共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 老年2型糖尿病肾病患者血清OPN、VEGF、Hcy与肾功能和认知功能障碍的关系分析显示文摘目的:探讨老年2型糖尿病肾病(T2DKD)患者血清骨桥蛋白(OPN)、血管内皮生长因子(VEGF)、同型半胱氨酸(Hcy)与肾功能和认知功能障碍(CD)的关系。方法:选取2017年1月~2022年6月安徽医科大学第二附属医院收治的140例T2DKD患者为T2DKD组,根据是否发生CD分为CD组41例和非CD组99例,选取60例单纯T2DM患者为T2DM组,另选取同期50名体检健康志愿者为对照组。检测血清OPN、VEGF、Hcy和计算肾功能指标[尿白蛋白/肌酐比(UACR)、估计肾小球滤过率(eGFR)]。采用Spearman相关性分析老年T2DKD患者血清OPN、VEGF、Hcy水平与肾功能指标的相关性,采用多因素Logistic回归分析老年T2DKD患者CD的影响因素。结果:对照组、T2DM组、T2DKD组血清OPN、VEGF、Hcy水平和UACR依次升高,eGFR依次降低(P<0.05)。Spearman相关性分析显示,老年T2DKD患者血清OPN、VEGF、Hcy水平与UACR呈正相关,与eGFR呈负相关(P<0.05)。多因素Logistic回归分析显示,稳态模型评估胰岛素抵抗指数(HOMA-IR)、UACR、OPN、VEGF、Hcy升高为老年T2DKD患者CD的独立危险因素,eGFR升高为独立保护因素(P<0.05)。结论:老年T2DKD患者血清OPN、VEGF、Hcy水平升高,与肾功能和CD密切相关,可能成为老年T2DKD患者CD的辅助预测指标。 | 李丹丹 陈晓莉 庞畅 闫奇奇 黎淮 | 2023 | 现代生物医学进展2023，23，16： | 0 |
| 2 | NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases显示文摘Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential therapeutic touchstone and indicative marker for these ailments. This in-depth review brings to light distinct features of NADPH oxidase 4, responsible for generating superoxide and hydrogen peroxide, emphasizing its pivotal role in activating glial cells, inciting inflammation, and disturbing neuronal functions. Significantly, malfunctioning astrocytes, forming the majority in the central nervous system, play a part in advancing neurodegenerative diseases, due to their reactive oxygen species and inflammatory factor secretion. Our study reveals that aiming at NADPH oxidase 4 within astrocytes could be a viable treatment pathway to reduce oxidative damage and halt neurodegenerative processes. Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopontin, offering better prospects for conditions like Alzheimer’s disease and Parkinson’s disease. This review sheds light on the role of NADPH oxidase 4 in neural degeneration, emphasizing its drug target potential, and paving the path for novel treatment approaches to combat these severe conditions. | Napissara Boonpraman Sun Shin Yi | 2024 | Neural Regeneration Research2024，19，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员