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| 1 | H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease显示文摘AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P < 0.001) and CagA-positive infected patients compared with CagA-positive infected controls (P = 0.007). CONCLUSION: CagA positive H pylori infection may concur to the development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease. | Cristina Lenzi Alberto Palazzuoli Nicola Giordano Giuliano Alegente Catia Gonnelli Maria Stella Campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura | 2006 | World Journal of Gastroenterology2006，12，48： | 23 |
| 2 | Circumferential mucosal dissection and esophageal perforation in a patient with eosinophilic esophagitis显示文摘A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac in the lower part of the esophagus. Soon after the procedure, the patient suffered from an acute chest pain and subsequent CT scan demonstrated an intramural circumferential dissection of thoracic esophagus, and a mediastinal emphysema. An emergency right thoracotomy was performed, followed by a total esophagectomy with esophagogastroplasty and jejunostomy. The histopathology confirmed that mucosal and submucosal layers were circumferentially detached from muscular wall and showed an eosinophilic infiltration of the whole organ with necrosis and erosions of mucosal, submucosal and muscular layers. The diagnosis was esophageal perforation in eosinophilic esophagitis. | Gennaro Liguori Maurizio Cortale Fabrizio Cimino Michele Sozzi | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 3 | Loss of FHIT function in lung cancer and preinvasive bronchial lesions 显示文摘 | Pastorino U Moiraghi L | 1998 | Cancer Res1998，58，： | 1 |
| 4 | Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities 显示文摘 | SOZZI G TORNIELLI S TAGLIABUE E | 1997 | Cancer Res1997，57，12： | 1 |
| 5 | FHIT in human cancer显示文摘 | Sozzi G Huebner K Croce CM | 1998 | Adv Cancer Res1998，141，： | 1 |
| 6 | The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging显示文摘 | FELD JJ COLLEDGE D SOZZI V | 2007 | Antivir Res2007，76，2： | 1 |
| 7 | Clinical utility of a plasma - based miRNA signature classifier within computed tomography lung cancer screening: A correlative MILD trial study 显示文摘 | Sozzi G Boeri M Rossi M | 2014 | J Clin Oncol2014，32，8： | 1 |
| 8 | Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients, a prospect for early diagrosis显示文摘 | Sozzi G Musso K Ratcliffe C | 1999 | Clin Cancer Res1999，5，10： | 1 |
| 9 | Improved identification of viable myocardium using second harmonic imaging duing dobutamine stress echocardiography显示文摘 | Sozzi F B Poldermabs D Bax J J | 2001 | Heart2001，86，6： | 1 |
| 10 | Abence of FHIT protein in primary lung tumors and cell lines with FHIT gene abnormalities显示文摘 | Sozzi G Tomielli S Tagliabue E ct al | 1997 | Cancer Res1997，57，23： | 1 |
| 11 | Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of hmg cancer patients显示文摘 | Sozzi G Conte D Mariani L | 2001 | Cancer Res2001，61，12： | 1 |
| 12 | Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines显示文摘 | Roz L Gramegna M Ishii H Croce C M Sozzi G | 2002 | Proc Natl Acad Sci USA2002，99，6： | 1 |
| 13 | Replacement of FHIT in cancer cells supresses tumorigenicity显示文摘 | Siprashvili Z Sozzi G Barnes LD | 1997 | Proc Nat Acad USA1997，94，13： | 1 |
| 14 | EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues显示文摘 | Martelli MP Sozzi G Hernandez L | | 0，，2： | 1 |
| 15 | Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients 显示文摘 | Sozzi G Conte D Mariani L | 2001 | Cancer Res2001，61，12： | 1 |
| 16 | Improved identification of viable myocardium using second harmonic imaging duing dobutamine stress echocardiography显示文摘 | Poldermans D Bax J J | 2001 | Heart2001，86，： | 1 |
| 17 | HBV mutants associated with clinical resistance to adefovir dip ivoxil disp lay only small decreases in antiviral sensitivity in vitrol显示文摘 | Locarnini S Shaw T Sozzi T | 2004 | Hepatology2004，40，4： | 1 |
| 18 | Effects of prolonged storage of whole plasma or isolated plasma DNA on the results of irculating DNA quantification assays 显示文摘 | Sozzi G Roz L Conte D | 2005 | J Natl Cancer Inst2005，97，24： | 1 |
| 19 | Replacement of Fhit in cancer cells supresses tumorigenicity显示文摘 | Siprashvili Z Sozzi G Barnes LD | | 0，，： | 1 |
| 20 | Quantification of free circulating DNA as a diagnostic marker in lung cancer 显示文摘 | Sozzi G Conte D Leon M | 2003 | J Clin Oncol2003，21，21： | 1 |
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