islets from cytokine induced apoptosis 显示文摘 | Rezende L F Vieira A S Negro A | 2009 | Cytokine2009，46，1： | 1 |
| 14 | Arterial hypertension in the adolescent:its possible relation to the salt taste threshold 显示文摘 | del Negro MC Oliver M Arocha I | 1992 | Rev Esp Cardiol1992，45，4： | 1 |
| 15 | Phytoplankton structure and dynamics in Lake Sanabria and Valparaiso reservoir (NW Spain)显示文摘 | Negro A I Hoyos C D Vega J | 2000 | Hydrobiologia2000，424，： | 1 |
| 16 | Hepatitis C virus, steatosis and lipid abnor- malities: clinical and pathogenic data显示文摘 | Negro F Sanyal AJ | 2009 | Liver Int2009，29，12： | 1 |
| 17 | A meta-analysis of randomized controlled trials in pulmonary arterial hypertension显示文摘 | Galie N Manes A Negro L | 2009 | Eur HeartJ2009，30，4： | 1 |
| 18 | Evaluation of the photocatalytic inactivation efficiency of dairy bacteriophages显示文摘 | Marcó MB Quiberoni A Negro AC | 2011 | Chem Eng J2011，172，23： | 1 |
| 19 | Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease:effects on obstetrical complications显示文摘 | Negro R Formoso G Mangieri T | | 0，，07： | 1 |
| 20 | Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease:effects on obstetrical complications显示文摘 | NEGRO R FORMOSO G MANGIERI T | 2006 | The Journal of Clinical Endocrinology and Metabolism2006，91，7： | 1 |
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