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| 1 | Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease?显示文摘The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines,resulting in the upregulation of the iron hormone hepcidin,also increased by iron therapy and reduced glomerular filtration,with consequent reduction in iron absorption,recycling,and availability to the erythron.This response proves advantageous in the short-term to restrain iron availability to pathogens,but ultimately leads to severe anemia,and impairs the response to erythropoietin(Epo)and iron.Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores,thereby resulting in inadequate inhibition of the activity of Ferroportin-1,inappropriately high iron absorption and recycling,and iron overload.However,in hemodialysis patients,carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation,thereby improving iron availability to erythropoiesis,anemia control,the response to Epo,and possibly survival.Therefore,anti-hepcidin therapies may improve anemia management in hemodialysis.However,HFE mutations directly favor hemoglobinization independently of hepcidin,and reduce macrophages activation in response to inflammation,whereas hepcidin might also play a beneficial anti-inflammatory and anti-microbic action during sepsis,so that direct inhibition of HFEmediated regulation of iron metabolism may represent a valuable alternative therapeutic target.Genetic studies may offer a valuable tool to test these hypotheses and guide the research of new therapies. | Elena Canavesi Carlo Alfieri Serena Pelusi Luca Valenti | 2012 | World Journal of Nephrology2012，1，6： | 5 |
| 2 | Effect of flutamide and mefformin administerer alone or in combination dieting obese women with polycystic ovary ayndrone 显示文摘 | GambineriA Pelusi C Genghini S | 2004 | Clin Endocrinol2004，60，2： | 1 |
| 3 | Effdct of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome显示文摘 | Pelusi C Genghini S | 2004 | Clin Endocrinol(0xf)2004，60，2： | 1 |
| 4 | Obesity and the polycystic ovary syndrome显示文摘 | Gambineri A Pelusi C Vicennati V | 2002 | Int J Obes Relat Metab Disord2002，26，7： | 1 |
| 5 | Opportunistic networking: data forwarding in disconnected mobile Ad hoc networks 显示文摘 | PELUSI L PASSARELLA A CONTI M | 2006 | Communications Magazine2006，44，11： | 1 |
| 6 | Opportunistic networking: data forwarding in disconnected mobile Ad hoc networks 显示文摘 | PELUSI L PASSARELLA A CONTI M | 2006 | Com- munications Magazine2006，44，11： | 1 |
| 7 | Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to ox-ygen desaturation, body weight, fat distribution and the metabolic parameters显示文摘 | Gambineri A Pelusi C Pasquali R | 2003 | Journal of endocrinological investigation2003，26，6： | 1 |
| 8 | Opportunistic networking:data forwarding in disconnected mobile ad hoc networks显示文摘 | Pelusi L Passarella A Conti M | | 0，，11： | 1 |
| 9 | Opportunistic networking:data forwarding in disconnected mobile ad hoc networks显示文摘 | Pelusi L Passarella A Conti M | 2006 | Communications Magazine IEEE2006，44，11： | 1 |
| 10 | Opportunistic networking: data forwarding in disconnected mobile Ad Hoc networks显示文摘 | PELUSI L PASSARLLA A CONTI M | 2006 | IEEE Communication Magazine2006，44，11： | 1 |
| 11 | Terminally ill cancer pa- tients' wish to hasten death 显示文摘 | Kelly B Burnett P Pelusi D | 2002 | Palliative Medicine2002，16，4： | 1 |
| 12 | Obesity and the polycystic ovary syndrome显示文摘 | Gambineri A Pelusi C Vicennati V | 2002 | Int J Obes Relat Metab Disord2002，26，7： | 1 |
| 13 | Obesity and reproductive disorders in women显示文摘 | Pasquali R Pelusi C Genghini S | 2003 | Hum Reprod Update2003，4，： | 1 |
| 14 | Obesity and the poly- cystic ovary syndrome 显示文摘 | Gambineri A Pelusi C Vicennati V | 2002 | Int J Obes Relat Metab Disord2002，26，7： | 1 |
| 15 | Obesityand reproductive disorders in women显示文摘 | Pasquali R Pelusi C Genghini S | 2003 | Hum Reprod Update2003，9，4： | 1 |
| 16 | Obesity and the polycys- tic ovary syndrome显示文摘 | Gambineri A Pelusi C Vicennati V | 2002 | Int J Obes Relat Metab Dis2002，26，7： | 1 |
| 17 | Generation of 20 fs optical pulse from a gain-switched laser diode by a four-stage soliton compression technique显示文摘 | MATSUI Y PELUSI M D SUZUKI A | 1999 | IEEE Photonics Technology Letters1999，11，10： | 1 |
| 18 | Terminally ill cancer patients wish to hasten death显示文摘 | Kelly B Bumett P Pelusi D | 2002 | Palliative Med2002，16，4： | 1 |
| 19 | Opportunistic networking:data forwarding in disconnected mobile Ad Hoc networks显示文摘 | PELUSI L PASSARELLA A CONTI M | | 0，，11： | 1 |
| 20 | High bit rate all- optical signal processing in a fiber photonic wire显示文摘 | PELUSI M D LUAN F MAGI E | 2008 | Optics Express2008，16，11： | 1 |
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