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| 1 | The Yin-Yang of osteopontin in nervous system diseases: damage versus repair显示文摘Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic diseases.In fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their survival.The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory response.These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases cleavages.Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions.This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases.Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein. | Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani Annalisa Chiocchetti Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 2 | Extreme Heat Resistance of Food Borne Pathogens Campylobacter jejuni, Escherichia coli , and Salmonella typhimurium on Chicken Breast Fillet during Cooking显示文摘 | Aarieke E.I. de Jong Esther D. van Asselt Marcel H. Zwietering Maarten J. Nauta Rob de Jonge Giuseppe Comi | 2012 | International Journal of Microbiology2012，，： | 1 |
| 3 | Lactic acid bacteria ecology of three traditional fermented sausages produced in the North of Italy as determined by molecular methods显示文摘 | Luca Cocolin Paola Dolci Kalliopi Rantsiou Rosalinda Urso Carlo Cantoni Giuseppe Comi | 2009 | Meat Science2009，，1： | 1 |
| 4 | Mitochondrial DNA restriction enzyme analysis and evaluation of the enological characteristics of Saccharomyces cerevisiae strains isolated from grapes of the wine-producing area of Collio (Italy)显示文摘 | Giuseppe Comi Michela Maifreni Marisa Manzano Corrado Lagazio | 2000 | International Journal of Food Microbiology2000，58，： | 1 |
| 5 | Use of a culture-independent molecular method to study the ecology of Yersinia spp in food显示文摘 | Cocolin L Comi Giuseppe | 2005 | Int J Food Microbiol2005，105，： | 1 |
| 6 | Mitochondrial defect and PGC-1α dysfunction in parkin -associated familial Parkinson’s disease显示文摘 | Consiglia Pacelli Domenico De Rasmo Anna Signorile Ignazio Grattagliano Giuseppe di Tullio Andria D’Orazio Beatrice Nico Giacomo Pietro Comi Dario Ronchi Ermanno Ferranini Domenico Pirolo Peter Seibel Susanna Schubert Antonio Gaballo Gaetano Villani Tizia | 2011 | BBA - Molecular Basis of Disease2011，，8： | 1 |
| 7 | Polymorphic Amplified Typing Sequences and Pulsed-Field Gel Electrophoresis Yield Comparable Results in the Strain Typing of a Diverse Set of Bovine Escherichia coli O157:H7 Isolates显示文摘 | Indira T. Kudva Margaret A. Davis Robert W. Griffin Jeonifer Garren Megan Murray Manohar John Carolyn J. Hovde Stephen B. Calderwood Giuseppe Comi | 2012 | <journal-title>International Journal of Microbiology2012，，： | 1 |
| 8 | Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae显示文摘 | Marilena Marino Carla Bersani Giuseppe Comi | 2001 | International Journal of Food Microbiology2001，，3： | 1 |
| 9 | Characterization of Kloeckera apiculata strains from the Friuli region in Northern Italy 显示文摘 | Giuseppe Comi Patrizia Romano Luca Cocolin | 2001 | Word Journal of Microbiology & Biotechnology2001，17，： | 1 |
| 10 | Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae显示文摘 | Marilena Marino Carla Bersani Giuseppe Comi | 2001 | International Journal of Food Microbiology2001，67，： | 1 |
| 11 | The rpoB gene as a target for PCR-DGGE analysis to follow lactic acid bacterial population dynamics during food fermentations显示文摘 | Kalliopi Rantsiou Giuseppe Comi Luca Cocolin | 2004 | Food Microbiology2004，21，： | 1 |
| 12 | Lactic acid bacteria ecology of three traditional fermented sausages produced in the North of Italy as determined by molecular methods显示文摘 | Luca Cocolin Paola Dolci Kalliopi Rantsiou Rosalinda Urso Carlo Cantoni Giuseppe Comi | 2009 | Meat Science2009，，1： | 1 |
| 13 | Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and Compositae显示文摘 | Marilena Marino Carla Bersani Giuseppe Comi | 2001 | International Journal of Food Microbiology2001，，3： | 1 |
| 14 | Characterisation of naturally fermented sausages produced in the North East of Italy显示文摘 | Giuseppe Comi Rosalinda Urso Lucilla lacumin | 2005 | Meat Science2005，69，3： | 1 |
| 15 | Molecular and technological characterization of Staphylococcus xylosus isolated from naturally fermented Italian sausages by RAPD,Rep-PCR and Sau-PCR analysis显示文摘 | Lucilla Iacumin Giuseppe Comi Carlo Cantoni | 2006 | Meat Science2006，，74： | 1 |
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