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| 1 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 2 | TGFβinhibition during expansion phase increases the chondrogenic re-differentiation capacity of human articular chondrocytes显示文摘 | Narcisi R Signorile L Verhaar JA | | 0，，10： | 1 |
| 3 | C-reactive protein and tumor necrosis factor-alpha in gestational hyperglycemia显示文摘 | Signorile A Bo S Menato G | | 0，，09： | 1 |
| 4 | Obesity or diabetes: what is worse for the mother and for the baby? 显示文摘 | Bo S Menato G Signorile A | 2003 | Diabetes Metab2003，29，21： | 1 |
| 5 | Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis inendometriosis cells显示文摘 | Signorile PG Petraglia F Baldi A | 2014 | J Exp Clin Cancer Res2014，33，1： | 1 |
| 6 | Fatigue induced changes in myoelectric signal characteristics and perceived exertion显示文摘 | Hasson S M Williams J H Signorile J F | 1989 | Can J Sport Sci1989，14，2： | 1 |
| 7 | Fe-Ce-ZSM-5 a new catalyst of outstanding properties in the selective catalytic reduction of NO with NH3 显示文摘 | Carja G Delahay G Signorile C | 2004 | Chemical Com- munications2004，，12： | 1 |
| 8 | Casein phosphopeptides influence calcium uptake by cultured human intestinal HT-29 tumor cells显示文摘 | Ferraretto A Signorile A Gravaghi C | | Journal of Nutrition0，131，： | 1 |
| 9 | Increased muscle strength in paralyzed patients after spinal cord injury:effect of beta-2 adrenergic agonist显示文摘 | Signorile JF Banovac K Gomez M | 1995 | Arch Phys Med Rehabil1995，76，1： | 1 |
| 10 | Clinical effects of a standardized soy extract in postmenopausal women, a pilot study 显示文摘 | Scambia G Mango D Signorile PG | 2000 | Menopause2000，7，2： | 1 |
| 11 | Endometriosis: new concepts in the pathogenesis 显示文摘 | Signorile PG Baldi A | 2010 | The International Journal of Biochemistry and Cell Biology2010，42，6： | 1 |
| 12 | T16189C mitochondrial DNA variant is associated with metabolic syndrome in Caucasian subjects显示文摘 | Palmieri VO Rasmo DD Signorile A | 2011 | Nutrition2011，27，78： | 1 |
| 13 | Simulation and genetic algorithms for ship planning anti shipyard layout 显示文摘 | Bruzzone A Signorile R | 1998 | Simulation1998，71，2： | 1 |
| 14 | Increased muscle strength in paralyzed patients after spinal cord injury: effect of beta-2 adrenergic agonist显示文摘 | Signorile JF Banovac K Gomes M | 1995 | Arch Phys Med Rehabil1995，76，： | 1 |
| 15 | A comparative electro- myographical investigation of muscle utilization patterns using various hand positions during the lat pull-down 显示文摘 | Signorile JF Zink AJ Szwed SP | 2002 | J Strength Cond Res2002，16，4： | 1 |
| 16 | Mitochondrial defect and PGC - la dysfunction in parkin - associated familial Parkinson's disease显示文摘 | Pacelli C De Rasmoa D Signorile A | 2011 | Bioehim Biophys Acta2011，1812，： | 1 |
| 17 | Endocrine dis- ruptors in utero cause ovarian damages linked to endome- triosis 显示文摘 | Signorile PG Spugnini EP Citro G | 2012 | Front Biosei ( Elite Ed)2012，4，： | 1 |
| 18 | cAMP/Ca2+ response element-binding protein plays a central role in the biogenesis of respiratory chain proteins in mammalian cells 显示文摘 | De Rasmo D Signorile A Papa F | 2010 | IUBMB Life2010，62，6： | 1 |
| 19 | Endometriosis : pathogenesis, diagnosis, therapy and association with cancer 显示文摘 | Baldi A Campioni M Signorile PG | 2008 | Oncol Rep2008，19，4： | 1 |
| 20 | Clinical effects of a standardized soyextract in postmenopausal women:a pilot study显示文摘 | Scambia G Mango D Signorile PG | 2000 | Menopause2000，7，2： | 1 |
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